Hamada R. H. Al-Absi

Farida Mohsen, Hamada R. H. Al-Absi, Noha A. Yousri et al.

The rising prevalence of type 2 diabetes mellitus (T2DM) necessitates the development of predictive models for T2DM risk assessment. Artificial intelligence (AI) models are being extensively used for this purpose, but a comprehensive review of their advancements and challenges is lacking. This scoping review analyzes existing literature on AI-based models for T2DM risk prediction. Forty studies were included, mainly published in the past four years. Traditional machine learning models were more prevalent than deep learning models. Electronic health records were the most commonly used data source. Unimodal AI models relying on EHR data were prominent, while only a few utilized multimodal models. Both unimodal and multimodal models showed promising performance, with the latter outperforming the former. Internal validation was common, while external validation was limited. Interpretability methods were reported in half of the studies. Few studies reported novel biomarkers, and open-source code availability was limited. This review provides insights into the current state and limitations of AI-based T2DM risk prediction models and highlights challenges for their development and clinical implementation.

Junaed Younus Khan, Md. Tawkat Islam Khondaker, Iram Tazim Hoque et al.

We are presenting COVID-19Base, a knowledgebase highlighting the biomedical entities related to COVID-19 disease based on literature mining. To develop COVID-19Base, we mine the information from publicly available scientific literature and related public resources. We considered seven topic-specific dictionaries, including human genes, human miRNAs, human lncRNAs, diseases, Protein Databank, drugs, and drug side effects, are integrated to mine all scientific evidence related to COVID-19. We have employed an automated literature mining and labeling system through a novel approach to measure the effectiveness of drugs against diseases based on natural language processing, sentiment analysis, and deep learning. To the best of our knowledge, this is the first knowledgebase dedicated to COVID-19, which integrates such large variety of related biomedical entities through literature mining. Proper investigation of the mined biomedical entities along with the identified interactions among those, reported in COVID-19Base, would help the research community to discover possible ways for the therapeutic treatment of COVID-19.