Sepehr Asgarian

Arman Aghaee, Sepehr Asgarian, Jouhyun Jeon

Simulating high-fidelity patients offers a powerful avenue for studying complex diseases while addressing the challenges of fragmented, biased, and privacy-restricted real-world data. In this study, we introduce SynthAgent, a novel Multi-Agent System (MAS) framework designed to model obesity patients with comorbid mental disorders, including depression, anxiety, social phobia, and binge eating disorder. SynthAgent integrates clinical and medical evidence from claims data, population surveys, and patient-centered literature to construct personalized virtual patients enriched with personality traits that influence adherence, emotion regulation, and lifestyle behaviors. Through autonomous agent interactions, the system simulates disease progression, treatment response, and life management across diverse psychosocial contexts. Evaluation of more than 100 generated patients demonstrated that GPT-5 and Claude 4.5 Sonnet achieved the highest fidelity as the core engine in the proposed MAS framework, outperforming Gemini 2.5 Pro and DeepSeek-R1. SynthAgent thus provides a scalable and privacy-preserving framework for exploring patient journeys, behavioral dynamics, and decision-making processes in both medical and psychological domains.

Sepehr Asgarian, Qayam Jetha, Jouhyun Jeon

In the competitive landscape of advertising, success hinges on effectively navigating and leveraging complex interactions among consumers, advertisers, and advertisement platforms. These multifaceted interactions compel advertisers to optimize strategies for modeling consumer behavior, enhancing brand recall, and tailoring advertisement content. To address these challenges, we present MindMem, a multimodal predictive model for advertisement memorability. By integrating textual, visual, and auditory data, MindMem achieves state-of-the-art performance, with a Spearman's correlation coefficient of 0.631 on the LAMBDA and 0.731 on the Memento10K dataset, consistently surpassing existing methods. Furthermore, our analysis identified key factors influencing advertisement memorability, such as video pacing, scene complexity, and emotional resonance. Expanding on this, we introduced MindMem-ReAd (MindMem-Driven Re-generated Advertisement), which employs Large Language Model-based simulations to optimize advertisement content and placement, resulting in up to a 74.12% improvement in advertisement memorability. Our results highlight the transformative potential of Artificial Intelligence in advertising, offering advertisers a robust tool to drive engagement, enhance competitiveness, and maximize impact in a rapidly evolving market.