Yingying Zhu

Yingying Zhu, Hongji Yang, Yuxin Lu et al.

In this work, we aim at an important but less explored problem of a simple yet effective backbone specific for cross-view geo-localization task. Existing methods for cross-view geo-localization tasks are frequently characterized by 1) complicated methodologies, 2) GPU-consuming computations, and 3) a stringent assumption that aerial and ground images are centrally or orientation aligned. To address the above three challenges for cross-view image matching, we propose a new backbone network, named Simple Attention-based Image Geo-localization network (SAIG). The proposed SAIG effectively represents long-range interactions among patches as well as cross-view correspondence with multi-head self-attention layers. The "narrow-deep" architecture of our SAIG improves the feature richness without degradation in performance, while its shallow and effective convolutional stem preserves the locality, eliminating the loss of patchify boundary information. Our SAIG achieves state-of-the-art results on cross-view geo-localization, while being far simpler than previous works. Furthermore, with only 15.9% of the model parameters and half of the output dimension compared to the state-of-the-art, the SAIG adapts well across multiple cross-view datasets without employing any well-designed feature aggregation modules or feature alignment algorithms. In addition, our SAIG attains competitive scores on image retrieval benchmarks, further demonstrating its generalizability. As a backbone network, our SAIG is both easy to follow and computationally lightweight, which is meaningful in practical scenario. Moreover, we propose a simple Spatial-Mixed feature aggregation moDule (SMD) that can mix and project spatial information into a low-dimensional space to generate feature descriptors... (The code is available at https://github.com/yanghongji2007/SAIG)

Ziteng Cui, Yingying Zhu, Lin Gu et al.

Image restoration algorithms such as super resolution (SR) are indispensable pre-processing modules for object detection in low quality images. Most of these algorithms assume the degradation is fixed and known a priori. However, in practical, either the real degradation or optimal up-sampling ratio rate is unknown or differs from assumption, leading to a deteriorating performance for both the pre-processing module and the consequent high-level task such as object detection. Here, we propose a novel self-supervised framework to detect objects in degraded low resolution images. We utilizes the downsampling degradation as a kind of transformation for self-supervised signals to explore the equivariant representation against various resolutions and other degradation conditions. The Auto Encoding Resolution in Self-supervision (AERIS) framework could further take the advantage of advanced SR architectures with an arbitrary resolution restoring decoder to reconstruct the original correspondence from the degraded input image. Both the representation learning and object detection are optimized jointly in an end-to-end training fashion. The generic AERIS framework could be implemented on various mainstream object detection architectures with different backbones. The extensive experiments show that our methods has achieved superior performance compared with existing methods when facing variant degradation situations. Code would be released at https://github.com/cuiziteng/ECCV_AERIS.

Xinyue Hu, Lin Gu, Qiyuan An et al.

To contribute to automating the medical vision-language model, we propose a novel Chest-Xray Difference Visual Question Answering (VQA) task. Given a pair of main and reference images, this task attempts to answer several questions on both diseases and, more importantly, the differences between them. This is consistent with the radiologist's diagnosis practice that compares the current image with the reference before concluding the report. We collect a new dataset, namely MIMIC-Diff-VQA, including 700,703 QA pairs from 164,324 pairs of main and reference images. Compared to existing medical VQA datasets, our questions are tailored to the Assessment-Diagnosis-Intervention-Evaluation treatment procedure used by clinical professionals. Meanwhile, we also propose a novel expert knowledge-aware graph representation learning model to address this task. The proposed baseline model leverages expert knowledge such as anatomical structure prior, semantic, and spatial knowledge to construct a multi-relationship graph, representing the image differences between two images for the image difference VQA task. The dataset and code can be found at https://github.com/Holipori/MIMIC-Diff-VQA. We believe this work would further push forward the medical vision language model.

Xinyue Hu, Lin Gu, Kazuma Kobayashi et al.

Medical visual question answering (VQA) aims to answer clinically relevant questions regarding input medical images. This technique has the potential to improve the efficiency of medical professionals while relieving the burden on the public health system, particularly in resource-poor countries. Existing medical VQA methods tend to encode medical images and learn the correspondence between visual features and questions without exploiting the spatial, semantic, or medical knowledge behind them. This is partially because of the small size of the current medical VQA dataset, which often includes simple questions. Therefore, we first collected a comprehensive and large-scale medical VQA dataset, focusing on chest X-ray images. The questions involved detailed relationships, such as disease names, locations, levels, and types in our dataset. Based on this dataset, we also propose a novel baseline method by constructing three different relationship graphs: spatial relationship, semantic relationship, and implicit relationship graphs on the image regions, questions, and semantic labels. The answer and graph reasoning paths are learned for different questions.

Liangchen Liu, Qiuhong Ke, Chaojie Li et al.

Spectral clustering is an effective methodology for unsupervised learning. Most traditional spectral clustering algorithms involve a separate two-step procedure and apply the transformed new representations for the final clustering results. Recently, much progress has been made to utilize the non-negative feature property in real-world data and to jointly learn the representation and clustering results. However, to our knowledge, no previous work considers a unified model that incorporates the important multi-view information with those properties, which severely limits the performance of existing methods. In this paper, we formulate a novel clustering model, which exploits the non-negative feature property and, more importantly, incorporates the multi-view information into a unified joint learning framework: the unified multi-view orthonormal non-negative graph based clustering framework (Umv-ONGC). Then, we derive an effective three-stage iterative solution for the proposed model and provide analytic solutions for the three sub-problems from the three stages. We also explore, for the first time, the multi-model non-negative graph-based approach to clustering data based on deep features. Extensive experiments on three benchmark data sets demonstrate the effectiveness of the proposed method.

Zhanyuan Yang, Jinghua Wang, Yingying Zhu

A two-stage training paradigm consisting of sequential pre-training and meta-training stages has been widely used in current few-shot learning (FSL) research. Many of these methods use self-supervised learning and contrastive learning to achieve new state-of-the-art results. However, the potential of contrastive learning in both stages of FSL training paradigm is still not fully exploited. In this paper, we propose a novel contrastive learning-based framework that seamlessly integrates contrastive learning into both stages to improve the performance of few-shot classification. In the pre-training stage, we propose a self-supervised contrastive loss in the forms of feature vector vs. feature map and feature map vs. feature map, which uses global and local information to learn good initial representations. In the meta-training stage, we propose a cross-view episodic training mechanism to perform the nearest centroid classification on two different views of the same episode and adopt a distance-scaled contrastive loss based on them. These two strategies force the model to overcome the bias between views and promote the transferability of representations. Extensive experiments on three benchmark datasets demonstrate that our method achieves competitive results.

