Justin Li

Asmita Yuki Pritha, Jason Xu, Daniel Ding et al.

Deep learning models for COVID-19 detection from chest CT scans generally perform well when the training and test data originate from the same institution, but they often struggle when scans are drawn from multiple centres with differing scanners, imaging protocols, and patient populations. One key reason is that existing methods treat COVID-19 classification as the sole training objective, without accounting for the data source of each scan. As a result, the learned representations tend to be biased toward centres that contribute more training data. To address this, we propose a multi-task learning approach in which the model is trained to predict both the COVID-19 diagnosis and the originating data centre. The two tasks share an EfficientNet-B7 backbone, which encourages the feature extractor to learn representations that hold across all four participating centres. Since the training data is not evenly distributed across sources, we apply a logit-adjusted cross-entropy loss [1] to the source classification head to prevent underrepresented centres from being overlooked. Our pre-processing follows the SSFL framework with KDS [2], selecting eight representative slices per scan. Our method achieves an F1 score of 0.9098 and an AUC-ROC of 0.9647 on a validation set of 308 scans. The code is publicly available at https://github.com/Purdue-M2/-multisource-covid-ct.

Hanna Rød, Dagny Streit, Nils Valseth Selte et al.

This paper investigates context stickiness in in-context learning (ICL), a phenomenon where earlier examples in a prompt interfere with a transformer's ability to adapt to later tasks. Using synthetic regression tasks over linear and quadratic functions, we examine how models trained under sequential, mixed, and random curricula handle abrupt task switches during inference. By sweeping over structured combinations of misleading linear examples followed by recovery quadratic examples, we quantify how prior context biases prediction error and how quickly models realign. Our results show strong evidence of persistent interference: more preceding linear examples reliably degrade quadratic predictions, while additional quadratic examples reduce error but with diminishing returns. We further find that training curricula significantly modulate resilience, with sequential training on the target function class yielding the fastest recovery, and surprisingly, random training producing the least robust behavior.

Justin Li, Dakang Zhang, Yifei Wang et al.

Stereoselective reactions (both chemical and enzymatic reactions) have been essential for origin of life, evolution, human biology and medicine. Since late 1960s, there have been numerous successes in the exciting new frontier of asymmetric catalysis. However, most industrial and academic asymmetric catalysis nowadays do follow the trial-and-error model, since the energetic difference for success or failure in asymmetric catalysis is incredibly small. Our current understanding about stereoselective reactions is mostly qualitative that stereoselectivity arises from differences in steric effects and electronic effects in multiple competing mechanistic pathways. Quantitatively understanding and modulating the stereoselectivity of for a given chemical reaction still remains extremely difficult. As a proof of principle, we herein present a novel machine learning technique, which combines a LASSO model and two Random Forest model via two Gaussian Mixture models, for quantitatively predicting stereoselectivity of chemical reactions. Compared to the recent ground-breaking approach [1], our approach is able to capture interactions between features and exploit complex data distributions, which are important for predicting stereoselectivity. Experimental results on a recently published dataset demonstrate that our approach significantly outperform [1]. The insight obtained from our results provide a solid foundation for further exploration of other synthetically valuable yet mechanistically intriguing stereoselective reactions.

Tong Yang, Long Sha, Justin Li et al.

In this work, we developed a deep learning model-based approach to forecast the spreading trend of SARS-CoV-2 in the United States. We implemented the designed model using the United States to confirm cases and state demographic data and achieved promising trend prediction results. The model incorporates demographic information and epidemic time-series data through a Gated Recurrent Unit structure. The identification of dominating demographic factors is delivered in the end.