Nitish V. Thakor

Avisha Kumar, Kunal Kotkar, Kelly Jiang et al.

While deep learning has catalyzed breakthroughs across numerous domains, its broader adoption in clinical settings is inhibited by the costly and time-intensive nature of data acquisition and annotation. To further facilitate medical machine learning, we present an ultrasound dataset of 10,223 Brightness-mode (B-mode) images consisting of sagittal slices of porcine spinal cords (N=25) before and after a contusion injury. We additionally benchmark the performance metrics of several state-of-the-art object detection algorithms to localize the site of injury and semantic segmentation models to label the anatomy for comparison and creation of task-specific architectures. Finally, we evaluate the zero-shot generalization capabilities of the segmentation models on human ultrasound spinal cord images to determine whether training on our porcine dataset is sufficient for accurately interpreting human data. Our results show that the YOLOv8 detection model outperforms all evaluated models for injury localization, achieving a mean Average Precision (mAP50-95) score of 0.606. Segmentation metrics indicate that the DeepLabv3 segmentation model achieves the highest accuracy on unseen porcine anatomy, with a Mean Dice score of 0.587, while SAMed achieves the highest Mean Dice score generalizing to human anatomy (0.445). To the best of our knowledge, this is the largest annotated dataset of spinal cord ultrasound images made publicly available to researchers and medical professionals, as well as the first public report of object detection and segmentation architectures to assess anatomical markers in the spinal cord for methodology development and clinical applications.

Ruichen Yang, György M. Lévay, Christopher L. Hunt et al.

State-of-the-art upper limb myoelectric prostheses often use pattern recognition (PR) control systems that translate electromyography (EMG) signals into desired movements. As prosthesis movement complexity increases, users often struggle to produce sufficiently distinct EMG patterns for reliable classification. Existing training typically involves heuristic, trial-and-error user adjustments to static decoder boundaries. Goal: We introduce the Reviewer, a 3D visual interface projecting EMG signals directly into the decoder's classification space, providing intuitive, real-time insight into PR algorithm behavior. This structured feedback reduces cognitive load and fosters mutual, data-driven adaptation between user-generated EMG patterns and decoder boundaries. Methods: A 10-session study with 12 able-bodied participants compared PR performance after motor-based training and updating using the Reviewer versus conventional virtual arm visualization. Performance was assessed using a Fitts law task that involved the aperture of the cursor and the control of orientation. Results: Participants trained with the Reviewer achieved higher completion rates, reduced overshoot, and improved path efficiency and throughput compared to the standard visualization group. Significance: The Reviewer introduces decoder-informed motor training, facilitating immediate and consistent PR-based myoelectric control improvements. By iteratively refining control through real-time feedback, this approach reduces reliance on trial-and-error recalibration, enabling a more adaptive, self-correcting training framework. Conclusion: The 3D visual feedback significantly improves PR control in novice operators through structured training, enabling feedback-driven adaptation and reducing reliance on extensive heuristic adjustments.

Joseph L. Betthauser, Rebecca Greene, Ananya Dhawan et al.

One of the most elusive goals in myographic prosthesis control is the ability to reliably decode continuous positions simultaneously across multiple degrees-of-freedom. Goal: To demonstrate dexterous, natural, biomimetic finger and wrist control of the highly advanced robotic Modular Prosthetic Limb. Methods: We combine sequential temporal regression models and reinforcement learning using myographic signals to predict continuous simultaneous predictions of 7 finger and wrist degrees-of-freedom for 9 non-amputee human subjects in a minimally-constrained freeform training process. Results: We demonstrate highly dexterous 7 DoF position-based regression for prosthesis control from EMG signals, with significantly lower error rates than traditional approaches (p < 0.001) and nearly zero prediction response time delay (p < 0.001). Their performance can be continuously improved at any time using our freeform reinforcement process. Significance: We have demonstrated the most dexterous, biomimetic, and natural prosthesis control performance ever obtained from the surface EMG signal. Our reinforcement approach allowed us to abandon standard training protocols and simply allow the subject to move in any desired way while our models adapt. Conclusions: This work redefines the state-of-the-art in myographic decoding in terms of the reliability, responsiveness, and movement complexity available from prosthesis control systems. The present-day emergence and convergence of advanced algorithmic methods, experiment protocols, dexterous robotic prostheses, and sensor modalities represents a unique opportunity to finally realize our ultimate goal of achieving fully restorative natural upper-limb function for amputees.