Mengliang Zhang, Xinyue Hu, Lin Gu et al.

Patients undergoing chest X-rays (CXR) often endure multiple lung diseases. When evaluating a patient's condition, due to the complex pathologies, subtle texture changes of different lung lesions in images, and patient condition differences, radiologists may make uncertain even when they have experienced long-term clinical training and professional guidance, which makes much noise in extracting disease labels based on CXR reports. In this paper, we re-extract disease labels from CXR reports to make them more realistic by considering disease severity and uncertainty in classification. Our contributions are as follows: 1. We re-extracted the disease labels with severity and uncertainty by a rule-based approach with keywords discussed with clinical experts. 2. To further improve the explainability of chest X-ray diagnosis, we designed a multi-relationship graph learning method with an expert uncertainty-aware loss function. 3. Our multi-relationship graph learning method can also interpret the disease classification results. Our experimental results show that models considering disease severity and uncertainty outperform previous state-of-the-art methods.

Xinyue Hu, Lin Gu, Liangchen Liu et al.

Existing video domain adaption (DA) methods need to store all temporal combinations of video frames or pair the source and target videos, which are memory cost expensive and can't scale up to long videos. To address these limitations, we propose a memory-efficient graph-based video DA approach as follows. At first our method models each source or target video by a graph: nodes represent video frames and edges represent the temporal or visual similarity relationship between frames. We use a graph attention network to learn the weight of individual frames and simultaneously align the source and target video into a domain-invariant graph feature space. Instead of storing a large number of sub-videos, our method only constructs one graph with a graph attention mechanism for one video, reducing the memory cost substantially. The extensive experiments show that, compared with the state-of-art methods, we achieved superior performance while reducing the memory cost significantly.

Mingkun Yang, Biao Yang, Minghui Liao et al.

Scene text recognition is a rapidly developing field that faces numerous challenges due to the complexity and diversity of scene text, including complex backgrounds, diverse fonts, flexible arrangements, and accidental occlusions. In this paper, we propose a novel approach called Class-Aware Mask-guided feature refinement (CAM) to address these challenges. Our approach introduces canonical class-aware glyph masks generated from a standard font to effectively suppress background and text style noise, thereby enhancing feature discrimination. Additionally, we design a feature alignment and fusion module to incorporate the canonical mask guidance for further feature refinement for text recognition. By enhancing the alignment between the canonical mask feature and the text feature, the module ensures more effective fusion, ultimately leading to improved recognition performance. We first evaluate CAM on six standard text recognition benchmarks to demonstrate its effectiveness. Furthermore, CAM exhibits superiority over the state-of-the-art method by an average performance gain of 4.1% across six more challenging datasets, despite utilizing a smaller model size. Our study highlights the importance of incorporating canonical mask guidance and aligned feature refinement techniques for robust scene text recognition. The code is available at https://github.com/MelosY/CAM.

Ling Fu, Zijie Wu, Yingying Zhu et al.

Scene text detection techniques have garnered significant attention due to their wide-ranging applications. However, existing methods have a high demand for training data, and obtaining accurate human annotations is labor-intensive and time-consuming. As a solution, researchers have widely adopted synthetic text images as a complementary resource to real text images during pre-training. Yet there is still room for synthetic datasets to enhance the performance of scene text detectors. We contend that one main limitation of existing generation methods is the insufficient integration of foreground text with the background. To alleviate this problem, we present the Diffusion Model based Text Generator (DiffText), a pipeline that utilizes the diffusion model to seamlessly blend foreground text regions with the background's intrinsic features. Additionally, we propose two strategies to generate visually coherent text with fewer spelling errors. With fewer text instances, our produced text images consistently surpass other synthetic data in aiding text detectors. Extensive experiments on detecting horizontal, rotated, curved, and line-level texts demonstrate the effectiveness of DiffText in producing realistic text images.

Xiaoyan Zhang, Gaoyang Tang, Yingying Zhu et al.

The issue of image haze removal has attracted wide attention in recent years. However, most existing haze removal methods cannot restore the scene with clear blue sky, since the color and texture information of the object in the original haze image is insufficient. To remedy this, we propose a cycle generative adversarial network to construct a novel end-to-end image dehaze model. We adopt outdoor image datasets to train our model, which includes a set of real-world unpaired image dataset and a set of paired image dataset to ensure that the generated images are close to the real scene. Based on the cycle structure, our model adds four different kinds of loss function to constrain the effect including adversarial loss, cycle consistency loss, photorealism loss and paired L1 loss. These four constraints can improve the overall quality of such degraded images for better visual appeal and ensure reconstruction of images to keep from distortion. The proposed model could remove the haze of images and also restore the sky of images to be clean and blue (like captured in a sunny weather).

Xiangyu Peng, Kai Wang, Jianfei Yang et al.

With the advance of deep learning, much progress has been made in building powerful artificial intelligence (AI) systems for automatic Chest X-ray (CXR) analysis. Most existing AI models are trained to be a binary classifier with the aim of distinguishing positive and negative cases. However, a large gap exists between the simple binary setting and complicated real-world medical scenarios. In this work, we reinvestigate the problem of automatic radiology diagnosis. We first observe that there is considerable diversity among cases within the positive class, which means simply classifying them as positive loses many important details. This motivates us to build AI models that can communicate fine-grained knowledge from medical images like human experts. To this end, we first propose a new benchmark on fine granularity learning from medical images. Specifically, we devise a division rule based on medical knowledge to divide positive cases into two subcategories, namely atypical positive and typical positive. Then, we propose a new metric termed AUC$^\text{FG}$ on the two subcategories for evaluation of the ability to separate them apart. With the proposed benchmark, we encourage the community to develop AI diagnosis systems that could better learn fine granularity from medical images. Last, we propose a simple risk modulation approach to this problem by only using coarse labels in training. Empirical results show that despite its simplicity, the proposed method achieves superior performance and thus serves as a strong baseline.

Songsong Ouyang, Yingying Zhu

Cross-view geo-localization (CVGL) aims to estimate the geographic location of a street image by matching it with a corresponding aerial image. This is critical for autonomous navigation and mapping in complex real-world scenarios. However, the task remains challenging due to significant viewpoint differences and the influence of confounding factors. To tackle these issues, we propose the Causal Learning and Geometric Topology (CLGT) framework, which integrates two key components: a Causal Feature Extractor (CFE) that mitigates the influence of confounding factors by leveraging causal intervention to encourage the model to focus on stable, task-relevant semantics; and a Geometric Topology Fusion (GT Fusion) module that injects Bird's Eye View (BEV) road topology into street features to alleviate cross-view inconsistencies caused by extreme perspective changes. Additionally, we introduce a Data-Adaptive Pooling (DA Pooling) module to enhance the representation of semantically rich regions. Extensive experiments on CVUSA, CVACT, and their robustness-enhanced variants (CVUSA-C-ALL and CVACT-C-ALL) demonstrate that CLGT achieves state-of-the-art performance, particularly under challenging real-world corruptions. Our codes are available at https://github.com/oyss-szu/CLGT.

