LGMar 14, 2022Code
MetaBalance: Improving Multi-Task Recommendations via Adapting Gradient Magnitudes of Auxiliary TasksYun He, Xue Feng, Cheng Cheng et al.
In many personalized recommendation scenarios, the generalization ability of a target task can be improved via learning with additional auxiliary tasks alongside this target task on a multi-task network. However, this method often suffers from a serious optimization imbalance problem. On the one hand, one or more auxiliary tasks might have a larger influence than the target task and even dominate the network weights, resulting in worse recommendation accuracy for the target task. On the other hand, the influence of one or more auxiliary tasks might be too weak to assist the target task. More challenging is that this imbalance dynamically changes throughout the training process and varies across the parts of the same network. We propose a new method: MetaBalance to balance auxiliary losses via directly manipulating their gradients w.r.t the shared parameters in the multi-task network. Specifically, in each training iteration and adaptively for each part of the network, the gradient of an auxiliary loss is carefully reduced or enlarged to have a closer magnitude to the gradient of the target loss, preventing auxiliary tasks from being so strong that dominate the target task or too weak to help the target task. Moreover, the proximity between the gradient magnitudes can be flexibly adjusted to adapt MetaBalance to different scenarios. The experiments show that our proposed method achieves a significant improvement of 8.34% in terms of NDCG@10 upon the strongest baseline on two real-world datasets. The code of our approach can be found at here: https://github.com/facebookresearch/MetaBalance
61.1NAMay 30
Stabilization-Free H(curl) and H(div)-Conforming Virtual Element MethodYuxuan Liao, Xue Feng, Yidong Huang
Standard Virtual Element Method (VEM) requires stabilization terms that significantly affect the numerical computation performance. In this work, we propose a stabilization-free VEM for general order \(\mathbf{H}(\operatorname{\mathbf{curl}})\) and \(\mathbf{H}(\operatorname{div})\)-conforming spaces by constructing novel serendipity projectors and corresponding serendipity spaces with minimum number of DoFs. Our approach handles the full De Rham complex chain in \(\mathbb{R}^3\) while preserving essential properties including boundary continuity and commutativity. Since the number of DoFs are minimized, computational overhead is greatly reduced. The optimal approximation properties are rigorously proven and validated through Maxwell eigenvalue problems with numerical experiments.
88.8GTJun 3
Learning to cooperate with emergent reputation via multi-agent reinforcement learningXinwei Song, Yizhe Huang, Dengji Zhao et al.
Reputation, the aggregation of peer assessments diffused through social networks, is a pivotal mechanism for promoting cooperation in social dilemmas ubiquitous to distributed multi-agent systems comprising agents with limited perception and cognitive capabilities. Exploring efficient reputation systems, comprising reputation assessment rules and reputation-based policies, is a long-standing challenge. Previous work assumes predefined reputation assessment rules or models reputation as an intrinsic reward to learn policies, compromising the methods' ability for generalization and adaptation. To address this, we propose a distributed multi-agent reinforcement learning method $\textbf{COOPER}$ ($\textbf{COOP}$eration with $\textbf{E}$mergent $\textbf{R}$eputation), which jointly learns reputation assessment rules and reputation-based policies entirely from environment rewards. Notably, leveraging the underlying mechanisms of reputation, we deliberately design the constituent modules of $\textbf{COOPER}$ and the data flows among them, overcoming the latency and noise in the feedback signal, caused by the deep entanglement between reputation and policy. Experiments on the donation game and the coin game in grid world environments demonstrate that $\textbf{COOPER}$ effectively adapts to various existing reputation systems and co-players. Furthermore, we observe the co-emergence of reputation norms and cooperation in self-play settings. These results hold robustly across diverse social network topologies, underscoring the generalizability and efficacy of our approach.
CYMar 3Code
Credibility Governance: A Social Mechanism for Collective Self-Correction under Weak Truth SignalsWanying He, Yanxi Lin, Ziheng Zhou et al.
Online platforms increasingly rely on opinion aggregation to allocate real-world attention and resources, yet common signals such as engagement votes or capital-weighted commitments are easy to amplify and often track visibility rather than reliability. This makes collective judgments brittle under weak truth signals, noisy or delayed feedback, early popularity surges, and strategic manipulation. We propose Credibility Governance (CG), a mechanism that reallocates influence by learning which agents and viewpoints consistently track evolving public evidence. CG maintains dynamic credibility scores for both agents and opinions, updates opinion influence via credibility-weighted endorsements, and updates agent credibility based on the long-run performance of the opinions they support, rewarding early and persistent alignment with emerging evidence while filtering short-lived noise. We evaluate CG in POLIS, a socio-physical simulation environment that models coupled belief dynamics and downstream feedback under uncertainty. Across settings with initial majority misalignment, observation noise and contamination, and misinformation shocks, CG outperforms vote-based, stake-weighted, and no-governance baselines, yielding faster recovery to the true state, reduced lock-in and path dependence, and improved robustness under adversarial pressure. Our implementation and experimental scripts are publicly available at https://github.com/Wanying-He/Credibility_Governance.
AIDec 3, 2025
Evaluating Generalization Capabilities of LLM-Based Agents in Mixed-Motive Scenarios Using ConcordiaChandler Smith, Marwa Abdulhai, Manfred Diaz et al.
Large Language Model (LLM) agents have demonstrated impressive capabilities for social interaction and are increasingly being deployed in situations where they might engage with both human and artificial agents. These interactions represent a critical frontier for LLM-based agents, yet existing evaluation methods fail to measure how well these capabilities generalize to novel social situations. In this paper, we introduce a method for evaluating the ability of LLM-based agents to cooperate in zero-shot, mixed-motive environments using Concordia, a natural language multi-agent simulation environment. Our method measures general cooperative intelligence by testing an agent's ability to identify and exploit opportunities for mutual gain across diverse partners and contexts. We present empirical results from the NeurIPS 2024 Concordia Contest, where agents were evaluated on their ability to achieve mutual gains across a suite of diverse scenarios ranging from negotiation to collective action problems. Our findings reveal significant gaps between current agent capabilities and the robust generalization required for reliable cooperation, particularly in scenarios demanding persuasion and norm enforcement.
70.4LGMay 15Code
Convex Dataset Valuation for Post-TrainingSiqi Zeng, Christopher Jung, Rui Li et al.
Improving LLM performance on downstream tasks sometimes requires leveraging auxiliary datasets during post-training. In practice, however, developers face constraints on compute, labeling, and licensing costs that preclude using all available data, necessitating principled dataset-level selection. These constraints are increasingly shaped by dataset marketplaces, where data acquisition is governed by budgets and negotiation. We study dataset valuation as a subset selection problem during LLM post-training. Our goal is to identify and weight auxiliary datasets so as to maximize target task performance given constrained budgets. We first show that commonly used gradient alignment scores provide a reasonable yet incomplete valuation signal, as they ignore redundancy among datasets. To address this, we propose a scalable convex dataset-level valuation method based on kernel mean matching (KMM) in gradient space, which jointly accounts for alignment with the target task and redundancy across auxiliary datasets. Through extensive experiments across diverse post-training settings and tasks, we show that our approach consistently outperforms existing valuation baselines, achieving stronger performance with low computational overhead. Our results position dataset valuation as a practical decision tool for post-training data selection in market-constrained large language model settings. The code is available at https://github.com/uiuctml/convex_data_valuation.