Xianliang Ge, Yunxian Pan, Sujie Wang et al.

Intention decoding is an indispensable procedure in hands-free human-computer interaction (HCI). Conventional eye-tracking system using single-model fixation duration possibly issues commands ignoring users' real expectation. In the current study, an eye-brain hybrid brain-computer interface (BCI) interaction system was introduced for intention detection through fusion of multi-modal eye-track and ERP (a measurement derived from EEG) features. Eye-track and EEG data were recorded from 64 healthy participants as they performed a 40-min customized free search task of a fixed target icon among 25 icons. The corresponding fixation duration of eye-tracking and ERP were extracted. Five previously-validated LDA-based classifiers (including RLDA, SWLDA, BLDA, SKLDA, and STDA) and the widely-used CNN method were adopted to verify the efficacy of feature fusion from both offline and pseudo-online analysis, and optimal approach was evaluated through modulating the training set and system response duration. Our study demonstrated that the input of multi-modal eye-track and ERP features achieved superior performance of intention detection in the single trial classification of active search task. And compared with single-model ERP feature, this new strategy also induced congruent accuracy across different classifiers. Moreover, in comparison with other classification methods, we found that the SKLDA exhibited the superior performance when fusing feature in offline test (ACC=0.8783, AUC=0.9004) and online simulation with different sample amount and duration length. In sum, the current study revealed a novel and effective approach for intention classification using eye-brain hybrid BCI, and further supported the real-life application of hands-free HCI in a more precise and stable manner.

Anupam K. Gupta, Andrei Nakagawa, Nathan F. Lepora et al.

With the increase in interest in deployment of robots in unstructured environments to work alongside humans, the development of human-like sense of touch for robots becomes important. In this work, we implement a multi-channel neuromorphic tactile system that encodes contact events as discrete spike events that mimic the behavior of slow adapting mechanoreceptors. We study the impact of information pooling across artificial mechanoreceptors on classification performance of spatially non-uniform naturalistic textures. We encoded the spatio-temporal activation patterns of mechanoreceptors through gray-level co-occurrence matrix computed from time-varying mean spiking rate-based tactile response volume. We found that this approach greatly improved texture classification in comparison to use of individual mechanoreceptor response alone. In addition, the performance was also more robust to changes in sliding velocity. The importance of exploiting precise spatial and temporal correlations between sensory channels is evident from the fact that on either removal of precise temporal information or altering of spatial structure of response pattern, a significant performance drop was observed. This study thus demonstrates the superiority of population coding approaches that can exploit the precise spatio-temporal information encoded in activation patterns of mechanoreceptor populations. It, therefore, makes an advance in the direction of development of bio-inspired tactile systems required for realistic touch applications in robotics and prostheses.

Rohan Ghosh, Siyi Tang, Mahdi Rasouli et al.

Neuromorphic image sensors produce activity-driven spiking output at every pixel. These low-power consuming imagers which encode visual change information in the form of spikes help reduce computational overhead and realize complex real-time systems; object recognition and pose-estimation to name a few. However, there exists a lack of algorithms in event-based vision aimed towards capturing invariance to transformations. In this work, we propose a methodology for recognizing objects invariant to their pose with the Dynamic Vision Sensor (DVS). A novel slow-ELM architecture is proposed which combines the effectiveness of Extreme Learning Machines and Slow Feature Analysis. The system, tested on an Intel Core i5-4590 CPU, can perform 10,000 classifications per second and achieves 1% classification error for 8 objects with views accumulated over 90 degrees of 2D pose.

Rohan Ghosh, Anupam Gupta, Andrei Nakagawa et al.

