Hui Qu

DeepSeek-AI, Daya Guo, Dejian Yang et al. · stanford, tsinghua

We introduce our first-generation reasoning models, DeepSeek-R1-Zero and DeepSeek-R1. DeepSeek-R1-Zero, a model trained via large-scale reinforcement learning (RL) without supervised fine-tuning (SFT) as a preliminary step, demonstrates remarkable reasoning capabilities. Through RL, DeepSeek-R1-Zero naturally emerges with numerous powerful and intriguing reasoning behaviors. However, it encounters challenges such as poor readability, and language mixing. To address these issues and further enhance reasoning performance, we introduce DeepSeek-R1, which incorporates multi-stage training and cold-start data before RL. DeepSeek-R1 achieves performance comparable to OpenAI-o1-1217 on reasoning tasks. To support the research community, we open-source DeepSeek-R1-Zero, DeepSeek-R1, and six dense models (1.5B, 7B, 8B, 14B, 32B, 70B) distilled from DeepSeek-R1 based on Qwen and Llama.

DeepSeek-AI, Aixin Liu, Bei Feng et al. · pku

We present DeepSeek-V2, a strong Mixture-of-Experts (MoE) language model characterized by economical training and efficient inference. It comprises 236B total parameters, of which 21B are activated for each token, and supports a context length of 128K tokens. DeepSeek-V2 adopts innovative architectures including Multi-head Latent Attention (MLA) and DeepSeekMoE. MLA guarantees efficient inference through significantly compressing the Key-Value (KV) cache into a latent vector, while DeepSeekMoE enables training strong models at an economical cost through sparse computation. Compared with DeepSeek 67B, DeepSeek-V2 achieves significantly stronger performance, and meanwhile saves 42.5% of training costs, reduces the KV cache by 93.3%, and boosts the maximum generation throughput to 5.76 times. We pretrain DeepSeek-V2 on a high-quality and multi-source corpus consisting of 8.1T tokens, and further perform Supervised Fine-Tuning (SFT) and Reinforcement Learning (RL) to fully unlock its potential. Evaluation results show that, even with only 21B activated parameters, DeepSeek-V2 and its chat versions still achieve top-tier performance among open-source models.

DeepSeek-AI, Xiao Bi, Deli Chen et al. · microsoft-research, pku

The rapid development of open-source large language models (LLMs) has been truly remarkable. However, the scaling law described in previous literature presents varying conclusions, which casts a dark cloud over scaling LLMs. We delve into the study of scaling laws and present our distinctive findings that facilitate scaling of large scale models in two commonly used open-source configurations, 7B and 67B. Guided by the scaling laws, we introduce DeepSeek LLM, a project dedicated to advancing open-source language models with a long-term perspective. To support the pre-training phase, we have developed a dataset that currently consists of 2 trillion tokens and is continuously expanding. We further conduct supervised fine-tuning (SFT) and Direct Preference Optimization (DPO) on DeepSeek LLM Base models, resulting in the creation of DeepSeek Chat models. Our evaluation results demonstrate that DeepSeek LLM 67B surpasses LLaMA-2 70B on various benchmarks, particularly in the domains of code, mathematics, and reasoning. Furthermore, open-ended evaluations reveal that DeepSeek LLM 67B Chat exhibits superior performance compared to GPT-3.5.

Wei An, Xiao Bi, Guanting Chen et al.

The rapid progress in Deep Learning (DL) and Large Language Models (LLMs) has exponentially increased demands of computational power and bandwidth. This, combined with the high costs of faster computing chips and interconnects, has significantly inflated High Performance Computing (HPC) construction costs. To address these challenges, we introduce the Fire-Flyer AI-HPC architecture, a synergistic hardware-software co-design framework and its best practices. For DL training, we deployed the Fire-Flyer 2 with 10,000 PCIe A100 GPUs, achieved performance approximating the DGX-A100 while reducing costs by half and energy consumption by 40%. We specifically engineered HFReduce to accelerate allreduce communication and implemented numerous measures to keep our Computation-Storage Integrated Network congestion-free. Through our software stack, including HaiScale, 3FS, and HAI-Platform, we achieved substantial scalability by overlapping computation and communication. Our system-oriented experience from DL training provides valuable insights to drive future advancements in AI-HPC.

DeepSeek-AI, Aixin Liu, Aoxue Mei et al.

