Lukas Fischer

Mohit Kumar, Bernhard A. Moser, Lukas Fischer

Privacy-utility tradeoff remains as one of the fundamental issues of differentially private machine learning. This paper introduces a geometrically inspired kernel-based approach to mitigate the accuracy-loss issue in classification. In this approach, a representation of the affine hull of given data points is learned in Reproducing Kernel Hilbert Spaces (RKHS). This leads to a novel distance measure that hides privacy-sensitive information about individual data points and improves the privacy-utility tradeoff via significantly reducing the risk of membership inference attacks. The effectiveness of the approach is demonstrated through experiments on MNIST dataset, Freiburg groceries dataset, and a real biomedical dataset. It is verified that the approach remains computationally practical. The application of the approach to federated learning is considered and it is observed that the accuracy-loss due to data being distributed is either marginal or not significantly high.

Mohit Kumar, Weiping Zhang, Lukas Fischer et al.

This study leverages the data representation capability of fuzzy based membership-mappings for practical secure distributed deep learning using fully homomorphic encryption. The impracticality issue of secure machine (deep) learning with fully homomorphic encrypted data, arising from large computational overhead, is addressed via applying fuzzy attributes. Fuzzy attributes are induced by globally convergent and robust variational membership-mappings based local deep models. Fuzzy attributes combine the local deep models in a robust and flexible manner such that the global model can be evaluated homomorphically in an efficient manner using a boolean circuit composed of bootstrapped binary gates. The proposed method, while preserving privacy in a distributed learning scenario, remains accurate, practical, and scalable. The method is evaluated through numerous experiments including demonstrations through MNIST dataset and Freiburg Groceries Dataset. Further, a biomedical application related to mental stress detection on individuals is considered.

Yingqiang Gao, Lukas Fischer, Alexa Lintner et al.

Audio descriptions (ADs) function as acoustic commentaries designed to assist blind persons and persons with visual impairments in accessing digital media content on television and in movies, among other settings. As an accessibility service typically provided by trained AD professionals, the generation of ADs demands significant human effort, making the process both time-consuming and costly. Recent advancements in natural language processing (NLP) and computer vision (CV), particularly in large language models (LLMs) and vision-language models (VLMs), have allowed for getting a step closer to automatic AD generation. This paper reviews the technologies pertinent to AD generation in the era of LLMs and VLMs: we discuss how state-of-the-art NLP and CV technologies can be applied to generate ADs and identify essential research directions for the future.

Maria Korobeynikova, Alessia Battisti, Lukas Fischer et al.

Current evaluation of German automatic text simplification (ATS) relies on general-purpose metrics such as SARI, BLEU, and BERTScore, which insufficiently capture simplification quality in terms of simplicity, meaning preservation, and fluency. While specialized metrics like LENS have been developed for English, corresponding efforts for German have lagged behind due to the absence of human-annotated corpora. To close this gap, we introduce DETECT, the first German-specific metric that holistically evaluates ATS quality across all three dimensions of simplicity, meaning preservation, and fluency, and is trained entirely on synthetic large language model (LLM) responses. Our approach adapts the LENS framework to German and extends it with (i) a pipeline for generating synthetic quality scores via LLMs, enabling dataset creation without human annotation, and (ii) an LLM-based refinement step for aligning grading criteria with simplification requirements. To the best of our knowledge, we also construct the largest German human evaluation dataset for text simplification to validate our metric directly. Experimental results show that DETECT achieves substantially higher correlations with human judgments than widely used ATS metrics, with particularly strong gains in meaning preservation and fluency. Beyond ATS, our findings highlight both the potential and the limitations of LLMs for automatic evaluation and provide transferable guidelines for general language accessibility tasks.

Lukas Fischer, Yingqiang Gao, Alexa Lintner et al.

Audio description (AD) is a crucial accessibility service provided to blind persons and persons with visual impairment, designed to convey visual information in acoustic form. Despite recent advancements in multilingual machine translation research, the lack of well-crafted and time-synchronized AD data impedes the development of audio description translation (ADT) systems that address the needs of multilingual countries such as Switzerland. Furthermore, since the majority of ADT systems rely solely on text, uncertainty exists as to whether incorporating visual information from the corresponding video clips can enhance the quality of ADT outputs. In this work, we present SwissADT, the first ADT system implemented for three main Swiss languages and English. By collecting well-crafted AD data augmented with video clips in German, French, Italian, and English, and leveraging the power of Large Language Models (LLMs), we aim to enhance information accessibility for diverse language populations in Switzerland by automatically translating AD scripts to the desired Swiss language. Our extensive experimental ADT results, composed of both automatic and human evaluations of ADT quality, demonstrate the promising capability of SwissADT for the ADT task. We believe that combining human expertise with the generation power of LLMs can further enhance the performance of ADT systems, ultimately benefiting a larger multilingual target population.

Mohit Kumar, Bernhard A. Moser, Lukas Fischer et al.

