Florence X. Doo

Pranav Kulkarni, Brajesh K. Lal, Georges Jreij et al.

Accurate characterization of carotid plaques is critical for stroke prevention in patients with carotid stenosis. We analyze 500 plaques from CREST-2, a multi-center clinical trial, to identify radiomics-based markers from B-mode ultrasound images linked with high-risk. We propose a new kernel-based additive model, combining coherence loss with group-sparse regularization for nonlinear classification. Group-wise additive effects of each feature group are visualized using partial dependence plots. Results indicate our method accurately and interpretably assesses plaques, revealing a strong association between plaque texture and clinical risk.

Amit Kumar Kundu, Florence X. Doo, Vaishnavi Patil et al.

Automated mammography screening plays an important role in early breast cancer detection. However, current machine learning models, developed on some training datasets, may exhibit performance degradation and bias when deployed in real-world settings. In this paper, we analyze the performance of high-performing AI models on two mammography datasets-the Emory Breast Imaging Dataset (EMBED) and the RSNA 2022 challenge dataset. Specifically, we evaluate how these models perform across different subgroups, defined by six attributes, to detect potential biases using a range of classification metrics. Our analysis identifies certain subgroups that demonstrate notable underperformance, highlighting the need for ongoing monitoring of these subgroups' performance. To address this, we adopt a monitoring method designed to detect performance drifts over time. Upon identifying a drift, this method issues an alert, which can enable timely interventions. This approach not only provides a tool for tracking the performance but also helps ensure that AI models continue to perform effectively across diverse populations.