We introduce DeepSeek-V3.2, a model that harmonizes high computational efficiency with superior reasoning and agent performance. The key technical breakthroughs of DeepSeek-V3.2 are as follows: (1) DeepSeek Sparse Attention (DSA): We introduce DSA, an efficient attention mechanism that substantially reduces computational complexity while preserving model performance in long-context scenarios. (2) Scalable Reinforcement Learning Framework: By implementing a robust reinforcement learning protocol and scaling post-training compute, DeepSeek-V3.2 performs comparably to GPT-5. Notably, our high-compute variant, DeepSeek-V3.2-Speciale, surpasses GPT-5 and exhibits reasoning proficiency on par with Gemini-3.0-Pro, achieving gold-medal performance in both the 2025 International Mathematical Olympiad (IMO) and the International Olympiad in Informatics (IOI). (3) Large-Scale Agentic Task Synthesis Pipeline: To integrate reasoning into tool-use scenarios, we developed a novel synthesis pipeline that systematically generates training data at scale. This methodology facilitates scalable agentic post-training, yielding substantial improvements in generalization and instruction-following robustness within complex, interactive environments.

DeepSeek-AI, Aixin Liu, Bei Feng et al. · stanford, tsinghua

We present DeepSeek-V3, a strong Mixture-of-Experts (MoE) language model with 671B total parameters with 37B activated for each token. To achieve efficient inference and cost-effective training, DeepSeek-V3 adopts Multi-head Latent Attention (MLA) and DeepSeekMoE architectures, which were thoroughly validated in DeepSeek-V2. Furthermore, DeepSeek-V3 pioneers an auxiliary-loss-free strategy for load balancing and sets a multi-token prediction training objective for stronger performance. We pre-train DeepSeek-V3 on 14.8 trillion diverse and high-quality tokens, followed by Supervised Fine-Tuning and Reinforcement Learning stages to fully harness its capabilities. Comprehensive evaluations reveal that DeepSeek-V3 outperforms other open-source models and achieves performance comparable to leading closed-source models. Despite its excellent performance, DeepSeek-V3 requires only 2.788M H800 GPU hours for its full training. In addition, its training process is remarkably stable. Throughout the entire training process, we did not experience any irrecoverable loss spikes or perform any rollbacks. The model checkpoints are available at https://github.com/deepseek-ai/DeepSeek-V3.

Jingru Yi, Pengxiang Wu, Hui Tang et al.

Instance segmentation is of great importance for many biological applications, such as study of neural cell interactions, plant phenotyping, and quantitatively measuring how cells react to drug treatment. In this paper, we propose a novel box-based instance segmentation method. Box-based instance segmentation methods capture objects via bounding boxes and then perform individual segmentation within each bounding box region. However, existing methods can hardly differentiate the target from its neighboring objects within the same bounding box region due to their similar textures and low-contrast boundaries. To deal with this problem, in this paper, we propose an object-guided instance segmentation method. Our method first detects the center points of the objects, from which the bounding box parameters are then predicted. To perform segmentation, an object-guided coarse-to-fine segmentation branch is built along with the detection branch. The segmentation branch reuses the object features as guidance to separate target object from the neighboring ones within the same bounding box region. To further improve the segmentation quality, we design an auxiliary feature refinement module that densely samples and refines point-wise features in the boundary regions. Experimental results on three biological image datasets demonstrate the advantages of our method. The code will be available at https://github.com/yijingru/ObjGuided-Instance-Segmentation.

Ananya Jana, Hui Qu, Carlos D. Minacapelli et al.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver diseases (CLD) which can progress to liver cancer. The severity and treatment of NAFLD is determined by NAFLD Activity Scores (NAS)and liver fibrosis stage, which are usually obtained from liver biopsy. However, biopsy is invasive in nature and involves risk of procedural complications. Current methods to predict the fibrosis and NAS scores from noninvasive CT images rely heavily on either a large annotated dataset or transfer learning using pretrained networks. However, the availability of a large annotated dataset cannot be always ensured andthere can be domain shifts when using transfer learning. In this work, we propose a self-supervised learning method to address both problems. As the NAFLD causes changes in the liver texture, we also propose to use texture encoded inputs to improve the performance of the model. Given a relatively small dataset with 30 patients, we employ a self-supervised network which achieves better performance than a network trained via transfer learning. The code is publicly available at https://github.com/ananyajana/fibrosis_code.

