Cheng Luo

Yuhong Jiao, Jiaqing Miao, Jinnan Gong et al.

Schizophrenia is a serious psychiatric disorder. Its pathogenesis is not completely clear, making it difficult to treat patients precisely. Because of the complicated non-Euclidean network structure of the human brain, learning critical information from brain networks remains difficult. To effectively capture the topological information of brain neural networks, a novel multimodal graph attention network based on sparse interaction mechanism (Multi-SIGATnet) was proposed for SZ classification was proposed for SZ classification. Firstly, structural and functional information were fused into multimodal data to obtain more comprehensive and abundant features for patients with SZ. Subsequently, a sparse interaction mechanism was proposed to effectively extract salient features and enhance the feature representation capability. By enhancing the strong connections and weakening the weak connections between feature information based on an asymmetric convolutional network, high-order interactive features were captured. Moreover, sparse learning strategies were designed to filter out redundant connections to improve model performance. Finally, local and global features were updated in accordance with the topological features and connection weight constraints of the higher-order brain network, the features being projected to the classification target space for disorder classification. The effectiveness of the model is verified on the Center for Biomedical Research Excellence (COBRE) and University of California Los Angeles (UCLA) datasets, achieving 81.9\% and 75.8\% average accuracy, respectively, 4.6\% and 5.5\% higher than the graph attention network (GAT) method. Experiments showed that the Multi-SIGATnet method exhibited good performance in identifying SZ.

Cheng Luo, Richard Yi Da Xu, Yang Xiang

When observations are organized into groups where commonalties exist amongst them, the dependent random measures can be an ideal choice for modeling. One of the propositions of the dependent random measures is that the atoms of the posterior distribution are shared amongst groups, and hence groups can borrow information from each other. When normalized dependent random measures prior with independent increments are applied, we can derive appropriate exchangeable probability partition function (EPPF), and subsequently also deduce its inference algorithm given any mixture model likelihood. We provide all necessary derivation and solution to this framework. For demonstration, we used mixture of Gaussians likelihood in combination with a dependent structure constructed by linear combinations of CRMs. Our experiments show superior performance when using this framework, where the inferred values including the mixing weights and the number of clusters both respond appropriately to the number of completely random measure used.