Min Cen

Kongcheng Zhang, Qi Yao, Shunyu Liu et al.

Reinforcement Learning (RL) has shown promise for aligning Large Language Models (LLMs) to follow instructions with various constraints. Despite the encouraging results, RL improvement inevitably relies on sampling successful, high-quality responses; however, the initial model often struggles to generate responses that satisfy all constraints due to its limited capabilities, yielding sparse or indistinguishable rewards that impede learning. In this work, we propose Hindsight instruction Replay (HiR), a novel sample-efficient RL framework for complex instruction following tasks, which employs a select-then-rewrite strategy to replay failed attempts as successes based on the constraints that have been satisfied in hindsight. We perform RL on these replayed samples as well as the original ones, theoretically framing the objective as dual-preference learning at both the instruction- and response-level to enable efficient optimization using only a binary reward signal. Extensive experiments demonstrate that the proposed HiR yields promising results across different instruction following tasks, while requiring less computational budget. Our code and dataset is available at https://github.com/sastpg/HIR.

Cheng Tang, Junzhi Ning, Min Cen et al.

Reinforcement learning with verifiable rewards (RLVR) drives multimodal reasoning, but answer-level correctness does not guarantee that a vision-language model grounds its predictions in visual evidence. Existing visual-intervention methods contrast policy behavior on original and modified images, yet assign supervision by the type of intervention rather than its observed effect. This assumption fails: identical operators produce heterogeneous outcomes across samples. We propose SIVA-RL, a Sensitivity-Invariance Visual Alignment framework that replaces operator-conditioned regularization with sample-wise, outcome-conditioned supervision. SIVA-RL constructs localized interventions through token-aligned, distance-constrained within-image PatchSwap. A frozen audit policy then scores each clean-intervention pair, and the observed reward drop becomes soft routing weights. Large-drop pairs drive sensitivity alignment, low-drop pairs drive clean-anchored invariance alignment, and ambiguous pairs are down-weighted. This design decouples intervention construction from supervision assignment and is compatible with both GRPO and DAPO backbones. Across nine multimodal reasoning benchmarks spanning mathematical, logical, and vision-dependent tasks, SIVA-RL improves 3B and 7B models over matched RL baselines in every setting. It yields an 8.79 percentage-point gain on vision-dependent reasoning and up to 14.9% relative overall improvement across all four GRPO- and DAPO-based configurations.

Zheng Wang, Hong Liu, Zheng Wang et al.

Survival analysis based on Whole Slide Images (WSIs) is crucial for evaluating cancer prognosis, as they offer detailed microscopic information essential for predicting patient outcomes. However, traditional WSI-based survival analysis usually faces noisy features and limited data accessibility, hindering their ability to capture critical prognostic features effectively. Although pathology reports provide rich patient-specific information that could assist analysis, their potential to enhance WSI-based survival analysis remains largely unexplored. To this end, this paper proposes a novel Report-auxiliary self-distillation (Rasa) framework for WSI-based survival analysis. First, advanced large language models (LLMs) are utilized to extract fine-grained, WSI-relevant textual descriptions from original noisy pathology reports via a carefully designed task prompt. Next, a self-distillation-based pipeline is designed to filter out irrelevant or redundant WSI features for the student model under the guidance of the teacher model's textual knowledge. Finally, a risk-aware mix-up strategy is incorporated during the training of the student model to enhance both the quantity and diversity of the training data. Extensive experiments carried out on our collected data (CRC) and public data (TCGA-BRCA) demonstrate the superior effectiveness of Rasa against state-of-the-art methods. Our code is available at https://github.com/zhengwang9/Rasa.

Zhenfeng Zhuang, Min Cen, Yanfeng Li et al.

Significant disparities between the features of natural images and those inherent to histopathological images make it challenging to directly apply and transfer pre-trained models from natural images to histopathology tasks. Moreover, the frequent lack of annotations in histopathology patch images has driven researchers to explore self-supervised learning methods like mask reconstruction for learning representations from large amounts of unlabeled data. Crucially, previous mask-based efforts in self-supervised learning have often overlooked the spatial interactions among entities, which are essential for constructing accurate representations of pathological entities. To address these challenges, constructing graphs of entities is a promising approach. In addition, the diffusion reconstruction strategy has recently shown superior performance through its random intensity noise addition technique to enhance the robust learned representation. Therefore, we introduce H-MGDM, a novel self-supervised Histopathology image representation learning method through the Dynamic Entity-Masked Graph Diffusion Model. Specifically, we propose to use complementary subgraphs as latent diffusion conditions and self-supervised targets respectively during pre-training. We note that the graph can embed entities' topological relationships and enhance representation. Dynamic conditions and targets can improve pathological fine reconstruction. Our model has conducted pretraining experiments on three large histopathological datasets. The advanced predictive performance and interpretability of H-MGDM are clearly evaluated on comprehensive downstream tasks such as classification and survival analysis on six datasets. Our code will be publicly available at https://github.com/centurion-crawler/H-MGDM.