Ziyue Wang

Ziyue Wang, Junde Wu, Linghan Cai et al.

In modern medicine, clinical diagnosis relies on the comprehensive analysis of primarily textual and visual data, drawing on medical expertise to ensure systematic and rigorous reasoning. Recent advances in large Vision-Language Models (VLMs) and agent-based methods hold great potential for medical diagnosis, thanks to the ability to effectively integrate multi-modal patient data. However, they often provide direct answers and draw empirical-driven conclusions without quantitative analysis, which reduces their reliability and clinical usability. We propose MedAgent-Pro, a new agentic reasoning paradigm that follows the diagnosis principle in modern medicine, to decouple the process into sequential components for step-by-step, evidence-based reasoning. Our MedAgent-Pro workflow presents a hierarchical diagnostic structure to mirror this principle, consisting of disease-level standardized plan generation and patient-level personalized step-by-step reasoning. To support disease-level planning, an RAG-based agent is designed to retrieve medical guidelines to ensure alignment with clinical standards. For patient-level reasoning, we propose to integrate professional tools such as visual models to enable quantitative assessments. Meanwhile, we propose to verify the reliability of each step to achieve evidence-based diagnosis, enforcing rigorous logical reasoning and a well-founded conclusion. Extensive experiments across a wide range of anatomical regions, imaging modalities, and diseases demonstrate the superiority of MedAgent-Pro to mainstream VLMs, agentic systems and state-of-the-art expert models. Ablation studies and human evaluation by clinical experts further validate its robustness and clinical relevance. Code is available at https://github.com/jinlab-imvr/MedAgent-Pro.

Yuchang Su, Renping Zhou, Siyu Huang et al.

Generalized Category Discovery (GCD) aims to classify inputs into both known and novel categories, a task crucial for open-world scientific discoveries. However, current GCD methods are limited to unimodal data, overlooking the inherently multimodal nature of most real-world data. In this work, we extend GCD to a multimodal setting, where inputs from different modalities provide richer and complementary information. Through theoretical analysis and empirical validation, we identify that the key challenge in multimodal GCD lies in effectively aligning heterogeneous information across modalities. To address this, we propose MM-GCD, a novel framework that aligns both the feature and output spaces of different modalities using contrastive learning and distillation techniques. MM-GCD achieves new state-of-the-art performance on the UPMC-Food101 and N24News datasets, surpassing previous methods by 11.5\% and 4.7\%, respectively.

Xiaolong Wang, Yuanchi Zhang, Ziyue Wang et al. · tsinghua

Large language models (LLMs) have revolutionized the field of natural language processing, enabling remarkable progress in various tasks. Different from objective tasks such as commonsense reasoning and arithmetic question-answering, the performance of LLMs on subjective tasks is still limited, where the perspective on the specific problem plays crucial roles for better interpreting the context and giving proper response. For example, in certain scenarios, LLMs may perform better when answering from an expert role perspective, potentially eliciting their relevant domain knowledge. In contrast, in some scenarios, LLMs may provide more accurate responses when answering from a third-person standpoint, enabling a more comprehensive understanding of the problem and potentially mitigating inherent biases. In this paper, we propose Reasoning through Perspective Transition (RPT), a method based on in-context learning that enables LLMs to dynamically select among direct, role, and third-person perspectives for the best way to solve corresponding subjective problem. Through extensive experiments on totally 12 subjective tasks by using both closed-source and open-source LLMs including GPT-4, GPT-3.5, Llama-3, and Qwen-2, our method outperforms widely used single fixed perspective based methods such as chain-of-thought prompting and expert prompting, highlights the intricate ways that LLMs can adapt their perspectives to provide nuanced and contextually appropriate responses for different problems.

Ye Zhang, Yu Zhou, Yifeng Wang et al.

Cell instance segmentation is critical to analyzing biomedical images, yet accurately distinguishing tightly touching cells remains a persistent challenge. Existing instance segmentation frameworks, including detection-based, contour-based, and distance mapping-based approaches, have made significant progress, but balancing model performance with computational efficiency remains an open problem. In this paper, we propose a novel cell instance segmentation method inspired by the four-color theorem. By conceptualizing cells as countries and tissues as oceans, we introduce a four-color encoding scheme that ensures adjacent instances receive distinct labels. This reformulation transforms instance segmentation into a constrained semantic segmentation problem with only four predicted classes, substantially simplifying the instance differentiation process. To solve the training instability caused by the non-uniqueness of four-color encoding, we design an asymptotic training strategy and encoding transformation method. Extensive experiments on various modes demonstrate our approach achieves state-of-the-art performance. The code is available at https://github.com/zhangye-zoe/FCIS.

Ziyue Wang, Yurui Dong, Fuwen Luo et al.

The rapid advancing of Multimodal Large Language Models (MLLMs) has spurred interest in complex multimodal reasoning tasks in the real-world and virtual environment, which require coordinating multiple abilities, including visual perception, visual reasoning, spatial awareness, and target deduction. However, existing evaluations primarily assess the final task completion, often degrading assessments to isolated abilities such as visual grounding and visual question answering. Less attention is given to comprehensively and quantitatively analyzing reasoning process in multimodal environments, which is crucial for understanding model behaviors and underlying reasoning mechanisms beyond merely task success. To address this, we introduce MM-Escape, an extensible benchmark for investigating multimodal reasoning, inspired by real-world escape games. MM-Escape emphasizes intermediate model behaviors alongside final task completion. To achieve this, we develop EscapeCraft, a customizable and open environment that enables models to engage in free-form exploration for assessing multimodal reasoning. Extensive experiments show that MLLMs, regardless of scale, can successfully complete the simplest room escape tasks, with some exhibiting human-like exploration strategies. Yet, performance dramatically drops as task difficulty increases. Moreover, we observe that performance bottlenecks vary across models, revealing distinct failure modes and limitations in their multimodal reasoning abilities, such as repetitive trajectories without adaptive exploration, getting stuck in corners due to poor visual spatial awareness, and ineffective use of acquired props, such as the key. We hope our work sheds light on new challenges in multimodal reasoning, and uncovers potential improvements in MLLMs capabilities.

Guanyi Qin, Ziyue Wang, Daiyun Shen et al.

Given an object mask, Semi-supervised Video Object Segmentation (SVOS) technique aims to track and segment the object across video frames, serving as a fundamental task in computer vision. Although recent memory-based methods demonstrate potential, they often struggle with scenes involving occlusion, particularly in handling object interactions and high feature similarity. To address these issues and meet the real-time processing requirements of downstream applications, in this paper, we propose a novel bOundary Amendment video object Segmentation method with Inherent Structure refinement, hereby named OASIS. Specifically, a lightweight structure refinement module is proposed to enhance segmentation accuracy. With the fusion of rough edge priors captured by the Canny filter and stored object features, the module can generate an object-level structure map and refine the representations by highlighting boundary features. Evidential learning for uncertainty estimation is introduced to further address challenges in occluded regions. The proposed method, OASIS, maintains an efficient design, yet extensive experiments on challenging benchmarks demonstrate its superior performance and competitive inference speed compared to other state-of-the-art methods, i.e., achieving the F values of 91.6 (vs. 89.7 on DAVIS-17 validation set) and G values of 86.6 (vs. 86.2 on YouTubeVOS 2019 validation set) while maintaining a competitive speed of 48 FPS on DAVIS.