Yiyang Sun

Yingfan Wang, Yiyang Sun, Haiyang Huang et al.

Dimension reduction (DR) algorithms have proven to be extremely useful for gaining insight into large-scale high-dimensional datasets, particularly finding clusters in transcriptomic data. The initial phase of these DR methods often involves converting the original high-dimensional data into a graph. In this graph, each edge represents the similarity or dissimilarity between pairs of data points. However, this graph is frequently suboptimal due to unreliable high-dimensional distances and the limited information extracted from the high-dimensional data. This problem is exacerbated as the dataset size increases. If we reduce the size of the dataset by selecting points for a specific sections of the embeddings, the clusters observed through DR are more separable since the extracted subgraphs are more reliable. In this paper, we introduce LocalMAP, a new dimensionality reduction algorithm that dynamically and locally adjusts the graph to address this challenge. By dynamically extracting subgraphs and updating the graph on-the-fly, LocalMAP is capable of identifying and separating real clusters within the data that other DR methods may overlook or combine. We demonstrate the benefits of LocalMAP through a case study on biological datasets, highlighting its utility in helping users more accurately identify clusters for real-world problems.

Jing Ma, Yiyang Sun, Junjie Liu et al.

Stroke is the top leading causes of death in China (Zhou et al. The Lancet 2019). A dataset from Shanxi Province is used to identify the risk of each patient's at four states low/medium/high/attack and provide the state transition tendency through a SHAP DeepExplainer. To improve the accuracy on an imbalance sample set, the Quadratic Interactive Deep Neural Network (QIDNN) model is first proposed by flexible selecting and appending of quadratic interactive features. The experimental results showed that the QIDNN model with 7 interactive features achieve the state-of-art accuracy $83.25\%$. Blood pressure, physical inactivity, smoking, weight and total cholesterol are the top five important features. Then, for the sake of high recall on the most urgent state, attack state, the stroke occurrence prediction is taken as an auxiliary objective to benefit from multi-objective optimization. The prediction accuracy was promoted, meanwhile the recall of the attack state was improved by $24.9\%$ (to $84.83\%$) compared to QIDNN (from $67.93\%$) with same features. The prediction model and analysis tool in this paper not only gave the theoretical optimized prediction method, but also provided the attribution explanation of risk states and transition direction of each patient, which provided a favorable tool for doctors to analyze and diagnose the disease.

Junjie Liu, Yiyang Sun, Jing Ma et al.

In China, stroke is the first leading cause of death in recent years. It is a major cause of long-term physical and cognitive impairment, which bring great pressure on the National Public Health System. Evaluation of the risk of getting stroke is important for the prevention and treatment of stroke in China. A data set with 2000 hospitalized stroke patients in 2018 and 27583 residents during the year 2017 to 2020 is analyzed in this study. Due to data incompleteness, inconsistency, and non-structured formats, missing values in the raw data are filled with -1 as an abnormal class. With the cleaned features, three models on risk levels of getting stroke are built by using machine learning methods. The importance of "8+2" factors from China National Stroke Prevention Project (CSPP) is evaluated via decision tree and random forest models. Except for "8+2" factors the importance of features and SHAP1 values for lifestyle information, demographic information, and medical measurement are evaluated and ranked via a random forest model. Furthermore, a logistic regression model is applied to evaluate the probability of getting stroke for different risk levels. Based on the census data in both communities and hospitals from Shanxi Province, we investigate different risk factors of getting stroke and their ranking with interpretable machine learning models. The results show that Hypertension (Systolic blood pressure, Diastolic blood pressure), Physical Inactivity (Lack of sports), and Overweight (BMI) are ranked as the top three high-risk factors of getting stroke in Shanxi province. The probability of getting stroke for a person can also be predicted via our machine learning model.