Jiakai Zhang

Jiakai Zhang, Qihe Chen, Yan Zeng et al.

In the past decade, deep conditional generative models have revolutionized the generation of realistic images, extending their application from entertainment to scientific domains. Single-particle cryo-electron microscopy (cryo-EM) is crucial in resolving near-atomic resolution 3D structures of proteins, such as the SARS- COV-2 spike protein. To achieve high-resolution reconstruction, a comprehensive data processing pipeline has been adopted. However, its performance is still limited as it lacks high-quality annotated datasets for training. To address this, we introduce physics-informed generative cryo-electron microscopy (CryoGEM), which for the first time integrates physics-based cryo-EM simulation with a generative unpaired noise translation to generate physically correct synthetic cryo-EM datasets with realistic noises. Initially, CryoGEM simulates the cryo-EM imaging process based on a virtual specimen. To generate realistic noises, we leverage an unpaired noise translation via contrastive learning with a novel mask-guided sampling scheme. Extensive experiments show that CryoGEM is capable of generating authentic cryo-EM images. The generated dataset can used as training data for particle picking and pose estimation models, eventually improving the reconstruction resolution.

Di Cao, Xianchen Wang, Junfeng Zhou et al.

Traditional Time Delay Neural Networks (TDNN) have achieved state-of-the-art performance at the cost of high computational complexity and slower inference speed, making them difficult to implement in an industrial environment. The Densely Connected Time Delay Neural Network (D-TDNN) with Context Aware Masking (CAM) module has proven to be an efficient structure to reduce complexity while maintaining system performance. In this paper, we propose a fast and lightweight model, LightCAM, which further adopts a depthwise separable convolution module (DSM) and uses multi-scale feature aggregation (MFA) for feature fusion at different levels. Extensive experiments are conducted on VoxCeleb dataset, the comparative results show that it has achieved an EER of 0.83 and MinDCF of 0.0891 in VoxCeleb1-O, which outperforms the other mainstream speaker verification methods. In addition, complexity analysis further demonstrates that the proposed architecture has lower computational cost and faster inference speed.