Jingru Yi, Pengxiang Wu, Bo Liu et al.

Oriented object detection in aerial images is a challenging task as the objects in aerial images are displayed in arbitrary directions and are usually densely packed. Current oriented object detection methods mainly rely on two-stage anchor-based detectors. However, the anchor-based detectors typically suffer from a severe imbalance issue between the positive and negative anchor boxes. To address this issue, in this work we extend the horizontal keypoint-based object detector to the oriented object detection task. In particular, we first detect the center keypoints of the objects, based on which we then regress the box boundary-aware vectors (BBAVectors) to capture the oriented bounding boxes. The box boundary-aware vectors are distributed in the four quadrants of a Cartesian coordinate system for all arbitrarily oriented objects. To relieve the difficulty of learning the vectors in the corner cases, we further classify the oriented bounding boxes into horizontal and rotational bounding boxes. In the experiment, we show that learning the box boundary-aware vectors is superior to directly predicting the width, height, and angle of an oriented bounding box, as adopted in the baseline method. Besides, the proposed method competes favorably with state-of-the-art methods. Code is available at https://github.com/yijingru/BBAVectors-Oriented-Object-Detection.

Jingru Yi, Pengxiang Wu, Qiaoying Huang et al.

Adolescent idiopathic scoliosis (AIS) is a lifetime disease that arises in children. Accurate estimation of Cobb angles of the scoliosis is essential for clinicians to make diagnosis and treatment decisions. The Cobb angles are measured according to the vertebrae landmarks. Existing regression-based methods for the vertebra landmark detection typically suffer from large dense mapping parameters and inaccurate landmark localization. The segmentation-based methods tend to predict connected or corrupted vertebra masks. In this paper, we propose a novel vertebra-focused landmark detection method. Our model first localizes the vertebra centers, based on which it then traces the four corner landmarks of the vertebra through the learned corner offset. In this way, our method is able to keep the order of the landmarks. The comparison results demonstrate the merits of our method in both Cobb angle measurement and landmark detection on low-contrast and ambiguous X-ray images. Code is available at: \url{https://github.com/yijingru/Vertebra-Landmark-Detection}.

Jingru Yi, Pengxiang Wu, Qiaoying Huang et al.

Most existing methods handle cell instance segmentation problems directly without relying on additional detection boxes. These methods generally fails to separate touching cells due to the lack of global understanding of the objects. In contrast, box-based instance segmentation solves this problem by combining object detection with segmentation. However, existing methods typically utilize anchor box-based detectors, which would lead to inferior instance segmentation performance due to the class imbalance issue. In this paper, we propose a new box-based cell instance segmentation method. In particular, we first detect the five pre-defined points of a cell via keypoints detection. Then we group these points according to a keypoint graph and subsequently extract the bounding box for each cell. Finally, cell segmentation is performed on feature maps within the bounding boxes. We validate our method on two cell datasets with distinct object shapes, and empirically demonstrate the superiority of our method compared to other instance segmentation techniques. Code is available at: https://github.com/yijingru/KG_Instance_Segmentation.

Chieh-Yun Chen, Zhonghao Wang, Qi Chen et al.

Reinforcement learning from human feedback (RLHF) with reward models has advanced alignment of generative models to human aesthetic and perceptual preferences. However, jointly optimizing multiple rewards often incurs an alignment tax, improving one dimension while degrading others. To address this, we introduce two complementary methods: MapReduce LoRA and Reward-aware Token Embedding (RaTE). MapReduce LoRA trains preference-specific LoRA experts in parallel and iteratively merges them to refine a shared base model; RaTE learns reward-specific token embeddings that compose at inference for flexible preference control. Experiments on Text-to-Image generation (Stable Diffusion 3.5 Medium and FLUX.1-dev) show improvements of 36.1%, 4.6%, and 55.7%, and 32.7%, 4.3%, and 67.1% on GenEval, PickScore, and OCR, respectively. On Text-to-Video generation (HunyuanVideo), visual and motion quality improve by 48.1% and 90.0%, respectively. On the language task, Helpful Assistant, with Llama-2 7B, helpful and harmless improve by 43.4% and 136.7%, respectively. Our framework sets a new state-of-the-art multi-preference alignment recipe across modalities.

Yi-Ting Hsiao, Siavash Khodadadeh, Kevin Duarte et al.