CVFeb 5, 2023
Active Learning in Brain Tumor Segmentation with Uncertainty Sampling, Annotation Redundancy Restriction, and Data InitializationDaniel D Kim, Rajat S Chandra, Jian Peng et al.
Deep learning models have demonstrated great potential in medical 3D imaging, but their development is limited by the expensive, large volume of annotated data required. Active learning (AL) addresses this by training a model on a subset of the most informative data samples without compromising performance. We compared different AL strategies and propose a framework that minimizes the amount of data needed for state-of-the-art performance. 638 multi-institutional brain tumor MRI images were used to train a 3D U-net model and compare AL strategies. We investigated uncertainty sampling, annotation redundancy restriction, and initial dataset selection techniques. Uncertainty estimation techniques including Bayesian estimation with dropout, bootstrapping, and margins sampling were compared to random query. Strategies to avoid annotation redundancy by removing similar images within the to-be-annotated subset were considered as well. We determined the minimum amount of data necessary to achieve similar performance to the model trained on the full dataset (α = 0.1). A variance-based selection strategy using radiomics to identify the initial training dataset is also proposed. Bayesian approximation with dropout at training and testing showed similar results to that of the full data model with less than 20% of the training data (p=0.293) compared to random query achieving similar performance at 56.5% of the training data (p=0.814). Annotation redundancy restriction techniques achieved state-of-the-art performance at approximately 40%-50% of the training data. Radiomics dataset initialization had higher Dice with initial dataset sizes of 20 and 80 images, but improvements were not significant. In conclusion, we investigated various AL strategies with dropout uncertainty estimation achieving state-of-the-art performance with the least annotated data.
36.5MAMay 23
Adaptive Punishment for Cooperation in Mixed-Motive GamesMin Tang, Fanqi Kong, Linyuan Lü et al.
Mixed-motive scenarios are ubiquitous in real-world multi-agent interactions, where self-interested agents often defect for immediate rewards, overlooking the potential of altruistic cooperation to improve long-term gains and collective welfare. Peer punishment can deter defection, but as costly second-order altruism, its persistent imposition may undermine the punisher's interests. Existing approaches often struggle to effectively implement punishment to promote cooperation. To balance the efficacy and cost of punishment, we propose Adaptive Punishment for Cooperation (APC), a distributed method that determines punishment intensity based on both a dynamic punishment probability and the severity of defection. This dynamic probability substantially reduces costly and ineffective punishment while also promotes cooperation. To accurately assess defection and its severity, we use a defection awareness module, whose learning is guided by game reward. Theoretical analysis and empirical results show APC performs effectively in iterated public goods game. Empirically, APC also significantly outperforms existing baselines across sequential social dilemmas, learning rational and effective punishment policies that foster cooperation by strategically deterring defection.
MANov 6, 2024Code
AdaSociety: An Adaptive Environment with Social Structures for Multi-Agent Decision-MakingYizhe Huang, Xingbo Wang, Hao Liu et al.
Traditional interactive environments limit agents' intelligence growth with fixed tasks. Recently, single-agent environments address this by generating new tasks based on agent actions, enhancing task diversity. We consider the decision-making problem in multi-agent settings, where tasks are further influenced by social connections, affecting rewards and information access. However, existing multi-agent environments lack a combination of adaptive physical surroundings and social connections, hindering the learning of intelligent behaviors. To address this, we introduce AdaSociety, a customizable multi-agent environment featuring expanding state and action spaces, alongside explicit and alterable social structures. As agents progress, the environment adaptively generates new tasks with social structures for agents to undertake. In AdaSociety, we develop three mini-games showcasing distinct social structures and tasks. Initial results demonstrate that specific social structures can promote both individual and collective benefits, though current reinforcement learning and LLM-based algorithms show limited effectiveness in leveraging social structures to enhance performance. Overall, AdaSociety serves as a valuable research platform for exploring intelligence in diverse physical and social settings. The code is available at https://github.com/bigai-ai/AdaSociety.
53.1LGMar 30
Expectation Error Bounds for Transfer Learning in Linear Regression and Linear Neural NetworksMeitong Liu, Christopher Jung, Rui Li et al.
In transfer learning, the learner leverages auxiliary data to improve generalization on a main task. However, the precise theoretical understanding of when and how auxiliary data help remains incomplete. We provide new insights on this issue in two canonical linear settings: ordinary least squares regression and under-parameterized linear neural networks. For linear regression, we derive exact closed-form expressions for the expected generalization error with bias-variance decomposition, yielding necessary and sufficient conditions for auxiliary tasks to improve generalization on the main task. We also derive globally optimal task weights as outputs of solvable optimization programs, with consistency guarantees for empirical estimates. For linear neural networks with shared representations of width $q \leq K$, where $K$ is the number of auxiliary tasks, we derive a non-asymptotic expectation bound on the generalization error, yielding the first non-vacuous sufficient condition for beneficial auxiliary learning in this setting, as well as principled directions for task weight curation. We achieve this by proving a new column-wise low-rank perturbation bound for random matrices, which improves upon existing bounds by preserving fine-grained column structures. Our results are verified on synthetic data simulated with controlled parameters.
99.1ROMar 19
Aegis: Automated Error Generation and Attribution for Multi-Agent SystemsFanqi Kong, Ruijie Zhang, Huaxiao Yin et al.
Large language model based multi-agent systems (MAS) have unlocked significant advancements in tackling complex problems, but their increasing capability introduces a structural fragility that makes them difficult to debug. A key obstacle to improving their reliability is the severe scarcity of large-scale, diverse datasets for error attribution, as existing resources rely on costly and unscalable manual annotation. To address this bottleneck, we introduce Aegis, a novel framework for Automated error generation and attribution for multi-agent systems. Aegis constructs a large dataset of 9,533 trajectories with annotated faulty agents and error modes, covering diverse MAS architectures and task domains. This is achieved using a LLM-based manipulator that can adaptively inject context-aware errors into successful execution trajectories. Leveraging fine-grained labels and the structured arrangement of positive-negative sample pairs, Aegis supports three different learning paradigms: Supervised Fine-Tuning, Reinforcement Learning, and Contrastive Learning. We develop learning methods for each paradigm. Comprehensive experiments show that trained models consistently achieve substantial improvements in error attribution. Notably, several of our fine-tuned LLMs demonstrate performance competitive with or superior to proprietary models an order of magnitude larger, validating our automated data generation framework as a crucial resource for developing more robust and interpretable multi-agent systems. Our project website is available at https://kfq20.github.io/Aegis-Website/.