Fukang Ge, Jiarui Zhu, Linjie Zhang et al.

Modern AI technologies for drug discovery are distributed across heterogeneous platforms-including web applications, desktop environments, and code libraries-leading to fragmented workflows, inconsistent interfaces, and high integration overhead. We present an agentic end-to-end drug design framework that leverages a Large Language Model (LLM) in conjunction with the Model Context Protocol (MCP) to dynamically coordinate access to biochemical databases, modular toolchains, and task-specific AI models. The system integrates four state-of-the-art components: MaSIF (MaSIF-site and MaSIF-seed-search) for geometric deep learning-based identification of protein-protein interaction (PPI) sites, Rosetta for grafting protein fragments onto protein backbones to form mini proteins, ProteinMPNN for amino acid sequences redesign, and AlphaFold3 for near-experimental accuracy in complex structure prediction. Starting from a target structure, the framework supports de novo binder generation via surface analysis, scaffold grafting and pose construction, sequence optimization, and structure prediction. Additionally, by replacing rigid, script-based workflows with a protocol-driven, LLM-coordinated architecture, the framework improves reproducibility, reduces manual overhead, and ensures extensibility, portability, and auditability across the entire drug design process.

Xinyu Wang, Jinghua Hou, Zhe Liu et al.

Transformer-based methods have demonstrated remarkable capabilities in 3D semantic segmentation through their powerful attention mechanisms, but the quadratic complexity limits their modeling of long-range dependencies in large-scale point clouds. While recent Mamba-based approaches offer efficient processing with linear complexity, they struggle with feature representation when extracting 3D features. However, effectively combining these complementary strengths remains an open challenge in this field. In this paper, we propose HybridTM, the first hybrid architecture that integrates Transformer and Mamba for 3D semantic segmentation. In addition, we propose the Inner Layer Hybrid Strategy, which combines attention and Mamba at a finer granularity, enabling simultaneous capture of long-range dependencies and fine-grained local features. Extensive experiments demonstrate the effectiveness and generalization of our HybridTM on diverse indoor and outdoor datasets. Furthermore, our HybridTM achieves state-of-the-art performance on ScanNet, ScanNet200, and nuScenes benchmarks. The code will be made available at https://github.com/deepinact/HybridTM.

Dingkang Liang, Wei Xu, Yingying Zhu et al.

In this paper, we focus on the crowd localization task, a crucial topic of crowd analysis. Most regression-based methods utilize convolution neural networks (CNN) to regress a density map, which can not accurately locate the instance in the extremely dense scene, attributed to two crucial reasons: 1) the density map consists of a series of blurry Gaussian blobs, 2) severe overlaps exist in the dense region of the density map. To tackle this issue, we propose a novel Focal Inverse Distance Transform (FIDT) map for the crowd localization task. Compared with the density maps, the FIDT maps accurately describe the persons' locations without overlapping in dense regions. Based on the FIDT maps, a Local-Maxima-Detection-Strategy (LMDS) is derived to effectively extract the center point for each individual. Furthermore, we introduce an Independent SSIM (I-SSIM) loss to make the model tend to learn the local structural information, better recognizing local maxima. Extensive experiments demonstrate that the proposed method reports state-of-the-art localization performance on six crowd datasets and one vehicle dataset. Additionally, we find that the proposed method shows superior robustness on the negative and extremely dense scenes, which further verifies the effectiveness of the FIDT maps. The code and model will be available at https://github.com/dk-liang/FIDTM.

Yifan Peng, Yu-Xing Tang, Sungwon Lee et al.

The latest threat to global health is the COVID-19 outbreak. Although there exist large datasets of chest X-rays (CXR) and computed tomography (CT) scans, few COVID-19 image collections are currently available due to patient privacy. At the same time, there is a rapid growth of COVID-19-relevant articles in the biomedical literature. Here, we present COVID-19-CT-CXR, a public database of COVID-19 CXR and CT images, which are automatically extracted from COVID-19-relevant articles from the PubMed Central Open Access (PMC-OA) Subset. We extracted figures, associated captions, and relevant figure descriptions in the article and separated compound figures into subfigures. We also designed a deep-learning model to distinguish them from other figure types and to classify them accordingly. The final database includes 1,327 CT and 263 CXR images (as of May 9, 2020) with their relevant text. To demonstrate the utility of COVID-19-CT-CXR, we conducted four case studies. (1) We show that COVID-19-CT-CXR, when used as additional training data, is able to contribute to improved DL performance for the classification of COVID-19 and non-COVID-19 CT. (2) We collected CT images of influenza and trained a DL baseline to distinguish a diagnosis of COVID-19, influenza, or normal or other types of diseases on CT. (3) We trained an unsupervised one-class classifier from non-COVID-19 CXR and performed anomaly detection to detect COVID-19 CXR. (4) From text-mined captions and figure descriptions, we compared clinical symptoms and clinical findings of COVID-19 vs. those of influenza to demonstrate the disease differences in the scientific publications. We believe that our work is complementary to existing resources and hope that it will contribute to medical image analysis of the COVID-19 pandemic. The dataset, code, and DL models are publicly available at https://github.com/ncbi-nlp/COVID-19-CT-CXR.

Bo Lv, Qingwang Zhang, Le Wu et al.

Cross-View Object Geo-Localization (CVOGL) aims to locate an object of interest in a query image within a corresponding satellite image. Existing methods typically assume that the query image contains only a single object, which does not align with the complex, multi-object geo-localization requirements in real-world applications, making them unsuitable for practical scenarios. To bridge the gap between the realistic setting and existing task, we propose a new task, called Cross-View Multi-Object Geo-Localization (CVMOGL). To advance the CVMOGL task, we first construct a benchmark, CMLocation, which includes two datasets: CMLocation-V1 and CMLocation-V2. Furthermore, we propose a novel cross-view multi-object geo-localization method, MOGeo, and benchmark it against existing state-of-the-art methods. Extensive experiments are conducted under various application scenarios to validate the effectiveness of our method. The results demonstrate that cross-view object geo-localization in the more realistic setting remains a challenging problem, encouraging further research in this area.