Diffusion models have shown tremendous results in image generation. However, due to the iterative nature of the diffusion process and its reliance on classifier-free guidance, inference times are slow. In this paper, we propose a new distillation approach for guided diffusion models in which an external lightweight guide model is trained while the original text-to-image model remains frozen. We show that our method reduces the inference computation of classifier-free guided latent-space diffusion models by almost half, and only requires 1\% trainable parameters of the base model. Furthermore, once trained, our guide model can be applied to various fine-tuned, domain-specific versions of the base diffusion model without the need for additional training: this "plug-and-play" functionality drastically improves inference computation while maintaining the visual fidelity of generated images. Empirically, we show that our approach is able to produce visually appealing results and achieve a comparable FID score to the teacher with as few as 8 to 16 steps.

Qi Chang, Hui Qu, Zhennan Yan et al.

Multi-modality images have been widely used and provide comprehensive information for medical image analysis. However, acquiring all modalities among all institutes is costly and often impossible in clinical settings. To leverage more comprehensive multi-modality information, we propose a privacy secured decentralized multi-modality adaptive learning architecture named ModalityBank. Our method could learn a set of effective domain-specific modulation parameters plugged into a common domain-agnostic network. We demonstrate by switching different sets of configurations, the generator could output high-quality images for a specific modality. Our method could also complete the missing modalities across all data centers, thus could be used for modality completion purposes. The downstream task trained from the synthesized multi-modality samples could achieve higher performance than learning from one real data center and achieve close-to-real performance compare with all real images.

Yikai Zhang, Hui Qu, Qi Chang et al.

Recently, Generative Adversarial Networks (GANs) have demonstrated their potential in federated learning, i.e., learning a centralized model from data privately hosted by multiple sites. A federatedGAN jointly trains a centralized generator and multiple private discriminators hosted at different sites. A major theoretical challenge for the federated GAN is the heterogeneity of the local data distributions. Traditional approaches cannot guarantee to learn the target distribution, which isa mixture of the highly different local distributions. This paper tackles this theoretical challenge, and for the first time, provides a provably correct framework for federated GAN. We propose a new approach called Universal Aggregation, which simulates a centralized discriminator via carefully aggregating the mixture of all private discriminators. We prove that a generator trained with this simulated centralized discriminator can learn the desired target distribution. Through synthetic and real datasets, we show that our method can learn the mixture of largely different distributions where existing federated GAN methods fail.

Qi Chang, Zhennan Yan, Lohendran Baskaran et al.

As deep learning technologies advance, increasingly more data is necessary to generate general and robust models for various tasks. In the medical domain, however, large-scale and multi-parties data training and analyses are infeasible due to the privacy and data security concerns. In this paper, we propose an extendable and elastic learning framework to preserve privacy and security while enabling collaborative learning with efficient communication. The proposed framework is named distributed Asynchronized Discriminator Generative Adversarial Networks (AsynDGAN), which consists of a centralized generator and multiple distributed discriminators. The advantages of our proposed framework are five-fold: 1) the central generator could learn the real data distribution from multiple datasets implicitly without sharing the image data; 2) the framework is applicable for single-modality or multi-modality data; 3) the learned generator can be used to synthesize samples for down-stream learning tasks to achieve close-to-real performance as using actual samples collected from multiple data centers; 4) the synthetic samples can also be used to augment data or complete missing modalities for one single data center; 5) the learning process is more efficient and requires lower bandwidth than other distributed deep learning methods.

Ananya Jana, Hui Qu, Puru Rattan et al.

Non-Alcoholic Fatty Liver Disease (NAFLD) is becoming increasingly prevalent in the world population. Without diagnosis at the right time, NAFLD can lead to non-alcoholic steatohepatitis (NASH) and subsequent liver damage. The diagnosis and treatment of NAFLD depend on the NAFLD activity score (NAS) and the liver fibrosis stage, which are usually evaluated from liver biopsies by pathologists. In this work, we propose a novel method to automatically predict NAS score and fibrosis stage from CT data that is non-invasive and inexpensive to obtain compared with liver biopsy. We also present a method to combine the information from CT and H\&E stained pathology data to improve the performance of NAS score and fibrosis stage prediction, when both types of data are available. This is of great value to assist the pathologists in computer-aided diagnosis process. Experiments on a 30-patient dataset illustrate the effectiveness of our method.

Qiaoying Huang, Dong Yang, Yikun Xian et al.