IRDec 11, 2024Code
Preference Discerning with LLM-Enhanced Generative RetrievalFabian Paischer, Liu Yang, Linfeng Liu et al.
In sequential recommendation, models recommend items based on user's interaction history. To this end, current models usually incorporate information such as item descriptions and user intent or preferences. User preferences are usually not explicitly given in open-source datasets, and thus need to be approximated, for example via large language models (LLMs). Current approaches leverage approximated user preferences only during training and rely solely on the past interaction history for recommendations, limiting their ability to dynamically adapt to changing preferences, potentially reinforcing echo chambers. To address this issue, we propose a new paradigm, namely preference discerning, which explicitly conditions a generative recommendation model on user preferences in natural language within its context. To evaluate preference discerning, we introduce a novel benchmark that provides a holistic evaluation across various scenarios, including preference steering and sentiment following. Upon evaluating current state-of-the-art methods on our benchmark, we discover that their ability to dynamically adapt to evolving user preferences is limited. To address this, we propose a new method named Mender ($\textbf{M}$ultimodal Prefer$\textbf{en}$ce $\textbf{D}$iscern$\textbf{er}$), which achieves state-of-the-art performance in our benchmark. Our results show that Mender effectively adapts its recommendation guided by human preferences, even if not observed during training, paving the way toward more flexible recommendation models.
IVDec 19, 2021Code
QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - Analysis of Ranking Scores and Benchmarking ResultsRaghav Mehta, Angelos Filos, Ujjwal Baid et al.
Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g., tumor and lesion sub-regions) is particularly challenging, and potential errors hinder translating DL models into clinical workflows. Quantifying the reliability of DL model predictions in the form of uncertainties could enable clinical review of the most uncertain regions, thereby building trust and paving the way toward clinical translation. Several uncertainty estimation methods have recently been introduced for DL medical image segmentation tasks. Developing scores to evaluate and compare the performance of uncertainty measures will assist the end-user in making more informed decisions. In this study, we explore and evaluate a score developed during the BraTS 2019 and BraTS 2020 task on uncertainty quantification (QU-BraTS) and designed to assess and rank uncertainty estimates for brain tumor multi-compartment segmentation. This score (1) rewards uncertainty estimates that produce high confidence in correct assertions and those that assign low confidence levels at incorrect assertions, and (2) penalizes uncertainty measures that lead to a higher percentage of under-confident correct assertions. We further benchmark the segmentation uncertainties generated by 14 independent participating teams of QU-BraTS 2020, all of which also participated in the main BraTS segmentation task. Overall, our findings confirm the importance and complementary value that uncertainty estimates provide to segmentation algorithms, highlighting the need for uncertainty quantification in medical image analyses. Finally, in favor of transparency and reproducibility, our evaluation code is made publicly available at: https://github.com/RagMeh11/QU-BraTS.
41.8MAMay 9
Modeling Decision-Making with Will for Cooperation in Social DilemmasYizhe Huang, Bin Ling, Song-Chun Zhu et al.
Standard rational actor models often attribute cooperation failures in social dilemmas to insufficient incentives, overlooking the destabilizing effects of continuous utility maximization. To address this, we propose a framework of ``will" defined as a mechanism that persistently pursues goals while ignoring local cost-benefit fluctuations. We formalize the Willed Agents as potential minimizers, distinguishing them from cumulative utility maximization. Dynamical analysis of infinite population demonstrates that willed agents shrink the feasible state space, acting as boundary constraints that accelerate convergence in canonical social dilemmas. Through multi-agent simulations in a spatiotemporal Stag Hunt Game, we show that willed agents function as ``cooperation catalysts", enabling groups to surmount high-risk thresholds where purely utility maximization fails. We find that heterogeneous will strength promotes cooperation, and that agents who autonomously suspend rational re-evaluation can significantly outperform continuous optimizers. These findings suggest that successful cooperation relies on the cognitive capacity to strategically constrain calculation.
LGJan 9
Learn to Evolve: Self-supervised Neural JKO Operator for Wasserstein Gradient FlowXue Feng, Li Wang, Deanna Needell et al.
The Jordan-Kinderlehrer-Otto (JKO) scheme provides a stable variational framework for computing Wasserstein gradient flows, but its practical use is often limited by the high computational cost of repeatedly solving the JKO subproblems. We propose a self-supervised approach for learning a JKO solution operator without requiring numerical solutions of any JKO trajectories. The learned operator maps an input density directly to the minimizer of the corresponding JKO subproblem, and can be iteratively applied to efficiently generate the gradient-flow evolution. A key challenge is that only a number of initial densities are typically available for training. To address this, we introduce a Learn-to-Evolve algorithm that jointly learns the JKO operator and its induced trajectories by alternating between trajectory generation and operator updates. As training progresses, the generated data increasingly approximates true JKO trajectories. Meanwhile, this Learn-to-Evolve strategy serves as a natural form of data augmentation, significantly enhancing the generalization ability of the learned operator. Numerical experiments demonstrate the accuracy, stability, and robustness of the proposed method across various choices of energies and initial conditions.
IRNov 27, 2024
Unifying Generative and Dense Retrieval for Sequential RecommendationLiu Yang, Fabian Paischer, Kaveh Hassani et al.
Sequential dense retrieval models utilize advanced sequence learning techniques to compute item and user representations, which are then used to rank relevant items for a user through inner product computation between the user and all item representations. However, this approach requires storing a unique representation for each item, resulting in significant memory requirements as the number of items grow. In contrast, the recently proposed generative retrieval paradigm offers a promising alternative by directly predicting item indices using a generative model trained on semantic IDs that encapsulate items' semantic information. Despite its potential for large-scale applications, a comprehensive comparison between generative retrieval and sequential dense retrieval under fair conditions is still lacking, leaving open questions regarding performance, and computation trade-offs. To address this, we compare these two approaches under controlled conditions on academic benchmarks and propose LIGER (LeveragIng dense retrieval for GEnerative Retrieval), a hybrid model that combines the strengths of these two widely used methods. LIGER integrates sequential dense retrieval into generative retrieval, mitigating performance differences and enhancing cold-start item recommendation in the datasets evaluated. This hybrid approach provides insights into the trade-offs between these approaches and demonstrates improvements in efficiency and effectiveness for recommendation systems in small-scale benchmarks.
IVFeb 21, 2024
EXACT-Net:EHR-guided lung tumor auto-segmentation for non-small cell lung cancer radiotherapyHamed Hooshangnejad, Xue Feng, Gaofeng Huang et al.