Linger Deng, Linghao Zhu, Yuliang Liu et al.

Large Multimodal Models (LMMs) face limitations in geometric reasoning due to insufficient Chain of Thought (CoT) image-text training data. While existing approaches leverage template-based or LLM-assisted methods for geometric CoT data creation, they often face challenges in achieving both diversity and precision. To bridge this gap, we introduce a two-stage Theorem-Validated Reverse Chain-of-Thought Reasoning Synthesis (TR-CoT) framework. The first stage, TR-Engine, synthesizes theorem-grounded geometric diagrams with structured descriptions and properties. The second stage, TR-Reasoner, employs reverse reasoning to iteratively refine question-answer pairs by cross-validating geometric properties and description fragments. Our approach expands theorem-type coverage, corrects long-standing misunderstandings, and enhances geometric reasoning. Fine-grained CoT improves theorem understanding and increases logical consistency by 24.5%. Our best models surpass the baselines in MathVista and GeoQA by 10.1% and 4.7%, outperforming advanced closed-source models like GPT-4o.

Chenlin Fu, Ao Gong, Yingying Zhu

Cross-View object geo-localization (CVOGL) aims to precisely determine the geographic coordinates of a query object from a ground or drone perspective by referencing a satellite map. Segmentation-based approaches offer high precision but require prohibitively expensive pixel-level annotations, whereas more economical detection-based methods suffer from lower accuracy. This performance disparity in detection is primarily caused by two factors: the poor geometric fit of Horizontal Bounding Boxes (HBoxes) for oriented objects and the degradation in precision due to feature map scaling. Motivated by these, we propose leveraging Rotated Bounding Boxes (RBoxes) as a natural extension of the detection-based paradigm. RBoxes provide a much tighter geometric fit to oriented objects. Building on this, we introduce OSGeo, a novel geo-localization framework, meticulously designed with a multi-scale perception module and an orientation-sensitive head to accurately regress RBoxes. To support this scheme, we also construct and release CVOGL-R, the first dataset with precise RBox annotations for CVOGL. Extensive experiments demonstrate that our OSGeo achieves state-of-the-art performance, consistently matching or even surpassing the accuracy of leading segmentation-based methods but with an annotation cost that is over an order of magnitude lower.

Mingkun Yang, Biao Yang, Minghui Liao et al.

Scene text recognition (STR) is a challenging task that requires large-scale annotated data for training. However, collecting and labeling real text images is expensive and time-consuming, which limits the availability of real data. Therefore, most existing STR methods resort to synthetic data, which may introduce domain discrepancy and degrade the performance of STR models. To alleviate this problem, recent semi-supervised STR methods exploit unlabeled real data by enforcing character-level consistency regularization between weakly and strongly augmented views of the same image. However, these methods neglect word-level consistency, which is crucial for sequence recognition tasks. This paper proposes a novel semi-supervised learning method for STR that incorporates word-level consistency regularization from both visual and semantic aspects. Specifically, we devise a shortest path alignment module to align the sequential visual features of different views and minimize their distance. Moreover, we adopt a reinforcement learning framework to optimize the semantic similarity of the predicted strings in the embedding space. We conduct extensive experiments on several standard and challenging STR benchmarks and demonstrate the superiority of our proposed method over existing semi-supervised STR methods.

Hongcheng Yang, Dingkang Liang, Dingyuan Zhang et al.

The recent advancements in point cloud learning have enabled intelligent vehicles and robots to comprehend 3D environments better. However, processing large-scale 3D scenes remains a challenging problem, such that efficient downsampling methods play a crucial role in point cloud learning. Existing downsampling methods either require a huge computational burden or sacrifice fine-grained geometric information. For such purpose, this paper presents an advanced sampler that achieves both high accuracy and efficiency. The proposed method utilizes voxel centroid sampling as a foundation but effectively addresses the challenges regarding voxel size determination and the preservation of critical geometric cues. Specifically, we propose a Voxel Adaptation Module that adaptively adjusts voxel sizes with the reference of point-based downsampling ratio. This ensures that the sampling results exhibit a favorable distribution for comprehending various 3D objects or scenes. Meanwhile, we introduce a network compatible with arbitrary voxel sizes for sampling and feature extraction while maintaining high efficiency. The proposed approach is demonstrated with 3D object detection and 3D semantic segmentation. Compared to existing state-of-the-art methods, our approach achieves better accuracy on outdoor and indoor large-scale datasets, e.g. Waymo and ScanNet, with promising efficiency.

Le Wu, Lv Bo, Songsong Ouyang et al.

Cross-view geo-localization (CVGL) aims to accurately localize street-view images through retrieval of corresponding geo-tagged satellite images. While prior works have achieved nearly perfect performance on certain standard datasets, their robustness in real-world corrupted environments remains under-explored. This oversight causes severe performance degradation or failure when images are affected by corruption such as blur or weather, significantly limiting practical deployment. To address this critical gap, we introduce MRGeo, the first systematic method designed for robust CVGL under corruption. MRGeo employs a hierarchical defense strategy that enhances the intrinsic quality of features and then enforces a robust geometric prior. Its core is the Spatial-Channel Enhancement Block, which contains: (1) a Spatial Adaptive Representation Module that models global and local features in parallel and uses a dynamic gating mechanism to arbitrate their fusion based on feature reliability; and (2) a Channel Calibration Module that performs compensatory adjustments by modeling multi-granularity channel dependencies to counteract information loss. To prevent spatial misalignment under severe corruption, a Region-level Geometric Alignment Module imposes a geometric structure on the final descriptors, ensuring coarse-grained consistency. Comprehensive experiments on both robustness benchmark and standard datasets demonstrate that MRGeo not only achieves an average R@1 improvement of 2.92\% across three comprehensive robustness benchmarks (CVUSA-C-ALL, CVACT\_val-C-ALL, and CVACT\_test-C-ALL) but also establishes superior performance in cross-area evaluation, thereby demonstrating its robustness and generalization capability.

Kunyu Zhang, Fukang Ge, Binyang Wang et al.

Unlike nature image classification where groundtruth label is explicit and of no doubt, physicians commonly interpret medical image conditioned on certainty like using phrase "probable" or "likely". Existing medical image datasets either simply overlooked the nuance and polarise into binary label. Here, we propose a novel framework that leverages a Large Language Model (LLM) to directly mine medical reports to utilise the uncertainty relevant expression for supervision signal. At first, we collect uncertainty keywords from medical reports. Then, we use Qwen-3 4B to identify the textual uncertainty and map them into an adaptive Generalized Label Smoothing (GLS) rate. This rate allows our model to treat uncertain labels not as errors, but as informative signals, effectively incorporating expert skepticism into the training process. We establish a new clinical expert uncertainty-aware benchmark to rigorously evaluate this problem. Experiments demonstrate that our approach significantly outperforms state-of-the-art methods in medical disease detection. The curated uncertainty words database, code, and benchmark will be made publicly available upon acceptance.

