Hanyu Chen

Zhuokang Shen, Yifan Wang, Hanyu Chen et al.

Recent advances in large language models (LLMs) have enabled increasingly capable chatbots. However, most existing systems focus on single-user settings and do not generalize well to multi-user group chats, where agents require more proactive and accurate intervention under complex, evolving contexts. Existing approaches typically rely on LLMs for both reasoning and generation, leading to high token consumption, limited scalability, and potential privacy risks. To address these challenges, we propose GroupGPT, a token-efficient and privacy-preserving agentic framework for multi-user chat assistant. GroupGPT adopts a small-large model collaborative architecture to decouple intervention timing from response generation, enabling efficient and accurate decision-making. The framework also supports multimodal inputs, including memes, images, videos, and voice messages. We further introduce MUIR, a benchmark dataset for multi-user chat assistant intervention reasoning. MUIR contains 2,500 annotated group chat segments with intervention labels and rationales, supporting evaluation of timing accuracy and response quality. We evaluate a range of models on MUIR, from large language models to smaller counterparts. Extensive experiments demonstrate that GroupGPT produces accurate and well-timed responses, achieving an average score of 4.72/5.0 in LLM-based evaluation, and is well received by users across diverse group chat scenarios. Moreover, GroupGPT reduces token usage by up to 3 times compared to baseline methods, while providing privacy sanitization of user messages before cloud transmission. Code is available at: https://github.com/Eliot-Shen/GroupGPT .

Wenhui Lei, Anqi Li, Yusheng Tan et al.

Foundation Models (FMs) in computational pathology (CPath) have significantly advanced the extraction of meaningful features from histopathology image datasets, achieving strong performance across various clinical tasks. Despite their impressive performance, these models often exhibit variability when applied to different tasks, prompting the need for a unified framework capable of consistently excelling across various applications. In this work, we propose Shazam, a novel framework designed to efficiently combine multiple CPath models. Unlike previous approaches that train a fixed-parameter FM, Shazam dynamically extracts and refines information from diverse FMs for each specific task. To ensure that each FM contributes effectively without dominance, a novel distillation strategy is applied, guiding the student model with features from all teacher models, which enhances its generalization ability. Experimental results on two pathology patch classification datasets demonstrate that Shazam outperforms existing CPath models and other fusion methods. Its lightweight, flexible design makes it a promising solution for improving CPath analysis in real-world settings. Code will be available at https://github.com/Tuner12/Shazam.

Wenhui Lei, Hanyu Chen, Zitian Zhang et al.

AI-assisted imaging made substantial advances in tumor diagnosis and management. However, a major barrier to developing robust oncology foundation models is the scarcity of large-scale, high-quality annotated datasets, which are limited by privacy restrictions and the high cost of manual labeling. To address this gap, we present PASTA, a pan-tumor radiology foundation model built on PASTA-Gen, a synthetic data framework that generated 30,000 3D CT scans with pixel-level lesion masks and structured reports of tumors across ten organ systems. Leveraging this resource, PASTA achieves state-of-the-art performance on 45 of 46 oncology tasks, including non-contrast CT tumor screening, lesion segmentation, structured reporting, tumor staging, survival prediction, and MRI-modality transfer. To assess clinical applicability, we developed PASTA-AID, a clinical decision support system, and ran a retrospective simulated clinical trial across two scenarios. For pan-tumor screening on plain CT with fixed reading time, PASTA-AID increased radiologists' throughput by 11.1-25.1% and improved sensitivity by 17.0-31.4% and precision by 10.5-24.9%; additionally, in a diagnosis-aid workflow, it reduced segmentation time by up to 78.2% and reporting time by up to 36.5%. Beyond gains in accuracy and efficiency, PASTA-AID narrowed the expertise gap, enabling less-experienced radiologists to approach expert-level performance. Together, this work establishes an end-to-end, synthetic data-driven pipeline spanning data generation, model development, and clinical validation, thereby demonstrating substantial potential for pan-tumor research and clinical translation.