Lung cancer is a devastating disease with the highest mortality rate among cancer types. Over 60% of non-small cell lung cancer (NSCLC) patients, which accounts for 87% of diagnoses, require radiation therapy. Rapid treatment initiation significantly increases the patient's survival rate and reduces the mortality rate. Accurate tumor segmentation is a critical step in the diagnosis and treatment of NSCLC. Manual segmentation is time and labor-consuming and causes delays in treatment initiation. Although many lung nodule detection methods, including deep learning-based models, have been proposed, there is still a long-standing problem of high false positives (FPs) with most of these methods. Here, we developed an electronic health record (EHR) guided lung tumor auto-segmentation called EXACT-Net (EHR-enhanced eXACtitude in Tumor segmentation), where the extracted information from EHRs using a pre-trained large language model (LLM), was used to remove the FPs and keep the TP nodules only. The auto-segmentation model was trained on NSCLC patients' computed tomography (CT), and the pre-trained LLM was used with the zero-shot learning approach. Our approach resulted in a 250% boost in successful nodule detection using the data from ten NSCLC patients treated in our institution.
CVJun 5, 2025
SIV-Bench: A Video Benchmark for Social Interaction Understanding and ReasoningFanqi Kong, Weiqin Zu, Xinyu Chen et al.
The rich and multifaceted nature of human social interaction, encompassing multimodal cues, unobservable relations and mental states, and dynamical behavior, presents a formidable challenge for artificial intelligence. To advance research in this area, we introduce SIV-Bench, a novel video benchmark for rigorously evaluating the capabilities of Multimodal Large Language Models (MLLMs) across Social Scene Understanding (SSU), Social State Reasoning (SSR), and Social Dynamics Prediction (SDP). SIV-Bench features 2,792 video clips and 8,792 meticulously generated question-answer pairs derived from a human-LLM collaborative pipeline. It is originally collected from TikTok and YouTube, covering a wide range of video genres, presentation styles, and linguistic and cultural backgrounds. It also includes a dedicated setup for analyzing the impact of different textual cues-original on-screen text, added dialogue, or no text. Our comprehensive experiments on leading MLLMs reveal that while models adeptly handle SSU, they significantly struggle with SSR and SDP, where Relation Inference (RI) is an acute bottleneck, as further examined in our analysis. Our study also confirms the critical role of transcribed dialogue in aiding comprehension of complex social interactions. By systematically identifying current MLLMs' strengths and limitations, SIV-Bench offers crucial insights to steer the development of more socially intelligent AI. The dataset and code are available at https://kfq20.github.io/sivbench/.
IRNov 3, 2024
MultiBalance: Multi-Objective Gradient Balancing in Industrial-Scale Multi-Task Recommendation SystemYun He, Xuxing Chen, Jiayi Xu et al.
In industrial recommendation systems, multi-task learning (learning multiple tasks simultaneously on a single model) is a predominant approach to save training/serving resources and improve recommendation performance via knowledge transfer between the joint learning tasks. However, multi-task learning often suffers from negative transfer: one or several tasks are less optimized than training them separately. To carefully balance the optimization, we propose a gradient balancing approach called MultiBalance, which is suitable for industrial-scale multi-task recommendation systems. It balances the per-task gradients to alleviate the negative transfer, while saving the huge cost for grid search or manual explorations for appropriate task weights. Moreover, compared with prior work that normally balance the per-task gradients of shared parameters, MultiBalance is more efficient since only requiring to access per-task gradients with respect to the shared feature representations. We conduct experiments on Meta's large-scale ads and feeds multi-task recommendation system, and observe that MultiBalance achieves significant gains (e.g., 0.738% improvement for normalized entropy (NE)) with neutral training cost in Queries Per Second (QPS), which is significantly more efficient than prior methods that balance per-task gradients of shared parameters with 70~80% QPS degradation.
IVMar 19, 2025
A Language Vision Model Approach for Automated Tumor Contouring in Radiation OncologyYi Luo, Hamed Hooshangnejad, Xue Feng et al.
Background: Lung cancer ranks as the leading cause of cancer-related mortality worldwide. The complexity of tumor delineation, crucial for radiation therapy, requires expertise often unavailable in resource-limited settings. Artificial Intelligence(AI), particularly with advancements in deep learning (DL) and natural language processing (NLP), offers potential solutions yet is challenged by high false positive rates. Purpose: The Oncology Contouring Copilot (OCC) system is developed to leverage oncologist expertise for precise tumor contouring using textual descriptions, aiming to increase the efficiency of oncological workflows by combining the strengths of AI with human oversight. Methods: Our OCC system initially identifies nodule candidates from CT scans. Employing Language Vision Models (LVMs) like GPT-4V, OCC then effectively reduces false positives with clinical descriptive texts, merging textual and visual data to automate tumor delineation, designed to elevate the quality of oncology care by incorporating knowledge from experienced domain experts. Results: Deployments of the OCC system resulted in a significant reduction in the false discovery rate by 35.0%, a 72.4% decrease in false positives per scan, and an F1-score of 0.652 across our dataset for unbiased evaluation. Conclusions: OCC represents a significant advance in oncology care, particularly through the use of the latest LVMs to improve contouring results by (1) streamlining oncology treatment workflows by optimizing tumor delineation, reducing manual processes; (2) offering a scalable and intuitive framework to reduce false positives in radiotherapy planning using LVMs; (3) introducing novel medical language vision prompt techniques to minimize LVMs hallucinations with ablation study, and (4) conducting a comparative analysis of LVMs, highlighting their potential in addressing medical language vision challenges.
CLDec 31, 2024
Are the Values of LLMs Structurally Aligned with Humans? A Causal PerspectiveYipeng Kang, Junqi Wang, Yexin Li et al.
As large language models (LLMs) become increasingly integrated into critical applications, aligning their behavior with human values presents significant challenges. Current methods, such as Reinforcement Learning from Human Feedback (RLHF), typically focus on a limited set of coarse-grained values and are resource-intensive. Moreover, the correlations between these values remain implicit, leading to unclear explanations for value-steering outcomes. Our work argues that a latent causal value graph underlies the value dimensions of LLMs and that, despite alignment training, this structure remains significantly different from human value systems. We leverage these causal value graphs to guide two lightweight value-steering methods: role-based prompting and sparse autoencoder (SAE) steering, effectively mitigating unexpected side effects. Furthermore, SAE provides a more fine-grained approach to value steering. Experiments on Gemma-2B-IT and Llama3-8B-IT demonstrate the effectiveness and controllability of our methods.
IRFeb 5, 2025
Beyond Self-Consistency: Loss-Balanced Perturbation-Based Regularization Improves Industrial-Scale Ads RankingIlqar Ramazanli, Hamid Eghbalzadeh, Xiaoyi Liu et al.
