Sudha Ram

Shuang Geng, Wenli Zhang, Jiaheng Xie et al.

Online healthcare consultations have transformed how patients seek medical advice, offering convenience while introducing new challenges for ensuring consultation success. Predicting whether an online consultation will be successful is critical for improving patient experiences and sustaining platform competitiveness. Yet, such prediction is inherently difficult due to the fragmented nature of patients' care journeys and the lack of integration between virtual and traditional healthcare systems. Furthermore, the data collected from online platforms, including textual conversations, interaction sequences, and behavioral traces, are often sparse and incomplete. This study develops a predictive modeling approach that fuses multimodal data and dynamically constructed knowledge networks to capture latent relationships among patients, physicians, and consultation contexts. By integrating heterogeneous information sources and uncovering the evolving structure of digital interactions, the model enhances the accuracy and interpretability of consultation success prediction. The findings offer implications for designing hybrid healthcare ecosystems that combine online and offline services through data-driven intelligence.

Shuang Geng, Wenli Zhang, Jiaheng Xie et al.

Social media user-generated content (UGC) provides real-time, self-reported indicators of mental health conditions such as depression, offering a valuable source for predictive analytics. While prior studies integrate medical knowledge to improve prediction accuracy, they overlook the opportunity to simultaneously expand such knowledge through predictive processes. We develop a Closed-Loop Large Language Model (LLM)-Knowledge Graph framework that integrates prediction and knowledge expansion in an iterative learning cycle. In the knowledge-aware depression detection phase, the LLM jointly performs depression detection and entity extraction, while the knowledge graph represents and weights these entities to refine prediction performance. In the knowledge refinement and expansion phase, new entities, relationships, and entity types extracted by the LLM are incorporated into the knowledge graph under expert supervision, enabling continual knowledge evolution. Using large-scale UGC, the framework enhances both predictive accuracy and medical understanding. Expert evaluations confirmed the discovery of clinically meaningful symptoms, comorbidities, and social triggers complementary to existing literature. We conceptualize and operationalize prediction-through-learning and learning-through-prediction as mutually reinforcing processes, advancing both methodological and theoretical understanding in predictive analytics. The framework demonstrates the co-evolution of computational models and domain knowledge, offering a foundation for adaptive, data-driven knowledge systems applicable to other dynamic risk monitoring contexts.

Haoxin Liu, Wenli Zhang, Jiaheng Xie et al.

This study harnesses state-of-the-art AI technology for detecting mental disorders through user-generated textual content. Existing studies typically rely on fully supervised machine learning, which presents challenges such as the labor-intensive manual process of annotating extensive training data for each research problem and the need to design specialized deep learning architectures for each task. We propose a novel method to address these challenges by leveraging large language models and continuous multi-prompt engineering, which offers two key advantages: (1) developing personalized prompts that capture each user's unique characteristics and (2) integrating structured medical knowledge into prompts to provide context for disease detection and facilitate predictive modeling. We evaluate our method using three widely prevalent mental disorders as research cases. Our method significantly outperforms existing methods, including feature engineering, architecture engineering, and discrete prompt engineering. Meanwhile, our approach demonstrates success in few-shot learning, i.e., requiring only a minimal number of training examples. Moreover, our method can be generalized to other rare mental disorder detection tasks with few positive labels. In addition to its technical contributions, our method has the potential to enhance the well-being of individuals with mental disorders and offer a cost-effective, accessible alternative for stakeholders beyond traditional mental disorder screening methods.