Callen MacPhee

Yiming Zhou, Callen MacPhee, Madhuri Suthar et al.

PhyCV is the first computer vision library which utilizes algorithms directly derived from the equations of physics governing physical phenomena. The algorithms appearing in the current release emulate, in a metaphoric sense, the propagation of light through a physical medium with natural and engineered diffractive properties followed by coherent detection. Unlike traditional algorithms that are a sequence of hand-crafted empirical rules or deep learning algorithms that are usually data-driven and computationally heavy, physics-inspired algorithms leverage physical laws of nature as blueprints for inventing algorithms. PhyCV features low-dimensionality and high- efficiency, making it ideal for edge computing applications. We demonstrate real-time video processing on NVIDIA Jetson Nano using PhyCV. In addition, these algorithms have the potential to be implemented in real physical devices for fast and efficient computation in the form of analog computing. The open-sourced code is available at https://github.com/JalaliLabUCLA/phycv

Callen MacPhee, Yiming Zhou, Koichiro Kishima et al.

Deep learning has achieved remarkable success in medical image analysis, yet its performance remains highly sensitive to the heterogeneity of clinical data. Differences in imaging hardware, staining protocols, and acquisition conditions produce substantial domain shifts that degrade model generalization across institutions. Here we present a physics-based data preprocessing framework based on the PhyCV (Physics-Inspired Computer Vision) family of algorithms, which standardizes medical images through deterministic transformations derived from optical physics. The framework models images as spatially varying optical fields that undergo a virtual diffractive propagation followed by coherent phase detection. This process suppresses non-semantic variability such as color and illumination differences while preserving diagnostically relevant texture and structural features. When applied to histopathological images from the Camelyon17-WILDS benchmark, PhyCV preprocessing improves out-of-distribution breast-cancer classification accuracy from 70.8% (Empirical Risk Minimization baseline) to 90.9%, matching or exceeding data-augmentation and domain-generalization approaches at negligible computational cost. Because the transform is physically interpretable, parameterizable, and differentiable, it can be deployed as a fixed preprocessing stage or integrated into end-to-end learning. These results establish PhyCV as a generalizable data refinery for medical imaging-one that harmonizes heterogeneous datasets through first-principles physics, improving robustness, interpretability, and reproducibility in clinical AI systems.

Callen MacPhee, Yiming Zhou, Bahram Jalali

Deep neural networks (DNNs) have achieved exceptional performance across various fields by learning complex, nonlinear mappings from large-scale datasets. However, they face challenges such as high memory requirements and computational costs with limited interpretability. This paper introduces an approach where master equations of physics are converted into multilayered networks that are trained via backpropagation. The resulting general-purpose model effectively encodes data in the properties of the underlying physical system. In contrast to existing methods wherein a trained neural network is used as a computationally efficient alternative for solving physical equations, our approach directly treats physics equations as trainable models. We demonstrate this physical embedding concept with the Nonlinear Schrödinger Equation (NLSE), which acts as trainable architecture for learning complex patterns including nonlinear mappings and memory effects from data. The network embeds data representation in orders of magnitude fewer parameters than conventional neural networks when tested on time series data. Notably, the trained "Nonlinear Schrödinger Network" is interpretable, with all parameters having physical meanings. This interpretability offers insight into the underlying dynamics of the system that produced the data. The proposed method of replacing traditional DNN feature learning architectures with physical equations is also extended to the Gross-Pitaevskii Equation, demonstrating the broad applicability of the framework to other master equations of physics. Among our results, an ablation study quantifies the relative importance of physical terms such as dispersion, nonlinearity, and potential energy for classification accuracy. We also outline the limitations of this approach as it relates to generalizability.

Callen MacPhee, Madhuri Suthar, Bahram Jalali

Phase-Stretch Adaptive Gradient-Field Extractor (PAGE) is an edge detection algorithm that is inspired by physics of electromagnetic diffraction and dispersion. A computational imaging algorithm, it identifies edges, their orientations and sharpness in a digital image where the image brightness changes abruptly. Edge detection is a basic operation performed by the eye and is crucial to visual perception. PAGE embeds an original image into a set of feature maps that can be used for object representation and classification. The algorithm performs exceptionally well as an edge and texture extractor in low light level and low contrast images. This manuscript is prepared to support the open-source code which is being simultaneously made available within the GitHub repository https://github.com/JalaliLabUCLA/Phase-Stretch-Adaptive-Gradient-field-Extractor/.

Jonathan Gallagher, Yasaman Esfandiari, Callen MacPhee et al.

This paper establishes a mathematically precise definition of dataset poisoning attack and proves that the very act of effectively poisoning a dataset ensures that the attack can be effectively detected. On top of a mathematical guarantee that dataset poisoning is identifiable by a new statistical test that we call the Conformal Separability Test, we provide experimental evidence that we can adequately detect poisoning attempts in the real world.