Perturbation-based regularization techniques address many challenges in industrial-scale large models, particularly with sparse labels, and emphasize consistency and invariance for perturbation in model predictions. One of the popular regularization techniques has been various forms of self-consistency, which involve making small modifications to input data while preserving contextual information and enforcing similar predictions through auxiliary loss functions. In this work, we explore the first successful application of perturbation-based regularization algorithms in large-scale ads ranking models, and further propose a novel regularization algorithm, namely, Loss-Balanced Small Perturbation Regularization (LSPR) that can be used in potentially any deep learning model. We have successfully demonstrate that both Self-Consistency Regularization approaches (SCR) and LSPR are scalable and can improve ads delivery systems. By conducting industrial-scale experiments, and numerical analysis, we additionally show that our proposed LSPR, performs consistently better compared to SCR, across various groups and signal availability setups. Finally, we report a successful application of the proposed LSPR in a billion-scale industrial ranking system, which to the best of our knowledge, is the first of its kind, and it is specially designed to address the various scalability challenges (e.g, various surfaces, geological locations, clients and so on) as we will mention in this paper.
OPTICSApr 9, 2024
Map Optical Properties to Subwavelength Structures Directly via a Diffusion ModelShijie Rao, Kaiyu Cui, Yidong Huang et al.
Subwavelength photonic structures and metamaterials provide revolutionary approaches for controlling light. The inverse design methods proposed for these subwavelength structures are vital to the development of new photonic devices. However, most of the existing inverse design methods cannot realize direct mapping from optical properties to photonic structures but instead rely on forward simulation methods to perform iterative optimization. In this work, we exploit the powerful generative abilities of artificial intelligence (AI) and propose a practical inverse design method based on latent diffusion models. Our method maps directly the optical properties to structures without the requirement of forward simulation and iterative optimization. Here, the given optical properties can work as "prompts" and guide the constructed model to correctly "draw" the required photonic structures. Experiments show that our direct mapping-based inverse design method can generate subwavelength photonic structures at high fidelity while following the given optical properties. This may change the method used for optical design and greatly accelerate the research on new photonic devices.
LGMar 8
Feed m Birds with One Scone: Accelerating Multi-task Gradient Balancing via Bi-level OptimizationXuxing Chen, Yun He, Jiayi Xu et al.
In machine learning, the goal of multi-task learning (MTL) is to optimize multiple objectives together. Recent works, for example, Multiple Gradient Descent Algorithm (MGDA) and its variants, show promising results with dynamically adjusted weights for different tasks to mitigate conflicts that may potentially degrade the performance on certain tasks. Despite the empirical success of MGDA-type methods, one major limitation of such methods is their computational inefficiency, as they require access to all task gradients. In this paper we introduce MARIGOLD, a unified algorithmic framework for efficiently solving MTL problems. Our method reveals that multi-task gradient balancing methods have a hierarchical structure, in which the model training and the gradient balancing are coupled during the whole optimization process and can be viewed as a bi-level optimization problem. Moreover, we showcase that the bi-level problem can be solved efficiently by leveraging zeroth-order method. Extensive experiments on both public datasets and industrial-scale datasets demonstrate the efficiency and superiority of our method.
CYOct 22, 2025
Social World Model-Augmented Mechanism Design Policy LearningXiaoyuan Zhang, Yizhe Huang, Chengdong Ma et al.
Designing adaptive mechanisms to align individual and collective interests remains a central challenge in artificial social intelligence. Existing methods often struggle with modeling heterogeneous agents possessing persistent latent traits (e.g., skills, preferences) and dealing with complex multi-agent system dynamics. These challenges are compounded by the critical need for high sample efficiency due to costly real-world interactions. World Models, by learning to predict environmental dynamics, offer a promising pathway to enhance mechanism design in heterogeneous and complex systems. In this paper, we introduce a novel method named SWM-AP (Social World Model-Augmented Mechanism Design Policy Learning), which learns a social world model hierarchically modeling agents' behavior to enhance mechanism design. Specifically, the social world model infers agents' traits from their interaction trajectories and learns a trait-based model to predict agents' responses to the deployed mechanisms. The mechanism design policy collects extensive training trajectories by interacting with the social world model, while concurrently inferring agents' traits online during real-world interactions to further boost policy learning efficiency. Experiments in diverse settings (tax policy design, team coordination, and facility location) demonstrate that SWM-AP outperforms established model-based and model-free RL baselines in cumulative rewards and sample efficiency.
LGOct 10, 2025
Cross-attention Secretly Performs Orthogonal Alignment in Recommendation ModelsHyunin Lee, Yong Zhang, Hoang Vu Nguyen et al.
Cross-domain sequential recommendation (CDSR) aims to align heterogeneous user behavior sequences collected from different domains. While cross-attention is widely used to enhance alignment and improve recommendation performance, its underlying mechanism is not fully understood. Most researchers interpret cross-attention as residual alignment, where the output is generated by removing redundant and preserving non-redundant information from the query input by referencing another domain data which is input key and value. Beyond the prevailing view, we introduce Orthogonal Alignment, a phenomenon in which cross-attention discovers novel information that is not present in the query input, and further argue that those two contrasting alignment mechanisms can co-exist in recommendation models We find that when the query input and output of cross-attention are orthogonal, model performance improves over 300 experiments. Notably, Orthogonal Alignment emerges naturally, without any explicit orthogonality constraints. Our key insight is that Orthogonal Alignment emerges naturally because it improves scaling law. We show that baselines additionally incorporating cross-attention module outperform parameter-matched baselines, achieving a superior accuracy-per-model parameter. We hope these findings offer new directions for parameter-efficient scaling in multi-modal research.
LGSep 30, 2025
CardioForest: An Explainable Ensemble Learning Model for Automatic Wide QRS Complex Tachycardia Diagnosis from ECGVaskar Chakma, Ju Xiaolin, Heling Cao et al.
This study aims to develop and evaluate an ensemble machine learning-based framework for the automatic detection of Wide QRS Complex Tachycardia (WCT) from ECG signals, emphasizing diagnostic accuracy and interpretability using Explainable AI. The proposed system integrates ensemble learning techniques, i.e., an optimized Random Forest known as CardioForest, and models like XGBoost and LightGBM. The models were trained and tested on ECG data from the publicly available MIMIC-IV dataset. The testing was carried out with the assistance of accuracy, balanced accuracy, precision, recall, F1 score, ROC-AUC, and error rate (RMSE, MAE) measures. In addition, SHAP (SHapley Additive exPlanations) was used to ascertain model explainability and clinical relevance. The CardioForest model performed best on all metrics, achieving a test accuracy of 95.19%, a balanced accuracy of 88.76%, a precision of 95.26%, a recall of 78.42%, and an ROC-AUC of 0.8886. SHAP analysis confirmed the model's ability to rank the most relevant ECG features, such as QRS duration, in accordance with clinical intuitions, thereby fostering trust and usability in clinical practice. The findings recognize CardioForest as an extremely dependable and interpretable WCT detection model. Being able to offer accurate predictions and transparency through explainability makes it a valuable tool to help cardiologists make timely and well-informed diagnoses, especially for high-stakes and emergency scenarios.
