Wen Chen

Fangda Li, Zhiqiang Hu, Wen Chen et al.

Immunohistochemical (IHC) staining highlights the molecular information critical to diagnostics in tissue samples. However, compared to H&E staining, IHC staining can be much more expensive in terms of both labor and the laboratory equipment required. This motivates recent research that demonstrates that the correlations between the morphological information present in the H&E-stained slides and the molecular information in the IHC-stained slides can be used for H&E-to-IHC stain translation. However, due to a lack of pixel-perfect H&E-IHC groundtruth pairs, most existing methods have resorted to relying on expert annotations. To remedy this situation, we present a new loss function, Adaptive Supervised PatchNCE (ASP), to directly deal with the input to target inconsistencies in a proposed H&E-to-IHC image-to-image translation framework. The ASP loss is built upon a patch-based contrastive learning criterion, named Supervised PatchNCE (SP), and augments it further with weight scheduling to mitigate the negative impact of noisy supervision. Lastly, we introduce the Multi-IHC Stain Translation (MIST) dataset, which contains aligned H&E-IHC patches for 4 different IHC stains critical to breast cancer diagnosis. In our experiment, we demonstrate that our proposed method outperforms existing image-to-image translation methods for stain translation to multiple IHC stains. All of our code and datasets are available at https://github.com/lifangda01/AdaptiveSupervisedPatchNCE.

Fangda Li, Zhiqiang Hu, Wen Chen et al.

Hematoxylin and Eosin (H&E) staining is a widely used sample preparation procedure for enhancing the saturation of tissue sections and the contrast between nuclei and cytoplasm in histology images for medical diagnostics. However, various factors, such as the differences in the reagents used, result in high variability in the colors of the stains actually recorded. This variability poses a challenge in achieving generalization for machine-learning based computer-aided diagnostic tools. To desensitize the learned models to stain variations, we propose the Generative Stain Augmentation Network (G-SAN) -- a GAN-based framework that augments a collection of cell images with simulated yet realistic stain variations. At its core, G-SAN uses a novel and highly computationally efficient Laplacian Pyramid (LP) based generator architecture, that is capable of disentangling stain from cell morphology. Through the task of patch classification and nucleus segmentation, we show that using G-SAN-augmented training data provides on average 15.7% improvement in F1 score and 7.3% improvement in panoptic quality, respectively. Our code is available at https://github.com/lifangda01/GSAN-Demo.

Wen Chen, Pipei Huang, Jiaming Xu et al.

Increasing demand for fashion recommendation raises a lot of challenges for online shopping platforms and fashion communities. In particular, there exist two requirements for fashion outfit recommendation: the Compatibility of the generated fashion outfits, and the Personalization in the recommendation process. In this paper, we demonstrate these two requirements can be satisfied via building a bridge between outfit generation and recommendation. Through large data analysis, we observe that people have similar tastes in individual items and outfits. Therefore, we propose a Personalized Outfit Generation (POG) model, which connects user preferences regarding individual items and outfits with Transformer architecture. Extensive offline and online experiments provide strong quantitative evidence that our method outperforms alternative methods regarding both compatibility and personalization metrics. Furthermore, we deploy POG on a platform named Dida in Alibaba to generate personalized outfits for the users of the online application iFashion. This work represents a first step towards an industrial-scale fashion outfit generation and recommendation solution, which goes beyond generating outfits based on explicit queries, or merely recommending from existing outfit pools. As part of this work, we release a large-scale dataset consisting of 1.01 million outfits with rich context information, and 0.28 billion user click actions from 3.57 million users. To the best of our knowledge, this dataset is the largest, publicly available, fashion related dataset, and the first to provide user behaviors relating to both outfits and fashion items.