M. Murugappan

Alvee Hassan, Rusab Sarmun, Muhammad E. H. Chowdhury et al.

Early detection of coronary artery disease (CAD) is critical for reducing mortality and improving patient treatment planning. While angiographic image analysis from X-rays is a common and cost-effective method for identifying cardiac abnormalities, including stenotic coronary arteries, poor image quality can significantly impede clinical diagnosis. We present the Coronary Artery Segmentation and Refinement Network (CASR-Net), a three-stage pipeline comprising image preprocessing, segmentation, and refinement. A novel multichannel preprocessing strategy combining CLAHE and an improved Ben Graham method provides incremental gains, increasing Dice Score Coefficient (DSC) by 0.31-0.89% and Intersection over Union (IoU) by 0.40-1.16% compared with using the techniques individually. The core innovation is a segmentation network built on a UNet with a DenseNet121 encoder and a Self-organized Operational Neural Network (Self-ONN) based decoder, which preserves the continuity of narrow and stenotic vessel branches. A final contour refinement module further suppresses false positives. Evaluated with 5-fold cross-validation on a combination of two public datasets that contain both healthy and stenotic arteries, CASR-Net outperformed several state-of-the-art models, achieving an IoU of 61.43%, a DSC of 76.10%, and clDice of 79.36%. These results highlight a robust approach to automated coronary artery segmentation, offering a valuable tool to support clinicians in diagnosis and treatment planning.

Andrei Velichko, Maksim Belyaev, Yuriy Izotov et al.

Entropy measures are effective features for time series classification problems. Traditional entropy measures, such as Shannon entropy, use probability distribution function. However, for the effective separation of time series, new entropy estimation methods are required to characterize the chaotic dynamic of the system. Our concept of Neural Network Entropy (NNetEn) is based on the classification of special datasets in relation to the entropy of the time series recorded in the reservoir of the neural network. NNetEn estimates the chaotic dynamics of time series in an original way and does not take into account probability distribution functions. We propose two new classification metrics: R2 Efficiency and Pearson Efficiency. The efficiency of NNetEn is verified on separation of two chaotic time series of sine mapping using dispersion analysis. For two close dynamic time series (r = 1.1918 and r = 1.2243), the F-ratio has reached the value of 124 and reflects high efficiency of the introduced method in classification problems. The electroenceph-alography signal classification for healthy persons and patients with Alzheimer disease illustrates the practical application of the NNetEn features. Our computations demonstrate the synergistic effect of increasing classification accuracy when applying traditional entropy measures and the NNetEn concept conjointly. An implementation of the algorithms in Python is presented.

Maksim Belyaev, Murugappan Murugappan, Andrei Velichko et al.

The study presents the concept of a computationally efficient machine learning (ML) model for diagnosing and monitoring Parkinson's disease (PD) in an Internet of Things (IoT) environment using rest-state EEG signals (rs-EEG). We computed different types of entropy from EEG signals and found that Fuzzy Entropy performed the best in diagnosing and monitoring PD using rs-EEG. We also investigated different combinations of signal frequency ranges and EEG channels to accurately diagnose PD. Finally, with a fewer number of features (11 features), we achieved a maximum classification accuracy (ARKF) of ~99.9%. The most prominent frequency range of EEG signals has been identified, and we have found that high classification accuracy depends on low-frequency signal components (0-4 Hz). Moreover, the most informative signals were mainly received from the right hemisphere of the head (F8, P8, T8, FC6). Furthermore, we assessed the accuracy of the diagnosis of PD using three different lengths of EEG data (150-1000 samples). Because the computational complexity is reduced by reducing the input data. As a result, we have achieved a maximum mean accuracy of 99.9% for a sample length (LEEG) of 1000 (~7.8 seconds), 98.2% with a LEEG of 800 (~6.2 seconds), and 79.3% for LEEG = 150 (~1.2 seconds). By reducing the number of features and segment lengths, the computational cost of classification can be reduced. Lower-performance smart ML sensors can be used in IoT environments for enhances human resilience to PD.

Md. Shaheenur Islam Sumon, Md. Sakib Bin Islam, Md. Sohanur Rahman et al.

The early detection and prediction of cardiovascular diseases are crucial for reducing the severe morbidity and mortality associated with these conditions worldwide. A multi-headed self-attention mechanism, widely used in natural language processing (NLP), is operated by Transformers to understand feature interactions in feature spaces. However, the relationships between various features within biological systems remain ambiguous in these spaces, highlighting the necessity of early detection and prediction of cardiovascular diseases to reduce the severe morbidity and mortality with these conditions worldwide. We handle this issue with CardioTabNet, which exploits the strength of tab transformer to extract feature space which carries strong understanding of clinical cardiovascular data and its feature ranking. As a result, performance of downstream classical models significantly showed outstanding result. Our study utilizes the open-source dataset for heart disease prediction with 1190 instances and 11 features. In total, 11 features are divided into numerical (age, resting blood pressure, cholesterol, maximum heart rate, old peak, weight, and fasting blood sugar) and categorical (resting ECG, exercise angina, and ST slope). Tab transformer was used to extract important features and ranked them using random forest (RF) feature ranking algorithm. Ten machine-learning models were used to predict heart disease using selected features. After extracting high-quality features, the top downstream model (a hyper-tuned ExtraTree classifier) achieved an average accuracy rate of 94.1% and an average Area Under Curve (AUC) of 95.0%. Furthermore, a nomogram analysis was conducted to evaluate the model's effectiveness in cardiovascular risk assessment. A benchmarking study was conducted using state-of-the-art models to evaluate our transformer-driven framework.

Ravikiran Parameshwara, Soujanya Narayana, Murugappan Murugappan et al.

While Parkinson's disease (PD) is typically characterized by motor disorder, there is evidence of diminished emotion perception in PD patients. This study examines the utility of affective Electroencephalography (EEG) signals to understand emotional differences between PD vs Healthy Controls (HC), and for automated PD detection. Employing traditional machine learning and deep learning methods, we explore (a) dimensional and categorical emotion recognition, and (b) PD vs HC classification from emotional EEG signals. Our results reveal that PD patients comprehend arousal better than valence, and amongst emotion categories, \textit{fear}, \textit{disgust} and \textit{surprise} less accurately, and \textit{sadness} most accurately. Mislabeling analyses confirm confounds among opposite-valence emotions with PD data. Emotional EEG responses also achieve near-perfect PD vs HC recognition. {Cumulatively, our study demonstrates that (a) examining \textit{implicit} responses alone enables (i) discovery of valence-related impairments in PD patients, and (ii) differentiation of PD from HC, and (b) emotional EEG analysis is an ecologically-valid, effective, facile and sustainable tool for PD diagnosis vis-á-vis self reports, expert assessments and resting-state analysis.}