The accurate reconstruction of under-sampled magnetic resonance imaging (MRI) data using modern deep learning technology, requires significant effort to design the necessary complex neural network architectures. The cascaded network architecture for MRI reconstruction has been widely used, while it suffers from the "vanishing gradient" problem when the network becomes deep. In addition, homogeneous architecture degrades the representation capacity of the network. In this work, we present an enhanced MRI reconstruction network using a residual in residual basic block. For each cell in the basic block, we use the differentiable neural architecture search (NAS) technique to automatically choose the optimal operation among eight variants of the dense block. This new heterogeneous network is evaluated on two publicly available datasets and outperforms all current state-of-the-art methods, which demonstrates the effectiveness of our proposed method.

Hui Qu, Yikai Zhang, Qi Chang et al.

In this work, we propose a method for training distributed GAN with sequential temporary discriminators. Our proposed method tackles the challenge of training GAN in the federated learning manner: How to update the generator with a flow of temporary discriminators? We apply our proposed method to learn a self-adaptive generator with a series of local discriminators from multiple data centers. We show our design of loss function indeed learns the correct distribution with provable guarantees. The empirical experiments show that our approach is capable of generating synthetic data which is practical for real-world applications such as training a segmentation model.

Hui Qu, Pengxiang Wu, Qiaoying Huang et al.

Nuclei segmentation is a fundamental task in histopathology image analysis. Typically, such segmentation tasks require significant effort to manually generate accurate pixel-wise annotations for fully supervised training. To alleviate such tedious and manual effort, in this paper we propose a novel weakly supervised segmentation framework based on partial points annotation, i.e., only a small portion of nuclei locations in each image are labeled. The framework consists of two learning stages. In the first stage, we design a semi-supervised strategy to learn a detection model from partially labeled nuclei locations. Specifically, an extended Gaussian mask is designed to train an initial model with partially labeled data. Then, selftraining with background propagation is proposed to make use of the unlabeled regions to boost nuclei detection and suppress false positives. In the second stage, a segmentation model is trained from the detected nuclei locations in a weakly-supervised fashion. Two types of coarse labels with complementary information are derived from the detected points and are then utilized to train a deep neural network. The fully-connected conditional random field loss is utilized in training to further refine the model without introducing extra computational complexity during inference. The proposed method is extensively evaluated on two nuclei segmentation datasets. The experimental results demonstrate that our method can achieve competitive performance compared to the fully supervised counterpart and the state-of-the-art methods while requiring significantly less annotation effort.

Qi Chang, Hui Qu, Yikai Zhang et al.

In this paper, we propose a data privacy-preserving and communication efficient distributed GAN learning framework named Distributed Asynchronized Discriminator GAN (AsynDGAN). Our proposed framework aims to train a central generator learns from distributed discriminator, and use the generated synthetic image solely to train the segmentation model.We validate the proposed framework on the application of health entities learning problem which is known to be privacy sensitive. Our experiments show that our approach: 1) could learn the real image's distribution from multiple datasets without sharing the patient's raw data. 2) is more efficient and requires lower bandwidth than other distributed deep learning methods. 3) achieves higher performance compared to the model trained by one real dataset, and almost the same performance compared to the model trained by all real datasets. 4) has provable guarantees that the generator could learn the distributed distribution in an all important fashion thus is unbiased.

Qiaoying Huang, Dong Yang, Pengxiang Wu et al.

We consider an MRI reconstruction problem with input of k-space data at a very low undersampled rate. This can practically benefit patient due to reduced time of MRI scan, but it is also challenging since quality of reconstruction may be compromised. Currently, deep learning based methods dominate MRI reconstruction over traditional approaches such as Compressed Sensing, but they rarely show satisfactory performance in the case of low undersampled k-space data. One explanation is that these methods treat channel-wise features equally, which results in degraded representation ability of the neural network. To solve this problem, we propose a new model called MRI Cascaded Channel-wise Attention Network (MICCAN), highlighted by three components: (i) a variant of U-net with Channel-wise Attention (UCA) module, (ii) a long skip connection and (iii) a combined loss. Our model is able to attend to salient information by filtering irrelevant features and also concentrate on high-frequency information by enforcing low-frequency information bypassed to the final output. We conduct both quantitative evaluation and qualitative analysis of our method on a cardiac dataset. The experiment shows that our method achieves very promising results in terms of three common metrics on the MRI reconstruction with low undersampled k-space data.