Elliott Pryor

Elliott C. Pryor, Marc D. Breton, Anas El Fathi

Diabetes devices, including Continuous Glucose Monitoring (CGM), Smart Insulin Pens, and Automated Insulin Delivery systems, generate rich time-series data widely used in research and machine learning. However, inconsistent data formats across sources hinder sharing, integration, and analysis. We present DIAX (DIAbetes eXchange), a standardized JSON-based format for unifying diabetes time-series data, including CGM, insulin, and meal signals. DIAX promotes interoperability, reproducibility, and extensibility, particularly for machine learning applications. An open-source repository provides tools for dataset conversion, cross-format compatibility, visualization, and community contributions. DIAX is a translational resource, not a data host, ensuring flexibility without imposing data-sharing constraints. Currently, DIAX is compatible with other standardization efforts and supports major datasets (DCLP3, DCLP5, IOBP2, PEDAP, T1Dexi, Loop), totaling over 10 million patient-hours of data. https://github.com/Center-for-Diabetes-Technology/DIAX

Alberto Castillo, Elliot Pryor, Anas El Fathi et al.

Training Neural Networks (NNs) to behave as Model Predictive Control (MPC) algorithms is an effective way to implement them in constrained embedded devices. By collecting large amounts of input-output data, where inputs represent system states and outputs are MPC-generated control actions, NNs can be trained to replicate MPC behavior at a fraction of the computational cost. However, although the composition of the training data critically influences the final NN accuracy, methods for systematically optimizing it remain underexplored. In this paper, we introduce the concept of Optimally-Sampled Datasets (OSDs) as ideal training sets and present an efficient algorithm for generating them. An OSD is a parametrized subset of all the available data that (i) preserves existing MPC information up to a certain numerical resolution, (ii) avoids duplicate or near-duplicate states, and (iii) becomes saturated or complete. We demonstrate the effectiveness of OSDs by training NNs to replicate the University of Virginia's MPC algorithm for automated insulin delivery in Type-1 Diabetes, achieving a four-fold improvement in final accuracy. Notably, two OSD-trained NNs received regulatory clearance for clinical testing as the first NN-based control algorithm for direct human insulin dosing. This methodology opens new pathways for implementing advanced optimizations on resource-constrained embedded platforms, potentially revolutionizing how complex algorithms are deployed.

Anas El Fathi, Elliott Pryor, Marc D. Breton

Calculating mealtime insulin doses poses a significant challenge for individuals with Type 1 Diabetes (T1D). Doses should perfectly compensate for expected post-meal glucose excursions, requiring a profound understanding of the individual's insulin sensitivity and the meal macronutrients'. Usually, people rely on intuition and experience to develop this understanding. In this work, we demonstrate how a reinforcement learning agent, employing a self-attention encoder network, can effectively mimic and enhance this intuitive process. Trained on 80 virtual subjects from the FDA-approved UVA/Padova T1D adult cohort and tested on twenty, self-attention demonstrates superior performance compared to other network architectures. Results reveal a significant reduction in glycemic risk, from 16.5 to 9.6 in scenarios using sensor-augmented pump and from 9.1 to 6.7 in scenarios using automated insulin delivery. This new paradigm bypasses conventional therapy parameters, offering the potential to simplify treatment and promising improved quality of life and glycemic outcomes for people with T1D.