Muhammad Abbas Khan

Mohammad Abdul Hafeez Khan, Twisha Bhattacharyya, Omar Khan et al.

Chronic Kidney Disease (CKD) affects millions of people worldwide, yet its early detection remains challenging, especially in outpatient settings where laboratory-based renal biomarkers are often unavailable. In this work, we investigate the predictive potential of routinely collected non-renal clinical variables for CKD classification, including sociodemographic factors, comorbid conditions, and urinalysis findings. We introduce the Nephrology-Oriented Representation leArning (NORA) approach, which combines supervised contrastive learning with a nonlinear Random Forest classifier. NORA first derives discriminative patient representations from tabular EHR data, which are then used for downstream CKD classification. We evaluated NORA on a clinic-based EHR dataset from Riverside Nephrology Physicians. Our results demonstrated that NORA improves class separability and overall classification performance, particularly enhancing the F1-score for early-stage CKD. Additionally, we assessed the generalizability of NORA on the UCI CKD dataset, demonstrating its effectiveness for CKD risk stratification across distinct patient cohorts.

Mohammad Abdul Hafeez Khan, Marcello Mattei Di Eugeni, Benjamin Diaz et al.

Accurate assessment of intraventricular blood flow is essential for evaluating hemodynamic conditions in patients supported by Left Ventricular Assist Devices (LVADs). However, clinical imaging is either incompatible with LVADs or yields sparse, low-quality velocity data. While Computational Fluid Dynamics (CFD) simulations provide high-fidelity data, they are computationally intensive and impractical for routine clinical use. To address this, we propose LVADNet3D, a 3D convolutional autoencoder that reconstructs full-resolution intraventricular velocity fields from sparse velocity vector inputs. In contrast to a standard UNet3D model, LVADNet3D incorporates hybrid downsampling and a deeper encoder-decoder architecture with increased channel capacity to better capture spatial flow patterns. To train and evaluate the models, we generate a high-resolution synthetic dataset of intraventricular blood flow in LVAD-supported hearts using CFD simulations. We also investigate the effect of conditioning the models on anatomical and physiological priors. Across various input configurations, LVADNet3D outperforms the baseline UNet3D model, yielding lower reconstruction error and higher PSNR results.