Md. Saiful Bari Siddiqui

Md. Saiful Bari Siddiqui, Md Mohaiminul Islam, Md. Golam Rabiul Alam

Overfitting remains a significant challenge in deep learning, often arising from data outliers, noise, and limited training data. To address this, the Divide2Conquer (D2C) method was previously proposed, which partitions training data into multiple subsets and trains identical models independently on each. This strategy enables learning more consistent patterns while minimizing the influence of individual outliers and noise. However, D2C's standard aggregation typically treats all subset models equally or based on fixed heuristics (like data size), potentially underutilizing information about their varying generalization capabilities. Building upon this foundation, we introduce Dynamic Uncertainty-Aware Divide2Conquer (DUA-D2C), an advanced technique that refines the aggregation process. DUA-D2C dynamically weights the contributions of subset models based on their performance on a shared validation set, considering both accuracy and prediction uncertainty. This intelligent aggregation allows the central model to preferentially learn from subsets yielding more generalizable and confident edge models, thereby more effectively combating overfitting. Empirical evaluations on benchmark datasets spanning multiple domains demonstrate that DUA-D2C significantly improves generalization. Our analysis includes evaluations of decision boundaries, loss curves, and other performance metrics, highlighting the effectiveness of DUA-D2C. This study demonstrates that DUA-D2C improves generalization performance even when applied on top of other regularization methods, establishing it as a theoretically grounded and effective approach to combating overfitting in modern deep learning. Our codes are publicly available at: https://github.com/Saiful185/DUA-D2C.

Md. Saiful Bari Siddiqui, Nowshin Tarannum

Antimicrobial Resistance (AMR) is a rapidly escalating global health crisis. While genomic sequencing enables rapid prediction of resistance phenotypes, current computational methods have limitations. Standard machine learning models treat the genome as an unordered collection of features, ignoring the sequential context of Single Nucleotide Polymorphisms (SNPs). State-of-the-art sequence models like Transformers are often too data-hungry and computationally expensive for the moderately-sized datasets that are typical in this domain. To address these challenges, we propose AMR-EnsembleNet, an ensemble framework that synergistically combines sequence-based and feature-based learning. We developed a lightweight, custom 1D Convolutional Neural Network (CNN) to efficiently learn predictive sequence motifs from high-dimensional SNP data. This sequence-aware model was ensembled with an XGBoost model, a powerful gradient boosting system adept at capturing complex, non-local feature interactions. We trained and evaluated our framework on a benchmark dataset of 809 E. coli strains, predicting resistance across four antibiotics with varying class imbalance. Our 1D CNN-XGBoost ensemble consistently achieved top-tier performance across all the antibiotics, reaching a Matthews Correlation Coefficient (MCC) of 0.926 for Ciprofloxacin (CIP) and the highest Macro F1-score of 0.691 for the challenging Gentamicin (GEN) AMR prediction. We also show that our model consistently focuses on SNPs within well-known AMR genes like fusA and parC, confirming it learns the correct genetic signals for resistance. Our work demonstrates that fusing a sequence-aware 1D CNN with a feature-based XGBoost model creates a powerful ensemble, overcoming the limitations of using either an order-agnostic or a standalone sequence model.

Md. Saiful Bari Siddiqui, Utsab Saha

Biomedical audio signals, such as phonocardiograms (PCG), are inherently rhythmic and contain diagnostic information in both their spectral (tonal) and temporal domains. Standard 2D spectrograms provide rich spectral features but compromise the phase information and temporal precision of the 1D waveform. We propose AudioFuse, an architecture that simultaneously learns from both complementary representations to classify PCGs. To mitigate the overfitting risk common in fusion models, we integrate a custom, wide-and-shallow Vision Transformer (ViT) for spectrograms with a shallow 1D CNN for raw waveforms. On the PhysioNet 2016 dataset, AudioFuse achieves a state-of-the-art competitive ROC-AUC of 0.8608 when trained from scratch, outperforming its spectrogram (0.8066) and waveform (0.8223) baselines. Moreover, it demonstrates superior robustness to domain shift on the challenging PASCAL dataset, maintaining an ROC-AUC of 0.7181 while the spectrogram baseline collapses (0.4873). Fusing complementary representations thus provides a strong inductive bias, enabling the creation of efficient, generalizable classifiers without requiring large-scale pre-training.