Won‐Jin Moon

Gyutaek Oh, Won-Jin Moon, Jong Chul Ye

DCE-MRI provides information about vascular permeability and tissue perfusion through the acquisition of pharmacokinetic parameters. However, traditional methods for estimating these pharmacokinetic parameters involve fitting tracer kinetic models, which often suffer from computational complexity and low accuracy due to noisy arterial input function (AIF) measurements. Although some deep learning approaches have been proposed to tackle these challenges, most existing methods rely on supervised learning that requires paired input DCE-MRI and labeled pharmacokinetic parameter maps. This dependency on labeled data introduces significant time and resource constraints, as well as potential noise in the labels, making supervised learning methods often impractical. To address these limitations, here we present a novel unpaired deep learning method for estimating both pharmacokinetic parameters and the AIF using a physics-driven CycleGAN approach. Our proposed CycleGAN framework is designed based on the underlying physics model, resulting in a simpler architecture with a single generator and discriminator pair. Crucially, our experimental results indicate that our method, which does not necessitate separate AIF measurements, produces more reliable pharmacokinetic parameters than other techniques.

CH Cho, WJ Moon, W Jun et al.

Partially Relevant Video Retrieval~(PRVR) aims to retrieve a video where a specific segment is relevant to a given text query. Typical training processes of PRVR assume a one-to-one relationship where each text query is relevant to only one video. However, we point out the inherent ambiguity between text and video content based on their conceptual scope and propose a framework that incorporates this ambiguity into the model learning process. Specifically, we propose Ambiguity-Restrained representation Learning~(ARL) to address ambiguous text-video pairs. Initially, ARL detects ambiguous pairs based on two criteria: uncertainty and similarity. Uncertainty represents whether instances include commonly shared context across the dataset, while similarity indicates pair-wise semantic overlap. Then, with the detected ambiguous pairs, our ARL hierarchically learns the semantic relationship via multi-positive contrastive learning and dual triplet margin loss. Additionally, we delve into fine-grained relationships within the video instances. Unlike typical training at the text-video level, where pairwise information is provided, we address the inherent ambiguity within frames of the same untrimmed video, which often contains multiple contexts. This allows us to further enhance learning at the text-frame level. Lastly, we propose cross-model ambiguity detection to mitigate the error propagation that occurs when a single model is employed to detect ambiguous pairs for its training. With all components combined, our proposed method demonstrates its effectiveness in PRVR.

Dongwook Lee, Won-Jin Moon, Jong Chul Ye

Thanks to the recent success of generative adversarial network (GAN) for image synthesis, there are many exciting GAN approaches that successfully synthesize MR image contrast from other images with different contrasts. These approaches are potentially important for image imputation problems, where complete set of data is often difficult to obtain and image synthesis is one of the key solutions for handling the missing data problem. Unfortunately, the lack of the scalability of the existing GAN-based image translation approaches poses a fundamental challenge to understand the nature of the MR contrast imputation problem: which contrast does matter? Here, we present a systematic approach using Collaborative Generative Adversarial Networks (CollaGAN), which enable the learning of the joint image manifold of multiple MR contrasts to investigate which contrasts are essential. Our experimental results showed that the exogenous contrast from contrast agents is not replaceable, but other endogenous contrast such as T1, T2, etc can be synthesized from other contrast. These findings may give important guidance to the acquisition protocol design for MR in real clinical environment.

Dongwook Lee, Junyoung Kim, Won-Jin Moon et al.

In many applications requiring multiple inputs to obtain a desired output, if any of the input data is missing, it often introduces large amounts of bias. Although many techniques have been developed for imputing missing data, the image imputation is still difficult due to complicated nature of natural images. To address this problem, here we proposed a novel framework for missing image data imputation, called Collaborative Generative Adversarial Network (CollaGAN). CollaGAN converts an image imputation problem to a multi-domain images-to-image translation task so that a single generator and discriminator network can successfully estimate the missing data using the remaining clean data set. We demonstrate that CollaGAN produces the images with a higher visual quality compared to the existing competing approaches in various image imputation tasks.