Azad Singh

Azad Singh, Deepak Mishra

Self-supervised learning (SSL) has emerged as a promising paradigm for medical image analysis by harnessing unannotated data. Despite their potential, the existing SSL approaches overlook the high anatomical similarity inherent in medical images. This makes it challenging for SSL methods to capture diverse semantic content in medical images consistently. This work introduces a novel and generalized solution that implicitly exploits anatomical similarities by integrating codebooks in SSL. The codebook serves as a concise and informative dictionary of visual patterns, which not only aids in capturing nuanced anatomical details but also facilitates the creation of robust and generalized feature representations. In this context, we propose CoBooM, a novel framework for self-supervised medical image learning by integrating continuous and discrete representations. The continuous component ensures the preservation of fine-grained details, while the discrete aspect facilitates coarse-grained feature extraction through the structured embedding space. To understand the effectiveness of CoBooM, we conduct a comprehensive evaluation of various medical datasets encompassing chest X-rays and fundus images. The experimental results reveal a significant performance gain in classification and segmentation tasks.

Aiman Farooq, Azad Singh, Deepak Mishra et al.

Cancer survival prediction using multi-modal medical imaging presents a critical challenge in oncology, mainly due to the vulnerability of deep learning models to noise and protocol variations across imaging centers. Current approaches struggle to extract consistent features from heterogeneous CT and PET images, limiting their clinical applicability. We address these challenges by introducing RobSurv, a robust deep-learning framework that leverages vector quantization for resilient multi-modal feature learning. The key innovation of our approach lies in its dual-path architecture: one path maps continuous imaging features to learned discrete codebooks for noise-resistant representation, while the parallel path preserves fine-grained details through continuous feature processing. This dual representation is integrated through a novel patch-wise fusion mechanism that maintains local spatial relationships while capturing global context via Transformer-based processing. In extensive evaluations across three diverse datasets (HECKTOR, H\&N1, and NSCLC Radiogenomics), RobSurv demonstrates superior performance, achieving concordance index of 0.771, 0.742, and 0.734 respectively - significantly outperforming existing methods. Most notably, our model maintains robust performance even under severe noise conditions, with performance degradation of only 3.8-4.5\% compared to 8-12\% in baseline methods. These results, combined with strong generalization across different cancer types and imaging protocols, establish RobSurv as a promising solution for reliable clinical prognosis that can enhance treatment planning and patient care.