Yongxin Wang, Zhicheng Yang, Meng Cao et al.

Group-relative reinforcement learning with verifiable rewards (RLVR) often wastes the most informative data it already has the failures. When all rollouts are wrong, gradients stall; when one happens to be correct, the update usually ignores why the others are close-but-wrong, and credit can be misassigned to spurious chains. We present CARE (Contrastive Anchored REflection), a failure-centric post-training framework for multimodal reasoning that turns errors into supervision. CARE combines: (i) an anchored-contrastive objective that forms a compact subgroup around the best rollout and a set of semantically proximate hard negatives, performs within-subgroup z-score normalization with negative-only scaling, and includes an all-negative rescue to prevent zero-signal batches; and (ii) Reflection-Guided Resampling (RGR), a one-shot structured self-repair that rewrites a representative failure and re-scores it with the same verifier, converting near-misses into usable positives without any test-time reflection. CARE improves accuracy and training smoothness while explicitly increasing the share of learning signal that comes from failures. On Qwen2.5-VL-7B, CARE lifts macro-averaged accuracy by 4.6 points over GRPO across six verifiable visual-reasoning benchmarks; with Qwen3-VL-8B it reaches competitive or state-of-the-art results on MathVista and MMMU-Pro under an identical evaluation protocol.

Shuhan Hu, Yiru Li, Yuanyuan Li et al.

Cross-view object geo-localization enables high-precision object localization through cross-view matching, with critical applications in autonomous driving, urban management, and disaster response. However, existing methods rely on keypoint-based positional encoding, which captures only 2D coordinates while neglecting object shape information, resulting in sensitivity to annotation shifts and limited cross-view matching capability. To address these limitations, we propose a mask-based positional encoding scheme that leverages segmentation masks to capture both spatial coordinates and object silhouettes, thereby upgrading the model from "location-aware" to "object-aware." Furthermore, to tackle the challenge of large-span objects (e.g., elongated buildings) in satellite imagery, we design a context enhancement module. This module employs horizontal and vertical strip convolutional kernels to extract long-range contextual features, enhancing feature discrimination among strip-like objects. Integrating MPE and CEM, we present EDGeo, an end-to-end framework for robust cross-view object geo-localization. Extensive experiments on two public datasets (CVOGL and VIGOR-Building) demonstrate that our method achieves state-of-the-art performance, with a 3.39% improvement in localization accuracy under challenging ground-to-satellite scenarios. This work provides a robust positional encoding paradigm and a contextual modeling framework for advancing cross-view geo-localization research.

Yuqi Xiao, Yingying Zhu

Zero-shot Composed Image Retrieval (ZS-CIR) aims to retrieve a target image given a reference image and a relative text, without relying on costly triplet annotations. Existing CLIP-based methods face two core challenges: (1) union-based feature fusion indiscriminately aggregates all visual cues, carrying over irrelevant background details that dilute the intended modification, and (2) global cosine similarity from CLIP embeddings lacks the ability to resolve fine-grained semantic relations. To address these issues, we propose SETR (Semantic-enhanced Two-Stage Retrieval). In the coarse retrieval stage, SETR introduces an intersection-driven strategy that retains only the overlapping semantics between the reference image and relative text, thereby filtering out distractors inherent to union-based fusion and producing a cleaner, high-precision candidate set. In the fine-grained re-ranking stage, we adapt a pretrained multimodal LLM with Low-Rank Adaptation to conduct binary semantic relevance judgments ("Yes/No"), which goes beyond CLIP's global feature matching by explicitly verifying relational and attribute-level consistency. Together, these two stages form a complementary pipeline: coarse retrieval narrows the candidate pool with high recall, while re-ranking ensures precise alignment with nuanced textual modifications. Experiments on CIRR, Fashion-IQ, and CIRCO show that SETR achieves new state-of-the-art performance, improving Recall@1 on CIRR by up to 15.15 points. Our results establish two-stage reasoning as a general paradigm for robust and portable ZS-CIR.

Xingtao Ling, Chenlin Fu, Yingying Zhu

Most existing cross-view object geo-localization approaches adopt anchor-based paradigm. Although effective, such methods are inherently constrained by predefined anchors. To eliminate this dependency, we first propose an anchor-free formulation for cross-view object geo-localization, termed AFGeo. AFGeo directly predicts the four directional offsets (left, right, top, bottom) to the ground-truth box for each pixel, thereby localizing the object without any predefined anchors. To obtain a more robust spatial prior, AFGeo incorporates Gaussian Position Encoding (GPE) to model the click point in the query image, mitigating the uncertainty of object position that challenges object localization in cross-view scenarios. In addition, AFGeo incorporates a Cross-view Object Association Module (CVOAM) that relates the same object and its surrounding context across viewpoints, enabling reliable localization under large cross-view appearance gaps. By adopting an anchor-free localization paradigm that integrates GPE and CVOAM with minimal parameter overhead, our model is both lightweight and computationally efficient, achieving state-of-the-art performance on benchmark datasets.

Yun Liu, Jintu Huang, Yingying Zhu et al.

Peptide-drug conjugates (PDCs) represent a promising therapeutic avenue for human diseases, particularly in cancer treatment. Systematic elucidation of structure-activity relationships (SARs) and accurate prediction of the activity of PDCs are critical for the rational design and optimization of these conjugates. To this end, we carefully design and construct a benchmark PDCs dataset compiled from literature-derived collections and PDCdb database, and then develop PDCNet, the first unified deep learning framework for forecasting the activity of PDCs. The architecture systematically captures the complex factors underlying anticancer decisions of PDCs in real-word scenarios through a multi-level feature fusion framework that collaboratively characterizes and learns the features of peptides, linkers, and payloads. Leveraging a curated PDCs benchmark dataset, comprehensive evaluation results show that PDCNet demonstrates superior predictive capability, with the highest AUC, F1, MCC and BA scores of 0.9213, 0.7656, 0.7071 and 0.8388 for the test set, outperforming eight established traditional machine learning models. Multi-level validations, including 5-fold cross-validation, threshold testing, ablation studies, model interpretability analysis and external independent testing, further confirm the superiority, robustness, and usability of the PDCNet architecture. We anticipate that PDCNet represents a novel paradigm, incorporating both a benchmark dataset and advanced models, which can accelerate the design and discovery of new PDC-based therapeutic agents.