CVSep 26, 2025
Multimodal Slice Interaction Network Enhanced by Transfer Learning for Precise Segmentation of Internal Gross Tumor Volume in Lung Cancer PET/CT ImagingYi Luo, Yike Guo, Hamed Hooshangnejad et al.
Lung cancer remains the leading cause of cancerrelated deaths globally. Accurate delineation of internal gross tumor volume (IGTV) in PET/CT imaging is pivotal for optimal radiation therapy in mobile tumors such as lung cancer to account for tumor motion, yet is hindered by the limited availability of annotated IGTV datasets and attenuated PET signal intensity at tumor boundaries. In this study, we present a transfer learningbased methodology utilizing a multimodal interactive perception network with MAMBA, pre-trained on extensive gross tumor volume (GTV) datasets and subsequently fine-tuned on a private IGTV cohort. This cohort constitutes the PET/CT subset of the Lung-cancer Unified Cross-modal Imaging Dataset (LUCID). To further address the challenge of weak PET intensities in IGTV peripheral slices, we introduce a slice interaction module (SIM) within a 2.5D segmentation framework to effectively model inter-slice relationships. Our proposed module integrates channel and spatial attention branches with depthwise convolutions, enabling more robust learning of slice-to-slice dependencies and thereby improving overall segmentation performance. A comprehensive experimental evaluation demonstrates that our approach achieves a Dice of 0.609 on the private IGTV dataset, substantially surpassing the conventional baseline score of 0.385. This work highlights the potential of transfer learning, coupled with advanced multimodal techniques and a SIM to enhance the reliability and clinical relevance of IGTV segmentation for lung cancer radiation therapy planning.
AISep 25, 2025
ToMPO: Training LLM Strategic Decision Making from a Multi-Agent PerspectiveYiwen Zhang, Ziang Chen, Fanqi Kong et al.
Large Language Models (LLMs) have been used to make decisions in complex scenarios, where they need models to think deeply, reason logically, and decide wisely. Many existing studies focus solely on multi-round conversations in social tasks or simulated environments, neglecting the various types of decisions and their interdependence. Current reinforcement learning methods struggle to consider the strategies of others during training. To address these issues, we first define a strategic decision-making problem that includes two types of decisions and their temporal dependencies. Furthermore, we propose **T**heory **o**f **M**ind **P**olicy **O**ptimization **(ToMPO)** algorithm to optimize the perception of other individual strategies and the game situation trends. Compared to the Group Relative Policy Optimization (GRPO) algorithm, ToMPO enhances the LLM's strategic decision-making mainly by: 1) generating rollouts based on reasoning the strategies of other individuals, 2) estimating advantages at both the graph-level and sample-level, and 3) balancing global and partial rewards. The ToMPO algorithm outperforms the GRPO method by 35% in terms of model output compliance and cooperative outcomes. Additionally, when compared to models with parameter sizes 100 times larger, it shows an 18% improvement. This demonstrates the effectiveness of the ToMPO algorithm in enhancing the model's strategic decision-making capabilities.
CVJul 28, 2025
Endoscopic Depth Estimation Based on Deep Learning: A SurveyKe Niu, Zeyun Liu, Xue Feng et al.
Endoscopic depth estimation is a critical technology for improving the safety and precision of minimally invasive surgery. It has attracted considerable attention from researchers in medical imaging, computer vision, and robotics. Over the past decade, a large number of methods have been developed. Despite the existence of several related surveys, a comprehensive overview focusing on recent deep learning-based techniques is still limited. This paper endeavors to bridge this gap by systematically reviewing the state-of-the-art literature. Specifically, we provide a thorough survey of the field from three key perspectives: data, methods, and applications. Firstly, at the data level, we describe the acquisition process of publicly available datasets. Secondly, at the methodological level, we introduce both monocular and stereo deep learning-based approaches for endoscopic depth estimation. Thirdly, at the application level, we identify the specific challenges and corresponding solutions for the clinical implementation of depth estimation technology, situated within concrete clinical scenarios. Finally, we outline potential directions for future research, such as domain adaptation, real-time implementation, and the synergistic fusion of depth information with sensor technologies, thereby providing a valuable starting point for researchers to engage with and advance the field toward clinical translation.
LGMar 14, 2025
FedOSAA: Improving Federated Learning with One-Step Anderson AccelerationXue Feng, M. Paul Laiu, Thomas Strohmer
Federated learning (FL) is a distributed machine learning approach that enables multiple local clients and a central server to collaboratively train a model while keeping the data on their own devices. First-order methods, particularly those incorporating variance reduction techniques, are the most widely used FL algorithms due to their simple implementation and stable performance. However, these methods tend to be slow and require a large number of communication rounds to reach the global minimizer. We propose FedOSAA, a novel approach that preserves the simplicity of first-order methods while achieving the rapid convergence typically associated with second-order methods. Our approach applies one Anderson acceleration (AA) step following classical local updates based on first-order methods with variance reduction, such as FedSVRG and SCAFFOLD, during local training. This AA step is able to leverage curvature information from the history points and gives a new update that approximates the Newton-GMRES direction, thereby significantly improving the convergence. We establish a local linear convergence rate to the global minimizer of FedOSAA for smooth and strongly convex loss functions. Numerical comparisons show that FedOSAA substantially improves the communication and computation efficiency of the original first-order methods, achieving performance comparable to second-order methods like GIANT.
AIMar 6, 2025
ValuePilot: A Two-Phase Framework for Value-Driven Decision-MakingYitong Luo, Hou Hei Lam, Ziang Chen et al.
Despite recent advances in artificial intelligence (AI), it poses challenges to ensure personalized decision-making in tasks that are not considered in training datasets. To address this issue, we propose ValuePilot, a two-phase value-driven decision-making framework comprising a dataset generation toolkit DGT and a decision-making module DMM trained on the generated data. DGT is capable of generating scenarios based on value dimensions and closely mirroring real-world tasks, with automated filtering techniques and human curation to ensure the validity of the dataset. In the generated dataset, DMM learns to recognize the inherent values of scenarios, computes action feasibility and navigates the trade-offs between multiple value dimensions to make personalized decisions. Extensive experiments demonstrate that, given human value preferences, our DMM most closely aligns with human decisions, outperforming Claude-3.5-Sonnet, Gemini-2-flash, Llama-3.1-405b and GPT-4o. This research is a preliminary exploration of value-driven decision-making. We hope it will stimulate interest in value-driven decision-making and personalized decision-making within the community.
LGFeb 5, 2025
A Unified Knowledge-Distillation and Semi-Supervised Learning Framework to Improve Industrial Ads Delivery SystemsHamid Eghbalzadeh, Yang Wang, Rui Li et al.
