Wanting Yu

Bowen Li, Dar-In Tai, Ke Yan et al.

Background & Aims: Hepatic steatosis is a major cause of chronic liver disease. 2D ultrasound is the most widely used non-invasive tool for screening and monitoring, but associated diagnoses are highly subjective. We developed a scalable deep learning (DL) algorithm for quantitative scoring of liver steatosis from 2D ultrasound images. Approach & Results: Using retrospectively collected multi-view ultrasound data from 3,310 patients, 19,513 studies, and 228,075 images, we trained a DL algorithm to diagnose steatosis stages (healthy, mild, moderate, or severe) from ultrasound diagnoses. Performance was validated on two multi-scanner unblinded and blinded (initially to DL developer) histology-proven cohorts (147 and 112 patients) with histopathology fatty cell percentage diagnoses, and a subset with FibroScan diagnoses. We also quantified reliability across scanners and viewpoints. Results were evaluated using Bland-Altman and receiver operating characteristic (ROC) analysis. The DL algorithm demonstrates repeatable measurements with a moderate number of images (3 for each viewpoint) and high agreement across 3 premium ultrasound scanners. High diagnostic performance was observed across all viewpoints: area under the curves of the ROC to classify >=mild, >=moderate, =severe steatosis grades were 0.85, 0.90, and 0.93, respectively. The DL algorithm outperformed or performed at least comparably to FibroScan with statistically significant improvements for all levels on the unblinded histology-proven cohort, and for =severe steatosis on the blinded histology-proven cohort. Conclusions: The DL algorithm provides a reliable quantitative steatosis assessment across view and scanners on two multi-scanner cohorts. Diagnostic performance was high with comparable or better performance than FibroScan.

Wanting Yu, Hongyi Yu, Lingyun Jiang et al.

Adversarial examples reveal the vulnerability and unexplained nature of neural networks. Studying the defense of adversarial examples is of considerable practical importance. Most adversarial examples that misclassify networks are often undetectable by humans. In this paper, we propose a defense model to train the classifier into a human-perception classification model with shape preference. The proposed model comprising a texture transfer network (TTN) and an auxiliary defense generative adversarial networks (GAN) is called Human-perception Auxiliary Defense GAN (HAD-GAN). The TTN is used to extend the texture samples of a clean image and helps classifiers focus on its shape. GAN is utilized to form a training framework for the model and generate the necessary images. A series of experiments conducted on MNIST, Fashion-MNIST and CIFAR10 show that the proposed model outperforms the state-of-the-art defense methods for network robustness. The model also demonstrates a significant improvement on defense capability of adversarial examples.