In order to develop machine learning and deep learning models that take into account the guidelines and principles of trustworthy AI, a novel information theoretic trustworthy AI framework is introduced. A unified approach to "privacy-preserving interpretable and transferable learning" is considered for studying and optimizing the tradeoffs between privacy, interpretability, and transferability aspects. A variational membership-mapping Bayesian model is used for the analytical approximations of the defined information theoretic measures for privacy-leakage, interpretability, and transferability. The approach consists of approximating the information theoretic measures via maximizing a lower-bound using variational optimization. The study presents a unified information theoretic approach to study different aspects of trustworthy AI in a rigorous analytical manner. The approach is demonstrated through numerous experiments on benchmark datasets and a real-world biomedical application concerned with the detection of mental stress on individuals using heart rate variability analysis.

Mohit Kumar, Bernhard A. Moser, Lukas Fischer et al.

A fuzzy theoretic analytical approach was recently introduced that leads to efficient and robust models while addressing automatically the typical issues associated to parametric deep models. However, a formal conceptualization of the fuzzy theoretic analytical deep models is still not available. This paper introduces using measure theoretic basis the notion of \emph{membership-mapping} for representing data points through attribute values (motivated by fuzzy theory). A property of the membership-mapping, that can be exploited for data representation learning, is of providing an interpolation on the given data points in the data space. An analytical approach to the variational learning of a membership-mappings based data representation model is considered.

Lukas Fischer, Samuel Läubli

Machine translation (MT) has been shown to produce a number of errors that require human post-editing, but the extent to which professional human translation (HT) contains such errors has not yet been compared to MT. We compile pre-translated documents in which MT and HT are interleaved, and ask professional translators to flag errors and post-edit these documents in a blind evaluation. We find that the post-editing effort for MT segments is only higher in two out of three language pairs, and that the number of segments with wrong terminology, omissions, and typographical problems is similar in HT.

Florian Kromp, Lukas Fischer, Eva Bozsaky et al.

Separating and labeling each instance of a nucleus (instance-aware segmentation) is the key challenge in segmenting single cell nuclei on fluorescence microscopy images. Deep Neural Networks can learn the implicit transformation of a nuclear image into a probability map indicating the class membership of each pixel (nucleus or background), but the use of post-processing steps to turn the probability map into a labeled object mask is error-prone. This especially accounts for nuclear images of tissue sections and nuclear images across varying tissue preparations. In this work, we aim to evaluate the performance of state-of-the-art deep learning architectures to segment nuclei in fluorescence images of various tissue origins and sample preparation types without post-processing. We compare architectures that operate on pixel to pixel translation and an architecture that operates on object detection and subsequent locally applied segmentation. In addition, we propose a novel strategy to create artificial images to extend the training set. We evaluate the influence of ground truth annotation quality, image scale and segmentation complexity on segmentation performance. Results show that three out of four deep learning architectures (U-Net, U-Net with ResNet34 backbone, Mask R-CNN) can segment fluorescent nuclear images on most of the sample preparation types and tissue origins with satisfactory segmentation performance. Mask R-CNN, an architecture designed to address instance aware segmentation tasks, outperforms other architectures. Equal nuclear mean size, consistent nuclear annotations and the use of artificially generated images result in overall acceptable precision and recall across different tissues and sample preparation types.

Hamid Eghbal-zadeh, Lukas Fischer, Thomas Hoch

The recent success of Generative Adversarial Networks (GAN) is a result of their ability to generate high quality images from a latent vector space. An important application is the generation of images from a text description, where the text description is encoded and further used in the conditioning of the generated image. Thus the generative network has to additionally learn a mapping from the text latent vector space to a highly complex and multi-modal image data distribution, which makes the training of such models challenging. To handle the complexities of fashion image and meta data, we propose Ontology Generative Adversarial Networks (O-GANs) for fashion image synthesis that is conditioned on an hierarchical fashion ontology in order to improve the image generation fidelity. We show that the incorporation of the ontology leads to better image quality as measured by Fréchet Inception Distance and Inception Score. Additionally, we show that the O-GAN achieves better conditioning results evaluated by implicit similarity between the text and the generated image.

Hamid Eghbal-zadeh, Lukas Fischer, Niko Popitsch et al.

Diagnosis and risk stratification of cancer and many other diseases require the detection of genomic breakpoints as a prerequisite of calling copy number alterations (CNA). This, however, is still challenging and requires time-consuming manual curation. As deep-learning methods outperformed classical state-of-the-art algorithms in various domains and have also been successfully applied to life science problems including medicine and biology, we here propose Deep SNP, a novel Deep Neural Network to learn from genomic data. Specifically, we used a manually curated dataset from 12 genomic single nucleotide polymorphism array (SNPa) profiles as truth-set and aimed at predicting the presence or absence of genomic breakpoints, an indicator of structural chromosomal variations, in windows of 40,000 probes. We compare our results with well-known neural network models as well as Rawcopy though this tool is designed to predict breakpoints and in addition genomic segments with high sensitivity. We show, that Deep SNP is capable of successfully predicting the presence or absence of a breakpoint in large genomic windows and outperforms state-of-the-art neural network models. Qualitative examples suggest that integration of a localization unit may enable breakpoint detection and prediction of genomic segments, even if the breakpoint coordinates were not provided for network training. These results warrant further evaluation of DeepSNP for breakpoint localization and subsequent calling of genomic segments.