Industrial ads ranking systems conventionally rely on labeled impression data, which leads to challenges such as overfitting, slower incremental gain from model scaling, and biases due to discrepancies between training and serving data. To overcome these issues, we propose a Unified framework for Knowledge-Distillation and Semi-supervised Learning (UKDSL) for ads ranking, empowering the training of models on a significantly larger and more diverse datasets, thereby reducing overfitting and mitigating training-serving data discrepancies. We provide detailed formal analysis and numerical simulations on the inherent miscalibration and prediction bias of multi-stage ranking systems, and show empirical evidence of the proposed framework's capability to mitigate those. Compared to prior work, UKDSL can enable models to learn from a much larger set of unlabeled data, hence, improving the performance while being computationally efficient. Finally, we report the successful deployment of UKDSL in an industrial setting across various ranking models, serving users at multi-billion scale, across various surfaces, geological locations, clients, and optimize for various events, which to the best of our knowledge is the first of its kind in terms of the scale and efficiency at which it operates.
LGJan 23, 2025
Personalized Interpolation: Achieving Efficient Conversion Estimation with Flexible Optimization WindowsXin Zhang, Weiliang Li, Rui Li et al.
Optimizing conversions is crucial in modern online advertising systems, enabling advertisers to deliver relevant products to users and drive business outcomes. However, accurately predicting conversion events remains challenging due to variable time delays between user interactions (e.g., impressions or clicks) and the actual conversions. These delays vary substantially across advertisers and products, necessitating flexible optimization windows tailored to specific conversion behaviors. To address this, we propose a novel \textit{Personalized Interpolation} method that extends existing models based on fixed conversion windows to support flexible advertiser-specific optimization windows. Our method enables accurate conversion estimation across diverse delay distributions without increasing system complexity. We evaluate the effectiveness of the proposed approach through extensive experiments using a real-world ads conversion model. Our results show that this method achieves both high prediction accuracy and improved efficiency compared to existing solutions. This study demonstrates the potential of our Personalized Interpolation method to improve conversion optimization and support a wider range of advertising strategies in large-scale online advertising systems.
AIJun 12, 2024
Efficient Adaptation in Mixed-Motive Environments via Hierarchical Opponent Modeling and PlanningYizhe Huang, Anji Liu, Fanqi Kong et al.
Despite the recent successes of multi-agent reinforcement learning (MARL) algorithms, efficiently adapting to co-players in mixed-motive environments remains a significant challenge. One feasible approach is to hierarchically model co-players' behavior based on inferring their characteristics. However, these methods often encounter difficulties in efficient reasoning and utilization of inferred information. To address these issues, we propose Hierarchical Opponent modeling and Planning (HOP), a novel multi-agent decision-making algorithm that enables few-shot adaptation to unseen policies in mixed-motive environments. HOP is hierarchically composed of two modules: an opponent modeling module that infers others' goals and learns corresponding goal-conditioned policies, and a planning module that employs Monte Carlo Tree Search (MCTS) to identify the best response. Our approach improves efficiency by updating beliefs about others' goals both across and within episodes and by using information from the opponent modeling module to guide planning. Experimental results demonstrate that in mixed-motive environments, HOP exhibits superior few-shot adaptation capabilities when interacting with various unseen agents, and excels in self-play scenarios. Furthermore, the emergence of social intelligence during our experiments underscores the potential of our approach in complex multi-agent environments.
IVAug 9, 2021
Deep Learning methods for automatic evaluation of delayed enhancement-MRI. The results of the EMIDEC challengeAlain Lalande, Zhihao Chen, Thibaut Pommier et al.
A key factor for assessing the state of the heart after myocardial infarction (MI) is to measure whether the myocardium segment is viable after reperfusion or revascularization therapy. Delayed enhancement-MRI or DE-MRI, which is performed several minutes after injection of the contrast agent, provides high contrast between viable and nonviable myocardium and is therefore a method of choice to evaluate the extent of MI. To automatically assess myocardial status, the results of the EMIDEC challenge that focused on this task are presented in this paper. The challenge's main objectives were twofold. First, to evaluate if deep learning methods can distinguish between normal and pathological cases. Second, to automatically calculate the extent of myocardial infarction. The publicly available database consists of 150 exams divided into 50 cases with normal MRI after injection of a contrast agent and 100 cases with myocardial infarction (and then with a hyperenhanced area on DE-MRI), whatever their inclusion in the cardiac emergency department. Along with MRI, clinical characteristics are also provided. The obtained results issued from several works show that the automatic classification of an exam is a reachable task (the best method providing an accuracy of 0.92), and the automatic segmentation of the myocardium is possible. However, the segmentation of the diseased area needs to be improved, mainly due to the small size of these areas and the lack of contrast with the surrounding structures.
IVJul 4, 2020
Multi-Site Infant Brain Segmentation Algorithms: The iSeg-2019 ChallengeYue Sun, Kun Gao, Zhengwang Wu et al.
To better understand early brain growth patterns in health and disorder, it is critical to accurately segment infant brain magnetic resonance (MR) images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF). Deep learning-based methods have achieved state-of-the-art performance; however, one of major limitations is that the learning-based methods may suffer from the multi-site issue, that is, the models trained on a dataset from one site may not be applicable to the datasets acquired from other sites with different imaging protocols/scanners. To promote methodological development in the community, iSeg-2019 challenge (http://iseg2019.web.unc.edu) provides a set of 6-month infant subjects from multiple sites with different protocols/scanners for the participating methods. Training/validation subjects are from UNC (MAP) and testing subjects are from UNC/UMN (BCP), Stanford University, and Emory University. By the time of writing, there are 30 automatic segmentation methods participating in iSeg-2019. We review the 8 top-ranked teams by detailing their pipelines/implementations, presenting experimental results and evaluating performance in terms of the whole brain, regions of interest, and gyral landmark curves. We also discuss their limitations and possible future directions for the multi-site issue. We hope that the multi-site dataset in iSeg-2019 and this review article will attract more researchers on the multi-site issue.
MLJun 19, 2020
Feature Interaction Interpretability: A Case for Explaining Ad-Recommendation Systems via Neural Interaction DetectionMichael Tsang, Dehua Cheng, Hanpeng Liu et al.
Recommendation is a prevalent application of machine learning that affects many users; therefore, it is important for recommender models to be accurate and interpretable. In this work, we propose a method to both interpret and augment the predictions of black-box recommender systems. In particular, we propose to interpret feature interactions from a source recommender model and explicitly encode these interactions in a target recommender model, where both source and target models are black-boxes. By not assuming the structure of the recommender system, our approach can be used in general settings. In our experiments, we focus on a prominent use of machine learning recommendation: ad-click prediction. We found that our interaction interpretations are both informative and predictive, e.g., significantly outperforming existing recommender models. What's more, the same approach to interpret interactions can provide new insights into domains even beyond recommendation, such as text and image classification.
CVOct 19, 2019
MixModule: Mixed CNN Kernel Module for Medical Image SegmentationHenry H. Yu, Xue Feng, Hao Sun et al.
