Bocheng Guo

Jin Wang, Bocheng Guo, Yijie Li et al.

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial strategy for white matter (WM) parcellation. Current methods primarily use the geometric information of fibers (i.e., the spatial trajectories) to group similar fibers into clusters, overlooking the important functional signals present along the fiber tracts. There is increasing evidence that neural activity in the WM can be measured using functional MRI (fMRI), offering potentially valuable multimodal information for fiber clustering. In this paper, we develop a novel deep learning fiber clustering framework, namely Deep Multi-view Fiber Clustering (DMVFC), that uses joint dMRI and fMRI data to enable functionally consistent WM parcellation. DMVFC can effectively integrate the geometric characteristics of the WM fibers with the fMRI BOLD signals along the fiber tracts. It includes two major components: 1) a multi-view pretraining module to compute embedding features from fiber geometric information and functional signals separately, and 2) a collaborative fine-tuning module to simultaneously refine the two kinds of embeddings. In the experiments, we compare DMVFC with two state-of-the-art fiber clustering methods and demonstrate superior performance in achieving functionally meaningful and consistent WM parcellation results.

Haotian Yan, Bocheng Guo, Jianzhong He et al.

Streamline classification is essential to identify anatomically meaningful white matter tracts from diffusion MRI (dMRI) tractography. However, current streamline classification methods rely primarily on the geometric features of the streamline trajectory, failing to distinguish between functionally distinct fiber tracts with similar pathways. To address this, we introduce a novel dual-stream streamline classification framework that jointly analyzes dMRI and functional MRI (fMRI) data to enhance the functional coherence of tract parcellation. We design a novel network that performs streamline classification using a pretrained backbone model for full streamline trajectories, while augmenting with an auxiliary network that processes fMRI signals from fiber endpoint regions. We demonstrate our method by parcellating the corticospinal tract (CST) into its four somatotopic subdivisions. Experimental results from ablation studies and comparisons with state-of-the-art methods demonstrate our approach's superior performance.

Bocheng Guo, Jin Wang, Yijie Li et al.

Tractography fiber clustering using diffusion MRI (dMRI) is a crucial method for white matter (WM) parcellation to enable analysis of brains structural connectivity in health and disease. Current fiber clustering strategies primarily use the fiber geometric characteristics (i.e., the spatial trajectories) to group similar fibers into clusters, while neglecting the functional and microstructural information of the fiber tracts. There is increasing evidence that neural activity in the WM can be measured using functional MRI (fMRI), providing potentially valuable multimodal information for fiber clustering to enhance its functional coherence. Furthermore, microstructural features such as fractional anisotropy (FA) can be computed from dMRI as additional information to ensure the anatomical coherence of the clusters. In this paper, we develop a novel deep learning fiber clustering framework, namely Deep Multi-view Fiber Clustering (DMVFC), which uses joint multi-modal dMRI and fMRI data to enable functionally consistent WM parcellation. DMVFC can effectively integrate the geometric and microstructural characteristics of the WM fibers with the fMRI BOLD signals along the fiber tracts. DMVFC includes two major components: (1) a multi-view pretraining module to compute embedding features from each source of information separately, including fiber geometry, microstructure measures, and functional signals, and (2) a collaborative fine-tuning module to simultaneously refine the differences of embeddings. In the experiments, we compare DMVFC with two state-of-the-art fiber clustering methods and demonstrate superior performance in achieving functionally meaningful and consistent WM parcellation results.