Saiyang Na

Qifeng Zhou, Thao M. Dang, Wenliang Zhong et al.

Pathology plays a critical role in diagnosing a wide range of diseases, yet existing approaches often rely heavily on task-specific models trained on extensive, well-labeled datasets. These methods face sustainability challenges due to the diversity of pathologies and the labor-intensive nature of data collection. To address these limitations, we highlight the need for universal multimodal embeddings that can support multiple downstream tasks. Previous approaches involve fine-tuning CLIP-based models, which handle images and texts separately, limiting their ability to capture complex multimodal relationships. Additionally, these models are evaluated across diverse datasets without a unified benchmark. In this paper, we explore the possibility of applying Multimodal Large Language Models (MLLMs) to generate pathology universal embeddings to address these challenges. Our contributions can be summarized in the following aspects: 1) We propose MLLM4PUE, a novel framework that leverages MLLMs to generate embeddings for various pathology downstream tasks. 2) We further introduce the Pathology Multimodal Embedding Benchmark (PMEB), a comprehensive benchmark designed to assess the quality of pathology multimodal embeddings, which comprises 16 original tasks drawn from 15 datasets. 3) Extensive experimental results demonstrate the superiority of MLLM4PUE, illustrating MLLM-based models can effectively support a wide range of downstream tasks and unify the research direction for foundation models in pathology.

Saiyang Na, Yuzhi Guo, Feng Jiang et al.

In the rapidly evolving field of AI research, foundational models like BERT and GPT have significantly advanced language and vision tasks. The advent of pretrain-prompting models such as ChatGPT and Segmentation Anything Model (SAM) has further revolutionized image segmentation. However, their applications in specialized areas, particularly in nuclei segmentation within medical imaging, reveal a key challenge: the generation of high-quality, informative prompts is as crucial as applying state-of-the-art (SOTA) fine-tuning techniques on foundation models. To address this, we introduce Segment Any Cell (SAC), an innovative framework that enhances SAM specifically for nuclei segmentation. SAC integrates a Low-Rank Adaptation (LoRA) within the attention layer of the Transformer to improve the fine-tuning process, outperforming existing SOTA methods. It also introduces an innovative auto-prompt generator that produces effective prompts to guide segmentation, a critical factor in handling the complexities of nuclei segmentation in biomedical imaging. Our extensive experiments demonstrate the superiority of SAC in nuclei segmentation tasks, proving its effectiveness as a tool for pathologists and researchers. Our contributions include a novel prompt generation strategy, automated adaptability for diverse segmentation tasks, the innovative application of Low-Rank Attention Adaptation in SAM, and a versatile framework for semantic segmentation challenges.