Convolutional neural networks (CNNs) have been successfully applied to medical image classification, segmentation, and related tasks. Among the many CNNs architectures, U-Net and its improved versions based are widely used and achieve state-of-the-art performance these years. These improved architectures focus on structural improvements and the size of the convolution kernel is generally fixed. In this paper, we propose a module that combines the benefits of multiple kernel sizes and we apply the proposed module to U-Net and its variants. We test our module on three segmentation benchmark datasets and experimental results show significant improvement.
CVMar 6, 2019
Prostate Segmentation from 3D MRI Using a Two-Stage Model and Variable-Input Based Uncertainty MeasureHuitong Pan, Yushan Feng, Quan Chen et al.
This paper proposes a two-stage segmentation model, variable-input based uncertainty measures and an uncertainty-guided post-processing method for prostate segmentation on 3D magnetic resonance images (MRI). The two-stage model was based on 3D dilated U-Nets with the first stage to localize the prostate and the second stage to obtain an accurate segmentation from cropped images. For data augmentation, we proposed the variable-input method which crops the region of interest with additional random variations. Similar to other deep learning models, the proposed model also faced the challenge of suboptimal performance in certain testing cases due to varied training and testing image characteristics. Therefore, it is valuable to evaluate the confidence and performance of the network using uncertainty measures, which are often calculated from the probability maps or their standard deviations with multiple model outputs for the same testing case. However, few studies have quantitatively compared different methods of uncertainty calculation. Furthermore, unlike the commonly used Bayesian dropout during testing, we developed uncertainty measures based on the variable input images at the second stage and evaluated its performance by calculating the correlation with ground-truth-based performance metrics, such as Dice score. For performance estimation, we predicted Dice scores and Hausdorff distance with the most correlated uncertainty measure. For post-processing, we performed Gaussian filter on the underperformed slices to improve segmentation quality. Using PROMISE-12 data, we demonstrated the robustness of the two-stage model and showed high correlation of the proposed variable-input based uncertainty measures with GT-based performance. The uncertainty-guided post-processing method significantly improved label smoothness.
CVDec 3, 2018
Brain Tumor Segmentation using an Ensemble of 3D U-Nets and Overall Survival Prediction using Radiomic FeaturesXue Feng, Nicholas Tustison, Craig Meyer
Accurate segmentation of different sub-regions of gliomas including peritumoral edema, necrotic core, enhancing and non-enhancing tumor core from multimodal MRI scans has important clinical relevance in diagnosis, prognosis and treatment of brain tumors. However, due to the highly heterogeneous appearance and shape, segmentation of the sub-regions is very challenging. Recent development using deep learning models has proved its effectiveness in the past several brain segmentation challenges as well as other semantic and medical image segmentation problems. Most models in brain tumor segmentation use a 2D/3D patch to predict the class label for the center voxel and variant patch sizes and scales are used to improve the model performance. However, it has low computation efficiency and also has limited receptive field. U-Net is a widely used network structure for end-to-end segmentation and can be used on the entire image or extracted patches to provide classification labels over the entire input voxels so that it is more efficient and expect to yield better performance with larger input size. Furthermore, instead of picking the best network structure, an ensemble of multiple models, trained on different dataset or different hyper-parameters, can generally improve the segmentation performance. In this study we propose to use an ensemble of 3D U-Nets with different hyper-parameters for brain tumor segmentation. Preliminary results showed effectiveness of this model. In addition, we developed a linear model for survival prediction using extracted imaging and non-imaging features, which, despite the simplicity, can effectively reduce overfitting and regression errors.
CVNov 19, 2018
A Self-Adaptive Network For Multiple Sclerosis Lesion Segmentation From Multi-Contrast MRI With Various Imaging ProtocolsYushan Feng, Huitong Pan, Craig Meyer et al.
Deep neural networks (DNN) have shown promises in the lesion segmentation of multiple sclerosis (MS) from multicontrast MRI including T1, T2, proton density (PD) and FLAIR sequences. However, one challenge in deploying such networks into clinical practice is the variability of imaging protocols, which often differ from the training dataset as certain MRI sequences may be unavailable or unusable. Therefore, trained networks need to adapt to practical situations when imaging protocols are different in deployment. In this paper, we propose a DNN-based MS lesion segmentation framework with a novel technique called sequence dropout which can adapt to various combinations of input MRI sequences during deployment and achieve the maximal possible performance from the given input. In addition, with this framework, we studied the quantitative impact of each MRI sequence on the MS lesion segmentation task without training separate networks. Experiments were performed using the IEEE ISBI 2015 Longitudinal MS Lesion Challenge dataset and our method is currently ranked 2nd with a Dice similarity coefficient of 0.684. Furthermore, we showed our network achieved the maximal possible performance when one sequence is unavailable during deployment by comparing with separate networks trained on the corresponding input MRI sequences. In particular, we discovered T1 and PD have minor impact on segmentation performance while FLAIR is the predominant sequence. Experiments with multiple missing sequences were also performed and showed the robustness of our network.
CVNov 5, 2018
Identifying the Best Machine Learning Algorithms for Brain Tumor Segmentation, Progression Assessment, and Overall Survival Prediction in the BRATS ChallengeSpyridon Bakas, Mauricio Reyes, Andras Jakab et al.
Gliomas are the most common primary brain malignancies, with different degrees of aggressiveness, variable prognosis and various heterogeneous histologic sub-regions, i.e., peritumoral edematous/invaded tissue, necrotic core, active and non-enhancing core. This intrinsic heterogeneity is also portrayed in their radio-phenotype, as their sub-regions are depicted by varying intensity profiles disseminated across multi-parametric magnetic resonance imaging (mpMRI) scans, reflecting varying biological properties. Their heterogeneous shape, extent, and location are some of the factors that make these tumors difficult to resect, and in some cases inoperable. The amount of resected tumor is a factor also considered in longitudinal scans, when evaluating the apparent tumor for potential diagnosis of progression. Furthermore, there is mounting evidence that accurate segmentation of the various tumor sub-regions can offer the basis for quantitative image analysis towards prediction of patient overall survival. This study assesses the state-of-the-art machine learning (ML) methods used for brain tumor image analysis in mpMRI scans, during the last seven instances of the International Brain Tumor Segmentation (BraTS) challenge, i.e., 2012-2018. Specifically, we focus on i) evaluating segmentations of the various glioma sub-regions in pre-operative mpMRI scans, ii) assessing potential tumor progression by virtue of longitudinal growth of tumor sub-regions, beyond use of the RECIST/RANO criteria, and iii) predicting the overall survival from pre-operative mpMRI scans of patients that underwent gross total resection. Finally, we investigate the challenge of identifying the best ML algorithms for each of these tasks, considering that apart from being diverse on each instance of the challenge, the multi-institutional mpMRI BraTS dataset has also been a continuously evolving/growing dataset.