Po Yang

Xulong Wang, Yu Zhang, Menghui Zhou et al.

Identifying and utilising various biomarkers for tracking Alzheimer's disease (AD) progression have received many recent attentions and enable helping clinicians make the prompt decisions. Traditional progression models focus on extracting morphological biomarkers in regions of interest (ROIs) from MRI/PET images, such as regional average cortical thickness and regional volume. They are effective but ignore the relationships between brain ROIs over time, which would lead to synergistic deterioration. For exploring the synergistic deteriorating relationship between these biomarkers, in this paper, we propose a novel spatio-temporal similarity measure based multi-task learning approach for effectively predicting AD progression and sensitively capturing the critical relationships between biomarkers. Specifically, we firstly define a temporal measure for estimating the magnitude and velocity of biomarker change over time, which indicate a changing trend(temporal). Converting this trend into the vector, we then compare this variability between biomarkers in a unified vector space(spatial). The experimental results show that compared with directly ROI based learning, our proposed method is more effective in predicting disease progression. Our method also enables performing longitudinal stability selection to identify the changing relationships between biomarkers, which play a key role in disease progression. We prove that the synergistic deteriorating biomarkers between cortical volumes or surface areas have a significant effect on the cognitive prediction.

Ruoling Peng, Kang Liu, Po Yang et al.

Pest identification is a crucial aspect of pest control in agriculture. However, most farmers are not capable of accurately identifying pests in the field, and there is a limited number of structured data sources available for rapid querying. In this work, we explored using domain-agnostic general pre-trained large language model(LLM) to extract structured data from agricultural documents with minimal or no human intervention. We propose a methodology that involves text retrieval and filtering using embedding-based retrieval, followed by LLM question-answering to automatically extract entities and attributes from the documents, and transform them into structured data. In comparison to existing methods, our approach achieves consistently better accuracy in the benchmark while maintaining efficiency.

Zhipeng Yuan, Yu Zhang, Gaoshan Bi et al.

Wheat yellow rust, caused by the fungus Puccinia striiformis, is a critical disease affecting wheat crops across Britain, leading to significant yield losses and economic consequences. Given the rapid environmental changes and the evolving virulence of pathogens, there is a growing need for innovative approaches to predict and manage such diseases over the long term. This study explores the feasibility of using deep learning models to predict outbreaks of wheat yellow rust in British fields, offering a proactive approach to disease management. We construct a yellow rust dataset with historial weather information and disease indicator acrossing multiple regions in England. We employ two poweful deep learning models, including fully connected neural networks and long short-term memory to develop predictive models capable of recognizing patterns and predicting future disease outbreaks.The models are trained and validated in a randomly sliced datasets. The performance of these models with different predictive time steps are evaluated based on their accuracy, precision, recall, and F1-score. Preliminary results indicate that deep learning models can effectively capture the complex interactions between multiple factors influencing disease dynamics, demonstrating a promising capacity to forecast wheat yellow rust with considerable accuracy. Specifically, the fully-connected neural network achieved 83.65% accuracy in a disease prediction task with 6 month predictive time step setup. These findings highlight the potential of deep learning to transform disease management strategies, enabling earlier and more precise interventions. Our study provides a methodological framework for employing deep learning in agricultural settings but also opens avenues for future research to enhance the robustness and applicability of predictive models in combating crop diseases globally.

Po Yang, Jun Qi, Xulong Wang et al.

Recent outbreak of COVID-19 has led a rapid global spread around the world. Many countries have implemented timely intensive suppression to minimize the infections, but resulted in high case fatality rate (CFR) due to critical demand of health resources. Other country-based factors such as sociocultural issues, ageing population etc., has also influenced practical effectiveness of taking interventions to improve morality in early phase. To better understand the relationship of these factors across different countries with COVID-19 CFR is of primary importance to prepare for potentially second wave of COVID-19 infections. In the paper, we propose a novel regularized multi-task learning based factor analysis approach for quantifying country-based factors affecting CFR in early phase of COVID-19 epidemic. We formulate the prediction of CFR progression as a ML regression problem with observed CFR and other countries-based factors. In this formulation, all CFR related factors were categorized into 6 sectors with 27 indicators. We proposed a hybrid feature selection method combining filter, wrapper and tree-based models to calibrate initial factors for a preliminary feature interaction. Then we adopted two typical single task model (Ridge and Lasso regression) and one state-of-the-art MTFL method (fused sparse group lasso) in our formulation. The fused sparse group Lasso (FSGL) method allows the simultaneous selection of a common set of country-based factors for multiple time points of COVID-19 epidemic and also enables incorporating temporal smoothness of each factor over the whole early phase period. Finally, we proposed one novel temporal voting feature selection scheme to balance the weight instability of multiple factors in our MTFL model.