Hua Tan

Jianda Yue, Tingting Li, Jian Ouyang et al.

Taste peptides have emerged as promising natural flavoring agents attributed to their unique organoleptic properties, high safety profile, and potential health benefits. However, the de novo identification of taste peptides derived from animal, plant, or microbial sources remains a time-consuming and resource-intensive process, significantly impeding their widespread application in the food industry. Here, we present TastePepAI, a comprehensive artificial intelligence framework for customized taste peptide design and safety assessment. As the key element of this framework, a loss-supervised adaptive variational autoencoder (LA-VAE) is implemented to efficiently optimizes the latent representation of sequences during training and facilitates the generation of target peptides with desired taste profiles. Notably, our model incorporates a novel taste-avoidance mechanism, allowing for selective flavor exclusion. Subsequently, our in-house developed toxicity prediction algorithm (SpepToxPred) is integrated in the framework to undergo rigorous safety evaluation of generated peptides. Using this integrated platform, we successfully identified 73 peptides exhibiting sweet, salty, and umami, significantly expanding the current repertoire of taste peptides. This work demonstrates the potential of TastePepAI in accelerating taste peptide discovery for food applications and provides a versatile framework adaptable to broader peptide engineering challenges.

Yafeng Niu, Dongsheng Zou, Yadong Niu et al.

Speech emotion recognition (SER) is to study the formation and change of speaker's emotional state from the speech signal perspective, so as to make the interaction between human and computer more intelligent. SER is a challenging task that has encountered the problem of less training data and low prediction accuracy. Here we propose a data augmentation algorithm based on the imaging principle of the retina and convex lens, to acquire the different sizes of spectrogram and increase the amount of training data by changing the distance between the spectrogram and the convex lens. Meanwhile, with the help of deep learning to get the high-level features, we propose the Deep Retinal Convolution Neural Networks (DRCNNs) for SER and achieve the average accuracy over 99%. The experimental results indicate that DRCNNs outperforms the previous studies in terms of both the number of emotions and the accuracy of recognition. Predictably, our results will dramatically improve human-computer interaction.