Giulio Anichini

Alistair Weld, Luke Dixon, Giulio Anichini et al.

Purpose: Intraoperative ultrasound scanning is a demanding visuotactile task. It requires operators to simultaneously localise the ultrasound perspective and manually perform slight adjustments to the pose of the probe, making sure not to apply excessive force or breaking contact with the tissue, whilst also characterising the visible tissue. Method: To analyse the probe-tissue contact, an iterative filtering and topological method is proposed to identify the underlying visible tissue, which can be used to detect acoustic shadow and construct confidence maps of perceptual salience. Results: For evaluation, datasets containing both in vivo and medical phantom data are created. A suite of evaluations is performed, including an evaluation of acoustic shadow classification. Compared to an ablation, deep learning, and statistical method, the proposed approach achieves superior classification on in vivo data, achieving an F_beta score of 0.864, in comparison to 0.838, 0.808, 0.808. A novel framework for evaluating the confidence estimation of probe tissue contact is created. The phantom data is captured specifically for this, and comparison is made against two established methods. The proposed method produced the superior response, achieving an average normalised root mean square error of 0.168, in comparison to 1.836 and 4.542. Evaluation is also extended to determine the algorithm's robustness to parameter perturbation, speckle noise, data distribution shift, and capability for guiding a robotic scan. Conclusion: The results of this comprehensive set of experiments justify the potential clinical value of the proposed algorithm, which can be used to support clinical training and robotic ultrasound automation.

Alistair Weld, Michael Dyck, Julian Klodmann et al.

The aim of this paper is to introduce a robotic platform for autonomous iUS tissue scanning to optimise intraoperative diagnosis and improve surgical resection during robot-assisted operations. To guide anatomy specific robotic scanning and generate a representation of the robot task space, fast and accurate techniques for the recovery of 3D morphological structures of the surgical cavity are developed. The prototypic DLR MIRO surgical robotic arm is used to control the applied force and the in-plane motion of the US transducer. A key application of the proposed platform is the scanning of brain tissue to guide tumour resection.

Tobias Czempiel, Alfie Roddan, Maria Leiloglou et al.

This study investigates the reconstruction of hyperspectral signatures from RGB data to enhance surgical imaging, utilizing the publicly available HeiPorSPECTRAL dataset from porcine surgery and an in-house neurosurgery dataset. Various architectures based on convolutional neural networks (CNNs) and transformer models are evaluated using comprehensive metrics. Transformer models exhibit superior performance in terms of RMSE, SAM, PSNR and SSIM by effectively integrating spatial information to predict accurate spectral profiles, encompassing both visible and extended spectral ranges. Qualitative assessments demonstrate the capability to predict spectral profiles critical for informed surgical decision-making during procedures. Challenges associated with capturing both the visible and extended hyperspectral ranges are highlighted using the MAE, emphasizing the complexities involved. The findings open up the new research direction of hyperspectral reconstruction for surgical applications and clinical use cases in real-time surgical environments.

Alistair Weld, Luke Dixon, Alfie Roddan et al.

Purpose: An investigation of the challenge of annotating discrete segmentations of brain tumours in ultrasound, with a focus on the issue of aleatoric uncertainty along the tumour margin, particularly for diffuse tumours. A segmentation protocol and method is proposed that incorporates this margin-related uncertainty while minimising the interobserver variance through reduced subjectivity, thereby diminishing annotator epistemic uncertainty. Approach: A sparse confidence method for annotation is proposed, based on a protocol designed using computer vision and radiology theory. Results: Output annotations using the proposed method are compared with the corresponding professional discrete annotation variance between the observers. A linear relationship was measured within the tumour margin region, with a Pearson correlation of 0.8. The downstream application was explored, comparing training using confidence annotations as soft labels with using the best discrete annotations as hard labels. In all evaluation folds, the Brier score was superior for the soft-label trained network. Conclusion: A formal framework was constructed to demonstrate the infeasibility of discrete annotation of brain tumours in B-mode ultrasound. Subsequently, a method for sparse confidence-based annotation is proposed and evaluated. Keywords: Brain tumours, ultrasound, confidence, annotation.