Hongxin Ding

Hongxin Ding, Peinie Zou, Zhiyuan Wang et al.

Extracting medical knowledge from healthcare texts enhances downstream tasks like medical knowledge graph construction and clinical decision-making. However, the construction and application of knowledge extraction models lack automation, reusability and unified management, leading to inefficiencies for researchers and high barriers for non-AI experts such as doctors, to utilize knowledge extraction. To address these issues, we propose a ModelOps-based intelligent medical knowledge extraction framework that offers a low-code system for model selection, training, evaluation and optimization. Specifically, the framework includes a dataset abstraction mechanism based on multi-layer callback functions, a reusable model training, monitoring and management mechanism. We also propose a model recommendation method based on dataset similarity, which helps users quickly find potentially suitable models for a given dataset. Our framework provides convenience for researchers to develop models and simplifies model access for non-AI experts such as doctors.

Hongxin Ding, Yue Fang, Runchuan Zhu et al.

Large Language Models(LLMs) excel in general tasks but struggle in specialized domains like healthcare due to limited domain-specific knowledge.Supervised Fine-Tuning(SFT) data construction for domain adaptation often relies on heuristic methods, such as GPT-4 annotation or manual data selection, with a data-centric focus on presumed diverse, high-quality datasets. However, these methods overlook the model's inherent knowledge distribution, introducing noise, redundancy, and irrelevant data, leading to a mismatch between the selected data and the model's learning task, resulting in suboptimal performance. To address this, we propose a two-stage model-centric data selection framework, Decomposed Difficulty Data Selection (3DS), which aligns data with the model's knowledge distribution for optimized adaptation. In Stage1, we apply Prompt-Driven Data Selection via Explicit Alignment, where the the model filters irrelevant or redundant data based on its internal knowledge. In Stage2, we perform Decomposed Difficulty Data Selection, where data selection is guided by our defined difficulty decomposition, using three metrics: Instruction Understanding, Response Confidence, and Response Correctness. Additionally, an attention-based importance weighting mechanism captures token importance for more accurate difficulty calibration. This two-stage approach ensures the selected data is not only aligned with the model's knowledge and preferences but also appropriately challenging for the model to learn, leading to more effective and targeted domain adaptation. In the case study of the medical domain, our extensive experiments on real-world healthcare datasets demonstrate the superiority of 3DS over exisiting methods in accuracy by over 5.29%. Our dataset and code has been open-sourced at https://github.com/PuppyKnightUniversity/3DS.

Yue Fang, Yuxin Guo, Jiaran Gao et al.

Improving large language models (LLMs) for electronic health record (EHR) reasoning is essential for enabling accurate and generalizable clinical predictions. While LLMs excel at medical text understanding, they underperform on EHR-based prediction tasks due to challenges in modeling temporally structured, high-dimensional data. Existing approaches often rely on hybrid paradigms, where LLMs serve merely as frozen prior retrievers while downstream deep learning (DL) models handle prediction, failing to improve the LLM's intrinsic reasoning capacity and inheriting the generalization limitations of DL models. To this end, we propose EAG-RL, a novel two-stage training framework designed to intrinsically enhance LLMs' EHR reasoning ability through expert attention guidance, where expert EHR models refer to task-specific DL models trained on EHR data. Concretely, EAG-RL first constructs high-quality, stepwise reasoning trajectories using expert-guided Monte Carlo Tree Search to effectively initialize the LLM's policy. Then, EAG-RL further optimizes the policy via reinforcement learning by aligning the LLM's attention with clinically salient features identified by expert EHR models. Extensive experiments on two real-world EHR datasets show that EAG-RL improves the intrinsic EHR reasoning ability of LLMs by an average of 14.62%, while also enhancing robustness to feature perturbations and generalization to unseen clinical domains. These results demonstrate the practical potential of EAG-RL for real-world deployment in clinical prediction tasks. Our code have been available at https://github.com/devilran6/EAG-RL.

Hongxin Ding, Baixiang Huang, Yue Fang et al.

Rubric-based rewards offer interpretable and fine-grained optimization signals for reinforcement learning in open-ended tasks where verifiable answers are unavailable. However, pre-constructed rubrics remain static throughout training, creating a fundamental mismatch with the evolving policy: fixed criteria gradually lose discriminative power as the model improves, leading to reward saturation and potential hacking. Recent dynamic rubric methods partially address this but rely on external frontier models or ground-truth answers, and update rubrics only at coarse granularity. We propose EvoRubrics, a co-evolutionary RL framework where a Policy LLM and a Rubric Generator jointly improve through adversarial interaction within each training step. As the policy improves under the rubric generator's guidance, the rubric generator adapts its criteria to remain discriminative and informative, enabling evaluation to track the policy in real time and naturally inducing an automatic curriculum. Experiments show that EvoRubrics consistently outperforms static and dynamic rubric baselines across benchmarks. The learned Rubric Generator further generalizes as a transferable reward model. Notably, even a fully self-supervised variant without any external supervision achieves meaningful gains, suggesting that co-evolution between generation and evaluation alone can provide sufficiently rich learning signals. Our code is publicly available at https://anonymous.4open.science/r/EvoRubrics-2155/.

Xinke Jiang, Ruizhe Zhang, Yongxin Xu et al.

In this paper, we investigate the retrieval-augmented generation (RAG) based on Knowledge Graphs (KGs) to improve the accuracy and reliability of Large Language Models (LLMs). Recent approaches suffer from insufficient and repetitive knowledge retrieval, tedious and time-consuming query parsing, and monotonous knowledge utilization. To this end, we develop a Hypothesis Knowledge Graph Enhanced (HyKGE) framework, which leverages LLMs' powerful reasoning capacity to compensate for the incompleteness of user queries, optimizes the interaction process with LLMs, and provides diverse retrieved knowledge. Specifically, HyKGE explores the zero-shot capability and the rich knowledge of LLMs with Hypothesis Outputs to extend feasible exploration directions in the KGs, as well as the carefully curated prompt to enhance the density and efficiency of LLMs' responses. Furthermore, we introduce the HO Fragment Granularity-aware Rerank Module to filter out noise while ensuring the balance between diversity and relevance in retrieved knowledge. Experiments on two Chinese medical multiple-choice question datasets and one Chinese open-domain medical Q&A dataset with two LLM turbos demonstrate the superiority of HyKGE in terms of accuracy and explainability.