Zhibo Yang, Wei Hua, Sibo Song et al.

Visual Information Extraction (VIE), aiming at extracting structured information from visually rich document images, plays a pivotal role in document processing. Considering various layouts, semantic scopes, and languages, VIE encompasses an extensive range of types, potentially numbering in the thousands. However, many of these types suffer from a lack of training data, which poses significant challenges. In this paper, we propose a novel generative model, named Generative Compositor, to address the challenge of few-shot VIE. The Generative Compositor is a hybrid pointer-generator network that emulates the operations of a compositor by retrieving words from the source text and assembling them based on the provided prompts. Furthermore, three pre-training strategies are employed to enhance the model's perception of spatial context information. Besides, a prompt-aware resampler is specially designed to enable efficient matching by leveraging the entity-semantic prior contained in prompts. The introduction of the prompt-based retrieval mechanism and the pre-training strategies enable the model to acquire more effective spatial and semantic clues with limited training samples. Experiments demonstrate that the proposed method achieves highly competitive results in the full-sample training, while notably outperforms the baseline in the 1-shot, 5-shot, and 10-shot settings.

Haotian Ma, Lin Gu, Siyi Wu et al.

3D point cloud has been widely used in applications such as self-driving cars, robotics, CAD models, etc. To the best of our knowledge, these applications raised the issue of privacy leakage in 3D point clouds, which has not been studied well. Different from the 2D image privacy, which is related to texture and 2D geometric structure, the 3D point cloud is texture-less and only relevant to 3D geometric structure. In this work, we defined the 3D point cloud privacy problem and proposed an efficient privacy-preserving framework named PointFlowGMM that can support downstream classification and segmentation tasks without seeing the original data. Using a flow-based generative model, the point cloud is projected into a latent Gaussian mixture distributed subspace. We further designed a novel angular similarity loss to obfuscate the original geometric structure and reduce the model size from 767MB to 120MB without a decrease in recognition performance. The projected point cloud in the latent space is orthogonally rotated randomly to further protect the original geometric structure, the class-to-class relationship is preserved after rotation, thus, the protected point cloud can support the recognition task. We evaluated our model on multiple datasets and achieved comparable recognition results on encrypted point clouds compared to the original point clouds.

Hongji Yang, Yiru Li, Yingying Zhu

Information retrieval techniques have demonstrated exceptional capabilities in identifying semantic similarities across diverse domains through robust feature representations. However, their potential in guiding synthesis tasks, particularly cross-view image synthesis, remains underexplored. Cross-view image synthesis presents significant challenges in establishing reliable correspondences between drastically different viewpoints. To address this, we propose a novel retrieval-guided framework that reimagines how retrieval techniques can facilitate effective cross-view image synthesis. Unlike existing methods that rely on auxiliary information, such as semantic segmentation maps or preprocessing modules, our retrieval-guided framework captures semantic similarities across different viewpoints, trained through contrastive learning to create a smooth embedding space. Furthermore, a novel fusion mechanism leverages these embeddings to guide image synthesis while learning and encoding both view-invariant and view-specific features. To further advance this area, we introduce VIGOR-GEN, a new urban-focused dataset with complex viewpoint variations in real-world scenarios. Extensive experiments demonstrate that our retrieval-guided approach significantly outperforms existing methods on the CVUSA, CVACT and VIGOR-GEN datasets, particularly in retrieval accuracy (R@1) and synthesis quality (FID). Our work bridges information retrieval and synthesis tasks, offering insights into how retrieval techniques can address complex cross-domain synthesis challenges.

Xudong Xie, Zhen Zhu, Zijie Wu et al.

This paper aims for a new generation task: non-stationary multi-texture synthesis, which unifies synthesizing multiple non-stationary textures in a single model. Most non-stationary textures have large scale variance and can hardly be synthesized through one model. To combat this, we propose a multi-scale generator to capture structural patterns of various scales and effectively synthesize textures with a minor cost. However, it is still hard to handle textures of different categories with different texture patterns. Therefore, we present a category-specific training strategy to focus on learning texture pattern of a specific domain. Interestingly, once trained, our model is able to produce multi-pattern generations with dynamic variations without the need to finetune the model for different styles. Moreover, an objective evaluation metric is designed for evaluating the quality of texture expansion and global structure consistency. To our knowledge, ours is the first scheme for this challenging task, including model, training, and evaluation. Experimental results demonstrate the proposed method achieves superior performance and time efficiency. The code will be available after the publication.

Qiyuan An, Ruijiang Li, Lin Gu et al.

Unsupervised domain adaptation (UDA) generally aligns the unlabeled target domain data to the distribution of the source domain to mitigate the distribution shift problem. The standard UDA requires sharing the source data with the target, having potential data privacy leaking risks. To protect the source data's privacy, we first propose to share the source feature distribution instead of the source data. However, sharing only the source feature distribution may still suffer from the membership inference attack who can infer an individual's membership by the black-box access to the source model. To resolve this privacy issue, we further study the under-explored problem of privacy-preserving domain adaptation and propose a method with a novel differential privacy training strategy to protect the source data privacy. We model the source feature distribution by Gaussian Mixture Models (GMMs) under the differential privacy setting and send it to the target client for adaptation. The target client resamples differentially private source features from GMMs and adapts on target data with several state-of-art UDA backbones. With our proposed method, the source data provider could avoid leaking source data privacy during domain adaptation as well as reserve the utility. To evaluate our proposed method's utility and privacy loss, we apply our model on a medical report disease label classification task using two noisy challenging clinical text datasets. The results show that our proposed method can preserve source data's privacy with a minor performance influence on the text classification task.

Ziteng Cui, Yingying Zhu, Lin Gu et al.

Image restoration algorithms such as super resolution (SR) are indispensable pre-processing modules for object detection in degraded images. However, most of these algorithms assume the degradation is fixed and known a priori. When the real degradation is unknown or differs from assumption, both the pre-processing module and the consequent high-level task such as object detection would fail. Here, we propose a novel framework, RestoreDet, to detect objects in degraded low resolution images. RestoreDet utilizes the downsampling degradation as a kind of transformation for self-supervised signals to explore the equivariant representation against various resolutions and other degradation conditions. Specifically, we learn this intrinsic visual structure by encoding and decoding the degradation transformation from a pair of original and randomly degraded images. The framework could further take the advantage of advanced SR architectures with an arbitrary resolution restoring decoder to reconstruct the original correspondence from the degraded input image. Both the representation learning and object detection are optimized jointly in an end-to-end training fashion. RestoreDet is a generic framework that could be implemented on any mainstream object detection architectures. The extensive experiment shows that our framework based on CenterNet has achieved superior performance compared with existing methods when facing variant degradation situations. Our code would be released soon.