In this paper, we address the challenging problem of action recognition, using event-based cameras. To recognise most gestural actions, often higher temporal precision is required for sampling visual information. Actions are defined by motion, and therefore, when using event-based cameras it is often unnecessary to re-sample the entire scene. Neuromorphic, event-based cameras have presented an alternative to visual information acquisition by asynchronously time-encoding pixel intensity changes, through temporally precise spikes (10 micro-second resolution), making them well equipped for action recognition. However, other challenges exist, which are intrinsic to event-based imagers, such as higher signal-to-noise ratio, and a spatiotemporally sparse information. One option is to convert event-data into frames, but this could result in significant temporal precision loss. In this work we introduce spatiotemporal filtering in the spike-event domain, as an alternative way of channeling spatiotemporal information through to a convolutional neural network. The filters are local spatiotemporal weight matrices, learned from the spike-event data, in an unsupervised manner. We find that appropriate spatiotemporal filtering significantly improves CNN performance beyond state-of-the-art on the event-based DVS Gesture dataset. On our newly recorded action recognition dataset, our method shows significant improvement when compared with other, standard ways of generating the spatiotemporal filters.

Rohan Ghosh, Anupam Gupta, Siyi Tang et al.

Unlike conventional frame-based sensors, event-based visual sensors output information through spikes at a high temporal resolution. By only encoding changes in pixel intensity, they showcase a low-power consuming, low-latency approach to visual information sensing. To use this information for higher sensory tasks like object recognition and tracking, an essential simplification step is the extraction and learning of features. An ideal feature descriptor must be robust to changes involving (i) local transformations and (ii) re-appearances of a local event pattern. To that end, we propose a novel spatiotemporal feature representation learning algorithm based on slow feature analysis (SFA). Using SFA, smoothly changing linear projections are learnt which are robust to local visual transformations. In order to determine if the features can learn to be invariant to various visual transformations, feature point tracking tasks are used for evaluation. Extensive experiments across two datasets demonstrate the adaptability of the spatiotemporal feature learner to translation, scaling and rotational transformations of the feature points. More importantly, we find that the obtained feature representations are able to exploit the high temporal resolution of such event-based cameras in generating better feature tracks.

Avinash Sharma, Wally Niu, Christopher L. Hunt et al.

Adjusting to amputation can often time be difficult for the body. Post-surgery, amputees have to wait for up to several months before receiving a properly fitted prosthesis. In recent years, there has been a trend toward quantitative outcome measures. In this paper, we developed the augmented reality (AR) version of one such measure, the Prosthetic Hand Assessment Measure (PHAM). The AR version of the PHAM - HoloPHAM, offers amputees the advantage to train with pattern recognition, at their own time and convenience, pre- and post-prosthesis fitting. We provide a rigorous analysis of our system, focusing on its ability to simulate reach, grasp, and touch in AR. Similarity of motion joint dynamics for reach in physical and AR space were compared, with experiments conducted to illustrate how depth in AR is perceived. To show the effectiveness and validity of our system for prosthesis training, we conducted a 10-day study with able-bodied subjects (N = 3) to see the effect that training on the HoloPHAM had on other established functional outcome measures. A washout phase of 5 days was incorporated to observe the effect without training. Comparisons were made with standardized outcome metrics, along with the progression of kinematic variability over time. Statistically significant (p<0.05) improvements were observed between pre- and post-training stages. Our results show that AR can be an effective tool for prosthesis training with pattern recognition systems, fostering motor learning for reaching movement tasks, and paving the possibility of replacing physical training.

Garrick Orchard, Cedric Meyer, Ralph Etienne-Cummings et al.

This paper introduces a spiking hierarchical model for object recognition which utilizes the precise timing information inherently present in the output of biologically inspired asynchronous Address Event Representation (AER) vision sensors. The asynchronous nature of these systems frees computation and communication from the rigid predetermined timing enforced by system clocks in conventional systems. Freedom from rigid timing constraints opens the possibility of using true timing to our advantage in computation. We show not only how timing can be used in object recognition, but also how it can in fact simplify computation. Specifically, we rely on a simple temporal-winner-take-all rather than more computationally intensive synchronous operations typically used in biologically inspired neural networks for object recognition. This approach to visual computation represents a major paradigm shift from conventional clocked systems and can find application in other sensory modalities and computational tasks. We showcase effectiveness of the approach by achieving the highest reported accuracy to date (97.5\%$\pm$3.5\%) for a previously published four class card pip recognition task and an accuracy of 84.9\%$\pm$1.9\% for a new more difficult 36 class character recognition task.