Lenny A. Romero

Juan S. Sierra, Jesus Pineda, Daniela Rueda et al.

Specular microscopy assessment of the human corneal endothelium (CE) in Fuchs' dystrophy is challenging due to the presence of dark image regions called guttae. This paper proposes a UNet-based segmentation approach that requires minimal post-processing and achieves reliable CE morphometric assessment and guttae identification across all degrees of Fuchs' dystrophy. We cast the segmentation problem as a regression task of the cell and gutta signed distance maps instead of a pixel-level classification task as typically done with UNets. Compared to the conventional UNet classification approach, the distance-map regression approach converges faster in clinically relevant parameters. It also produces morphometric parameters that agree with the manually-segmented ground-truth data, namely the average cell density difference of -41.9 cells/mm2 (95% confidence interval (CI) [-306.2, 222.5]) and the average difference of mean cell area of 14.8 um2 (95% CI [-41.9, 71.5]). These results suggest a promising alternative for CE assessment.

Jhacson Meza, Sonia H. Contreras-Ortiz, Lenny A. Romero et al.

We propose a three-dimensional (3D) multimodal medical imaging system that combines freehand ultrasound and structured light 3D reconstruction in a single coordinate system without requiring registration. To the best of our knowledge, these techniques have not been combined before as a multimodal imaging technique. The system complements the internal 3D information acquired with ultrasound, with the external surface measured with the structure light technique. Moreover, the ultrasound probe's optical tracking for pose estimation was implemented based on a convolutional neural network. Experimental results show the system's high accuracy and reproducibility, as well as its potential for preoperative and intraoperative applications. The experimental multimodal error, or the distance from two surfaces obtained with different modalities, was 0.12 mm. The code is available as a Github repository.

Jhacson Meza, Lenny A. Romero, Andres G. Marrugo

Despite the attention marker-less pose estimation has attracted in recent years, marker-based approaches still provide unbeatable accuracy under controlled environmental conditions. Thus, they are used in many fields such as robotics or biomedical applications but are primarily implemented through classical approaches, which require lots of heuristics and parameter tuning for reliable performance under different environments. In this work, we propose MarkerPose, a robust, real-time pose estimation system based on a planar target of three circles and a stereo vision system. MarkerPose is meant for high-accuracy pose estimation applications. Our method consists of two deep neural networks for marker point detection. A SuperPoint-like network for pixel-level accuracy keypoint localization and classification, and we introduce EllipSegNet, a lightweight ellipse segmentation network for sub-pixel-level accuracy keypoint detection. The marker's pose is estimated through stereo triangulation. The target point detection is robust to low lighting and motion blur conditions. We compared MarkerPose with a detection method based on classical computer vision techniques using a robotic arm for validation. The results show our method provides better accuracy than the classical technique. Finally, we demonstrate the suitability of MarkerPose in a 3D freehand ultrasound system, which is an application where highly accurate pose estimation is required. Code is available in Python and C++ at https://github.com/jhacsonmeza/MarkerPose.

Raúl Vargas, Lenny A. Romero, Song Zhang et al.

This Letter presents a novel structured light system model that effectively considers local lens distortion by pixel-wise rational functions. We leverage the stereo method for initial calibration and then estimate the rational model for each pixel. Our proposed model can achieve high measurement accuracy within and outside the calibration volume, demonstrating its robustness and accuracy.