Yifei Huang, Xiaoxiao Li, Lijin Yang et al.

The human gaze is a cost-efficient physiological data that reveals human underlying attentional patterns. The selective attention mechanism helps the cognition system focus on task-relevant visual clues by ignoring the presence of distractors. Thanks to this ability, human beings can efficiently learn from a very limited number of training samples. Inspired by this mechanism, we aim to leverage gaze for medical image analysis tasks with small training data. Our proposed framework includes a backbone encoder and a Selective Attention Network (SAN) that simulates the underlying attention. The SAN implicitly encodes information such as suspicious regions that is relevant to the medical diagnose tasks by estimating the actual human gaze. Then we design a novel Auxiliary Attention Block (AAB) to allow information from SAN to be utilized by the backbone encoder to focus on selective areas. Specifically, this block uses a modified version of a multi-head attention layer to simulate the human visual search procedure. Note that the SAN and AAB can be plugged into different backbones, and the framework can be used for multiple medical image analysis tasks when equipped with task-specific heads. Our method is demonstrated to achieve superior performance on both 3D tumor segmentation and 2D chest X-ray classification tasks. We also show that the estimated gaze probability map of the SAN is consistent with an actual gaze fixation map obtained by board-certified doctors.

Xinwei He, Silin Cheng, Dingkang Liang et al.

Recently, 3D shape understanding has achieved significant progress due to the advances of deep learning models on various data formats like images, voxels, and point clouds. Among them, point clouds and multi-view images are two complementary modalities of 3D objects and learning representations by fusing both of them has been proven to be fairly effective. While prior works typically focus on exploiting global features of the two modalities, herein we argue that more discriminative features can be derived by modeling ``where to fuse''. To investigate this, we propose a novel Locality-Aware Point-View Fusion Transformer (LATFormer) for 3D shape retrieval and classification. The core component of LATFormer is a module named Locality-Aware Fusion (LAF) which integrates the local features of correlated regions across the two modalities based on the co-occurrence scores. We further propose to filter out scores with low values to obtain salient local co-occurring regions, which reduces redundancy for the fusion process. In our LATFormer, we utilize the LAF module to fuse the multi-scale features of the two modalities both bidirectionally and hierarchically to obtain more informative features. Comprehensive experiments on four popular 3D shape benchmarks covering 3D object retrieval and classification validate its effectiveness.

Hoang T. N. Nguyen, Dong Nie, Taivanbat Badamdorj et al.

Our paper focuses on automating the generation of medical reports from chest X-ray image inputs, a critical yet time-consuming task for radiologists. Unlike existing medical re-port generation efforts that tend to produce human-readable reports, we aim to generate medical reports that are both fluent and clinically accurate. This is achieved by our fully differentiable and end-to-end paradigm containing three complementary modules: taking the chest X-ray images and clinical his-tory document of patients as inputs, our classification module produces an internal check-list of disease-related topics, referred to as enriched disease embedding; the embedding representation is then passed to our transformer-based generator, giving rise to the medical reports; meanwhile, our generator also pro-duces the weighted embedding representation, which is fed to our interpreter to ensure consistency with respect to disease-related topics.Our approach achieved promising results on commonly-used metrics concerning language fluency and clinical accuracy. Moreover, noticeable performance gains are consistently ob-served when additional input information is available, such as the clinical document and extra scans of different views.

Hongji Yang, Xiufan Lu, Yingying Zhu

In this work, we address the problem of cross-view geo-localization, which estimates the geospatial location of a street view image by matching it with a database of geo-tagged aerial images. The cross-view matching task is extremely challenging due to drastic appearance and geometry differences across views. Unlike existing methods that predominantly fall back on CNN, here we devise a novel evolving geo-localization Transformer (EgoTR) that utilizes the properties of self-attention in Transformer to model global dependencies, thus significantly decreasing visual ambiguities in cross-view geo-localization. We also exploit the positional encoding of Transformer to help the EgoTR understand and correspond geometric configurations between ground and aerial images. Compared to state-of-the-art methods that impose strong assumption on geometry knowledge, the EgoTR flexibly learns the positional embeddings through the training objective and hence becomes more practical in many real-world scenarios. Although Transformer is well suited to our task, its vanilla self-attention mechanism independently interacts within image patches in each layer, which overlooks correlations between layers. Instead, this paper propose a simple yet effective self-cross attention mechanism to improve the quality of learned representations. The self-cross attention models global dependencies between adjacent layers, which relates between image patches while modeling how features evolve in the previous layer. As a result, the proposed self-cross attention leads to more stable training, improves the generalization ability and encourages representations to keep evolving as the network goes deeper. Extensive experiments demonstrate that our EgoTR performs favorably against state-of-the-art methods on standard, fine-grained and cross-dataset cross-view geo-localization tasks.

Qingyu Chen, Tiarnan D. L. Keenan, Alexis Allot et al.

Objective Reticular pseudodrusen (RPD), a key feature of age-related macular degeneration (AMD), are poorly detected by human experts on standard color fundus photography (CFP) and typically require advanced imaging modalities such as fundus autofluorescence (FAF). The objective was to develop and evaluate the performance of a novel 'M3' deep learning framework on RPD detection. Materials and Methods A deep learning framework M3 was developed to detect RPD presence accurately using CFP alone, FAF alone, or both, employing >8000 CFP-FAF image pairs obtained prospectively (Age-Related Eye Disease Study 2). The M3 framework includes multi-modal (detection from single or multiple image modalities), multi-task (training different tasks simultaneously to improve generalizability), and multi-attention (improving ensembled feature representation) operation. Performance on RPD detection was compared with state-of-the-art deep learning models and 13 ophthalmologists; performance on detection of two other AMD features (geographic atrophy and pigmentary abnormalities) was also evaluated. Results For RPD detection, M3 achieved area under receiver operating characteristic (AUROC) 0.832, 0.931, and 0.933 for CFP alone, FAF alone, and both, respectively. M3 performance on CFP was very substantially superior to human retinal specialists (median F1-score 0.644 versus 0.350). External validation (on Rotterdam Study, Netherlands) demonstrated high accuracy on CFP alone (AUROC 0.965). The M3 framework also accurately detected geographic atrophy and pigmentary abnormalities (AUROC 0.909 and 0.912, respectively), demonstrating its generalizability. Conclusion This study demonstrates the successful development, robust evaluation, and external validation of a novel deep learning framework that enables accessible, accurate, and automated AMD diagnosis and prognosis.

