Haoran Xu

Yi Fang, Haoran Xu, Jiaxin Han et al.

Foundation models have revolutionized various fields such as natural language processing (NLP) and computer vision (CV). While efforts have been made to transfer the success of the foundation models in general AI domains to biology, existing works focus on directly adopting the existing foundation model architectures from general machine learning domains without a systematic design considering the unique physicochemical and structural properties of each biological data modality. This leads to suboptimal performance, as these repurposed architectures struggle to capture the long-range dependencies, sparse information, and complex underlying ``grammars'' inherent to biological data. To address this gap, we introduce BioArc, a novel framework designed to move beyond intuition-driven architecture design towards principled, automated architecture discovery for biological foundation models. Leveraging Neural Architecture Search (NAS), BioArc systematically explores a vast architecture design space, evaluating architectures across multiple biological modalities while rigorously analyzing the interplay between architecture, tokenization, and training strategies. This large-scale analysis identifies novel, high-performance architectures, allowing us to distill a set of empirical design principles to guide future model development. Furthermore, to make the best of this set of discovered principled architectures, we propose and compare several architecture prediction methods that effectively and efficiently predict optimal architectures for new biological tasks. Overall, our work provides a foundational resource and a principled methodology to guide the creation of the next generation of task-specific and foundation models for biology.

Weitao Wang, Haoran Xu, Yuxiao Yang et al.

Recent years have witnessed remarkable progress in 3D content generation. However, corresponding evaluation methods struggle to keep pace. Automatic approaches have proven challenging to align with human preferences, and the mixed comparison of text- and image-driven methods often leads to unfair evaluations. In this paper, we present a comprehensive framework to better align and evaluate multi-view diffusion models with human preferences. To begin with, we first collect and filter a standardized image prompt set from DALL$\cdot$E and Objaverse, which we then use to generate multi-view assets with several multi-view diffusion models. Through a systematic ranking pipeline on these assets, we obtain a human annotation dataset with 16k expert pairwise comparisons and train a reward model, coined MVReward, to effectively encode human preferences. With MVReward, image-driven 3D methods can be evaluated against each other in a more fair and transparent manner. Building on this, we further propose Multi-View Preference Learning (MVP), a plug-and-play multi-view diffusion tuning strategy. Extensive experiments demonstrate that MVReward can serve as a reliable metric and MVP consistently enhances the alignment of multi-view diffusion models with human preferences.

Weitao Wang, Haoran Xu, Jun Meng et al.

As 3D generation techniques continue to flourish, the demand for generating personalized content is rapidly rising. Users increasingly seek to apply various editing methods to polish generated 3D content, aiming to enhance its color, style, and lighting without compromising the underlying geometry. However, most existing editing tools focus on the 2D domain, and directly feeding their results into 3D generation methods (like multi-view diffusion models) will introduce information loss, degrading the quality of the final 3D assets. In this paper, we propose a tuning-free, plug-and-play scheme that aligns edited assets with their original geometry in a single inference run. Central to our approach is a geometry preservation module that guides the edited multi-view generation with original input normal latents. Besides, an injection switcher is proposed to deliberately control the supervision extent of the original normals, ensuring the alignment between the edited color and normal views. Extensive experiments show that our method consistently improves both the multi-view consistency and mesh quality of edited 3D assets, across multiple combinations of multi-view diffusion models and editing methods.