Yun Kwok Wing

Xinxin Lin, Guangxin Dai, Yi Zhong et al.

Large language models (LLMs) hold transformative potential for medical decision support yet their application in psychiatry remains constrained by hallucinations and superficial reasoning. This limitation is particularly acute in light-parameter LLMs which are essential for privacy-preserving and efficient clinical deployment. Existing training paradigms prioritize linguistic fluency over structured clinical logic and result in a fundamental misalignment with professional diagnostic cognition. Here we introduce ClinMPO, a reinforcement learning framework designed to align the internal reasoning of LLMs with professional psychiatric practice. The framework employs a specialized reward model trained independently on a dataset derived from 4,474 psychiatry journal articles and structured according to evidence-based medicine principles. We evaluated ClinMPO on a unseen subset of the benchmark designed to isolate reasoning capabilities from rote memorization. This test set comprises items where leading large-parameter LLMs consistently fail. We compared the ClinMPO-aligned light LLM performance against a cohort of 300 medical students. The ClinMPO-tuned Qwen3-8B model achieved a diagnostic accuracy of 31.4% and surpassed the human benchmark of 30.8% on these complex cases. These results demonstrate that medical evidence-guided optimization enables light-parameter LLMs to master complex reasoning tasks. Our findings suggest that explicit cognitive alignment offers a scalable pathway to reliable and safe psychiatric decision support.

Yujie Nie, Jianzhang Ni, Yonglong Ye et al.

Accurate diagnosis of Alzheimer's disease (AD) is essential for enabling timely intervention and slowing disease progression. Multimodal diagnostic approaches offer considerable promise by integrating complementary information across behavioral and perceptual domains. Eye-tracking and facial features, in particular, are important indicators of cognitive function, reflecting attentional distribution and neurocognitive state. However, few studies have explored their joint integration for auxiliary AD diagnosis. In this study, we propose a multimodal cross-enhanced fusion framework that synergistically leverages eye-tracking and facial features for AD detection. The framework incorporates two key modules: (a) a Cross-Enhanced Fusion Attention Module (CEFAM), which models inter-modal interactions through cross-attention and global enhancement, and (b) a Direction-Aware Convolution Module (DACM), which captures fine-grained directional facial features via horizontal-vertical receptive fields. Together, these modules enable adaptive and discriminative multimodal representation learning. To support this work, we constructed a synchronized multimodal dataset, including 25 patients with AD and 25 healthy controls (HC), by recording aligned facial video and eye-tracking sequences during a visual memory-search paradigm, providing an ecologically valid resource for evaluating integration strategies. Extensive experiments on this dataset demonstrate that our framework outperforms traditional late fusion and feature concatenation methods, achieving a classification accuracy of 95.11% in distinguishing AD from HC, highlighting superior robustness and diagnostic performance by explicitly modeling inter-modal dependencies and modality-specific contributions.

Zhi Zhang, Yan Liu, Mengxia Gao et al.

Psychological resilience, defined as the ability to rebound from adversity, is crucial for mental health. Compared with traditional resilience assessments through self-reported questionnaires, resilience assessments based on neurological data offer more objective results with biological markers, hence significantly enhancing credibility. This paper proposes a novel data-efficient model to address the scarcity of neurological data. We employ Neuro Kolmogorov-Arnold Networks as the structure of the prediction model. In the training stage, a new trait-informed multimodal representation algorithm with a smart chunk technique is proposed to learn the shared latent space with limited data. In the test stage, a new noise-informed inference algorithm is proposed to address the low signal-to-noise ratio of the neurological data. The proposed model not only shows impressive performance on both public datasets and self-constructed datasets but also provides some valuable psychological hypotheses for future research.