Youbao Tang, Yuxing Tang, Yingying Zhu et al.

Developing an effective liver and liver tumor segmentation model from CT scans is very important for the success of liver cancer diagnosis, surgical planning and cancer treatment. In this work, we propose a two-stage framework for 2D liver and tumor segmentation. The first stage is a coarse liver segmentation network, while the second stage is an edge enhanced network (E$^2$Net) for more accurate liver and tumor segmentation. E$^2$Net explicitly models complementary objects (liver and tumor) and their edge information within the network to preserve the organ and lesion boundaries. We introduce an edge prediction module in E$^2$Net and design an edge distance map between liver and tumor boundaries, which is used as an extra supervision signal to train the edge enhanced network. We also propose a deep cross feature fusion module to refine multi-scale features from both objects and their edges. E$^2$Net is more easily and efficiently trained with a small labeled dataset, and it can be trained/tested on the original 2D CT slices (resolve resampling error issue in 3D models). The proposed framework has shown superior performance on both liver and liver tumor segmentation compared to several state-of-the-art 2D, 3D and 2D/3D hybrid frameworks.

Yingying Zhu, Youbao Tang, Yuxing Tang et al.

Current deep learning based segmentation models often generalize poorly between domains due to insufficient training data. In real-world clinical applications, cross-domain image analysis tools are in high demand since medical images from different domains are often needed to achieve a precise diagnosis. An important example in radiology is generalizing from non-contrast CT to contrast enhanced CTs. Contrast enhanced CT scans at different phases are used to enhance certain pathologies or organs. Many existing cross-domain image-to-image translation models have been shown to improve cross-domain segmentation of large organs. However, such models lack the ability to preserve fine structures during the translation process, which is significant for many clinical applications, such as segmenting small calcified plaques in the aorta and pelvic arteries. In order to preserve fine structures during medical image translation, we propose a patch-based model using shared latent variables from a Gaussian mixture model. We compare our image translation framework to several state-of-the-art methods on cross-domain image translation and show our model does a better job preserving fine structures. The superior performance of our model is verified by performing two tasks with the translated images - detection and segmentation of aortic plaques and pancreas segmentation. We expect the utility of our framework will extend to other problems beyond segmentation due to the improved quality of the generated images and enhanced ability to preserve small structures.

Yingying Zhu, Daniel C. Elton, Sungwon Lee et al.

Calcified plaque in the aorta and pelvic arteries is associated with coronary artery calcification and is a strong predictor of heart attack. Current calcified plaque detection models show poor generalizability to different domains (ie. pre-contrast vs. post-contrast CT scans). Many recent works have shown how cross domain object detection can be improved using an image translation model which translates between domains using a single shared latent space. However, while current image translation models do a good job preserving global/intermediate level structures they often have trouble preserving tiny structures. In medical imaging applications, preserving small structures is important since these structures can carry information which is highly relevant for disease diagnosis. Recent works on image reconstruction show that complex real-world images are better reconstructed using a union of subspaces approach. Since small image patches are used to train the image translation model, it makes sense to enforce that each patch be represented by a linear combination of subspaces which may correspond to the different parts of the body present in that patch. Motivated by this, we propose an image translation network using a shared union of subspaces constraint and show our approach preserves subtle structures (plaques) better than the conventional method. We further applied our method to a cross domain plaque detection task and show significant improvement compared to the state-of-the art method.

Bin Sun, Chen Chen, Yingying Zhu et al.

The task of cross-view image geo-localization aims to determine the geo-location (GPS coordinates) of a query ground-view image by matching it with the GPS-tagged aerial (satellite) images in a reference dataset. Due to the dramatic changes of viewpoint, matching the cross-view images is challenging. In this paper, we propose the GeoCapsNet based on the capsule network for ground-to-aerial image geo-localization. The network first extracts features from both ground-view and aerial images via standard convolution layers and the capsule layers further encode the features to model the spatial feature hierarchies and enhance the representation power. Moreover, we introduce a simple and effective weighted soft-margin triplet loss with online batch hard sample mining, which can greatly improve image retrieval accuracy. Experimental results show that our GeoCapsNet significantly outperforms the state-of-the-art approaches on two benchmark datasets.

Yingying Zhu, Jiong Wang, Lingxi Xie et al.

Visual place recognition is challenging in the urban environment and is usually viewed as a large scale image retrieval task. The intrinsic challenges in place recognition exist that the confusing objects such as cars and trees frequently occur in the complex urban scene, and buildings with repetitive structures may cause over-counting and the burstiness problem degrading the image representations. To address these problems, we present an Attention-based Pyramid Aggregation Network (APANet), which is trained in an end-to-end manner for place recognition. One main component of APANet, the spatial pyramid pooling, can effectively encode the multi-size buildings containing geo-information. The other one, the attention block, is adopted as a region evaluator for suppressing the confusing regional features while highlighting the discriminative ones. When testing, we further propose a simple yet effective PCA power whitening strategy, which significantly improves the widely used PCA whitening by reasonably limiting the impact of over-counting. Experimental evaluations demonstrate that the proposed APANet outperforms the state-of-the-art methods on two place recognition benchmarks, and generalizes well on standard image retrieval datasets.

Yingying Zhu, Mert R. Sabuncu

In this work, we consider the problem of predicting the course of a progressive disease, such as cancer or Alzheimer's. Progressive diseases often start with mild symptoms that might precede a diagnosis, and each patient follows their own trajectory. Patient trajectories exhibit wild variability, which can be associated with many factors such as genotype, age, or sex. An additional layer of complexity is that, in real life, the amount and type of data available for each patient can differ significantly. For example, for one patient we might have no prior history, whereas for another patient we might have detailed clinical assessments obtained at multiple prior time-points. This paper presents a probabilistic model that can handle multiple modalities (including images and clinical assessments) and variable patient histories with irregular timings and missing entries, to predict clinical scores at future time-points. We use a sigmoidal function to model latent disease progression, which gives rise to clinical observations in our generative model. We implemented an approximate Bayesian inference strategy on the proposed model to estimate the parameters on data from a large population of subjects. Furthermore, the Bayesian framework enables the model to automatically fine-tune its predictions based on historical observations that might be available on the test subject. We applied our method to a longitudinal Alzheimer's disease dataset with more than 3000 subjects [23] and present a detailed empirical analysis of prediction performance under different scenarios, with comparisons against several benchmarks. We also demonstrate how the proposed model can be interrogated to glean insights about temporal dynamics in Alzheimer's disease.