Xinyi Tang

Eason Chen, Chenyu Lin, Xinyi Tang et al. · cmu

The rapid evolution of large language models (LLMs) has transformed human-computer interaction (HCI), but the interaction with LLMs is currently mainly focused on text-based interactions, while other multi-model approaches remain under-explored. This paper introduces VTutor, an open-source Software Development Kit (SDK) that combines generative AI with advanced animation technologies to create engaging, adaptable, and realistic APAs for human-AI multi-media interactions. VTutor leverages LLMs for real-time personalized feedback, advanced lip synchronization for natural speech alignment, and WebGL rendering for seamless web integration. Supporting various 2D and 3D character models, VTutor enables researchers and developers to design emotionally resonant, contextually adaptive learning agents. This toolkit enhances learner engagement, feedback receptivity, and human-AI interaction while promoting trustworthy AI principles in education. VTutor sets a new standard for next-generation APAs, offering an accessible, scalable solution for fostering meaningful and immersive human-AI interaction experiences. The VTutor project is open-sourced and welcomes community-driven contributions and showcases.

Eason Chen, Isabel Wang, Nina Yuan et al.

Behavioral analysis of tutoring dialogues is essential for understanding student learning, yet manual coding remains a bottleneck. We present a methodology where LLM coding agents autonomously improve the prompts used by LLM classifiers to label educational dialogues. In each iteration, a coding agent runs the classifier against human-labeled validation data, analyzes disagreements, and proposes theory-grounded prompt modifications for researcher review. Applying this approach to 659 AI tutoring sessions across four experiments with three agents and three classifiers, 4-fold cross-validation on held-out data confirmed genuine improvement: the best agent achieved test $κ=0.78$ (SD$=0.08$), matching human inter-rater reliability ($κ=0.78$), at a cost of approximately \$5--8 per agent. While development-set performance reached $κ=0.91$--$0.93$, the cross-validated results represent our primary generalization claim. The iterative process also surfaced an undocumented labeling pattern: human coders consistently treated expressions of confusion as engagement rather than disengagement. Continued iteration beyond the optimum led to regression, underscoring the need for held-out validation. We release all prompts, iteration logs, and data.

Jiebin Fang, Zidi Yan, Churu Mao et al.

Nuclear magnetic resonance (NMR) spectroscopy provides an experimental readout of local chemical environments, but its use in molecular representation learning has been constrained by heterogeneous data and incomplete atom-level assignments. Here we construct complementary high-fidelity experimental and computational 13C NMR resources, which reveal a recurrent form of representational collapse: atoms that are equivalent in molecular topology can remain experimentally distinct in their real chemical environments, whereas explicit 3D descriptions are further limited by static conformations in dynamic regimes. To alleviate this bottleneck, we develop CLAIM (Contrastive Learning for Atom-to-molecule Inference of Molecular NMR), a framework that aligns efficient topological molecular inputs with atom-resolved NMR observables. Through hierarchical chemical priors and cross-level contrastive learning, CLAIM restores lost chemical resolution and markedly improves atom-level molecule-spectrum retrieval. CLAIM remains robust in flexible and tautomeric systems for 13C NMR prediction, improves stereoisomer discrimination without explicit 3D modelling, and transfers to broader molecular property tasks including ADMET prediction and fluorescence estimation. These results establish physically grounded spectral alignment as an effective strategy for alleviating chemical-environment collapse and for guiding experimentally grounded molecular representation learning.

Vanshika Vats, Marzia Binta Nizam, Minghao Liu et al.

As the capabilities of artificial intelligence (AI) continue to expand rapidly, Human-AI (HAI) Collaboration, combining human intellect and AI systems, has become pivotal for advancing problem-solving and decision-making processes. The advent of Large Foundation Models (LFMs) has greatly expanded its potential, offering unprecedented capabilities by leveraging vast amounts of data to understand and predict complex patterns. At the same time, realizing this potential responsibly requires addressing persistent challenges related to safety, fairness, and control. This paper reviews the crucial integration of LFMs with HAI, highlighting both opportunities and risks. We structure our analysis around four areas: human-guided model development, collaborative design principles, ethical and governance frameworks, and applications in high-stakes domains. Our review shows that successful HAI systems are not the automatic result of stronger models but the product of careful, human-centered design. By identifying key open challenges, this survey aims to give insight into current and future research that turns the raw power of LFMs into partnerships that are reliable, trustworthy, and beneficial to society.

Eason Chen, Xinyi Tang, Yvonne Zhao et al.

We conducted a between-subjects experiment (N=92) comparing three conditions in a calculus learning environment: no self-explanation (control), menu-based self-explanation, and open-ended self-explanation with LLM-generated feedback. All conditions showed positive learning gains within a fixed 60-minute practice session, with no significant between-condition differences in post-test performance. On transfer questions, the open-ended condition produced significantly higher-quality explanations than control on "Not Enough Information" (NEI) problems ($β$=+11.9 percentage points, $p$=.030), though the corresponding NEI multiple-choice accuracy advantage was not significant ($p$=.183). Moreover, across all post-test open-ended explanations, the open-ended condition showed a marginally significant advantage ($β$=+7.3%, $p$=.057). These findings suggest that LLM-supported open-ended self-explanation can improve explanation quality on NEI transfer problems, with weaker evidence across broader transfer explanation measures. Notably, these effects emerged even though learners in the open-ended condition completed substantially fewer practice problems within the same practice time.

Eason Chen, Sophia Judicke, Kayla Beigh et al.

We evaluate GPTutor, an LLM-powered tutoring system for an undergraduate discrete mathematics course. It integrates two LLM-supported tools: a structured proof-review tool that provides embedded feedback on students' written proof attempts, and a chatbot for math questions. In a staggered-access study with 148 students, earlier access was associated with higher homework performance during the interval when only the experimental group could use the system, while we did not observe this performance increase transfer to exam scores. Usage logs show that students with lower self-efficacy and prior exam performance used both components more frequently. Session-level behavioral labels, produced by human coding and scaled using an automated classifier, characterize how students engaged with the chatbot (e.g., answer-seeking or help-seeking). In models controlling for prior performance and self-efficacy, higher chatbot usage and answer-seeking behavior were negatively associated with subsequent midterm performance, whereas proof-review usage showed no detectable independent association. Together, the findings suggest that chatbot-based support alone may not reliably support transfer to independent assessment of math proof-learning outcomes, whereas work-anchored, structured feedback appears less associated with reduced learning.