Bowen Ding

Hao Li, Ying Chen, Yifei Chen et al.

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods leverage coarse-grained pathogenetic descriptions for visual representation supervision, which are insufficient to capture the complex visual appearance of pathogenetic images, hindering the generalizability of models on diverse downstream tasks. Additionally, processing high-resolution WSIs can be computationally expensive. In this paper, we propose a novel "Fine-grained Visual-Semantic Interaction" (FiVE) framework for WSI classification. It is designed to enhance the model's generalizability by leveraging the interaction between localized visual patterns and fine-grained pathological semantics. Specifically, with meticulously designed queries, we start by utilizing a large language model to extract fine-grained pathological descriptions from various non-standardized raw reports. The output descriptions are then reconstructed into fine-grained labels used for training. By introducing a Task-specific Fine-grained Semantics (TFS) module, we enable prompts to capture crucial visual information in WSIs, which enhances representation learning and augments generalization capabilities significantly. Furthermore, given that pathological visual patterns are redundantly distributed across tissue slices, we sample a subset of visual instances during training. Our method demonstrates robust generalizability and strong transferability, dominantly outperforming the counterparts on the TCGA Lung Cancer dataset with at least 9.19% higher accuracy in few-shot experiments. The code is available at: https://github.com/ls1rius/WSI_FiVE.

Xiao Yang, Enmin Song, Guangzhi Ma et al.

Colon cancer is expected to become the second leading cause of cancer death in the United States in 2023. Although colonoscopy is one of the most effective methods for early prevention of colon cancer, up to 30% of polyps may be missed by endoscopists, thereby increasing patients' risk of developing colon cancer. Though deep neural networks have been proven to be an effective means of enhancing the detection rate of polyps. However, the variation of polyp size brings the following problems: (1) it is difficult to design an efficient and sufficient multi-scale feature fusion structure; (2) matching polyps of different sizes with fixed-size anchor boxes is a hard challenge. These problems reduce the performance of polyp detection and also lower the model's training and detection efficiency. To address these challenges, this paper proposes a new model called YOLO-OB. Specifically, we developed a bidirectional multiscale feature fusion structure, BiSPFPN, which could enhance the feature fusion capability across different depths of a CNN. We employed the ObjectBox detection head, which used a center-based anchor-free box regression strategy that could detect polyps of different sizes on feature maps of any scale. Experiments on the public dataset SUN and the self-collected colon polyp dataset Union demonstrated that the proposed model significantly improved various performance metrics of polyp detection, especially the recall rate. Compared to the state-of-the-art results on the public dataset SUN, the proposed method achieved a 6.73% increase on recall rate from 91.5% to 98.23%. Furthermore, our YOLO-OB was able to achieve real-time polyp detection at a speed of 39 frames per second using a RTX3090 graphics card. The implementation of this paper can be found here: https://github.com/seanyan62/YOLO-OB.

Kedi Chen, Qin Chen, Jie Zhou et al.

Large Language Models (LLMs) are prone to hallucination with non-factual or unfaithful statements, which undermines the applications in real-world scenarios. Recent researches focus on uncertainty-based hallucination detection, which utilizes the output probability of LLMs for uncertainty calculation and does not rely on external knowledge or frequent sampling from LLMs. Whereas, most approaches merely consider the uncertainty of each independent token, while the intricate semantic relations among tokens and sentences are not well studied, which limits the detection of hallucination that spans over multiple tokens and sentences in the passage. In this paper, we propose a method to enhance uncertainty modeling with semantic graph for hallucination detection. Specifically, we first construct a semantic graph that well captures the relations among entity tokens and sentences. Then, we incorporate the relations between two entities for uncertainty propagation to enhance sentence-level hallucination detection. Given that hallucination occurs due to the conflict between sentences, we further present a graph-based uncertainty calibration method that integrates the contradiction probability of the sentence with its neighbors in the semantic graph for uncertainty calculation. Extensive experiments on two datasets show the great advantages of our proposed approach. In particular, we obtain substantial improvements with 19.78% in passage-level hallucination detection.