Chen Zu

Yang Yuxiang, Zeng Xinyi, Zeng Pinxian et al.

Multi-source Domain Adaptation (MDA) aims to transfer knowledge from multiple labeled source domains to an unlabeled target domain. Nevertheless, traditional methods primarily focus on achieving inter-domain alignment through sample-level constraints, such as Maximum Mean Discrepancy (MMD), neglecting three pivotal aspects: 1) the potential of data augmentation, 2) the significance of intra-domain alignment, and 3) the design of cluster-level constraints. In this paper, we introduce a novel hardness-driven strategy for MDA tasks, named "A3MDA" , which collectively considers these three aspects through Adaptive hardness quantification and utilization in both data Augmentation and domain Alignment.To achieve this, "A3MDA" progressively proposes three Adaptive Hardness Measurements (AHM), i.e., Basic, Smooth, and Comparative AHMs, each incorporating distinct mechanisms for diverse scenarios. Specifically, Basic AHM aims to gauge the instantaneous hardness for each source/target sample. Then, hardness values measured by Smooth AHM will adaptively adjust the intensity level of strong data augmentation to maintain compatibility with the model's generalization capacity.In contrast, Comparative AHM is designed to facilitate cluster-level constraints. By leveraging hardness values as sample-specific weights, the traditional MMD is enhanced into a weighted-clustered variant, strengthening the robustness and precision of inter-domain alignment. As for the often-neglected intra-domain alignment, we adaptively construct a pseudo-contrastive matrix by selecting harder samples based on the hardness rankings, enhancing the quality of pseudo-labels, and shaping a well-clustered target feature space. Experiments on multiple MDA benchmarks show that " A3MDA " outperforms other methods.

Song Tang, Chunxiao Zu, Wenxin Su et al.

Few-shot Semantic Segmentation(FSS)aim to adapt a pre-trained model to new classes with as few as a single labeled training sample per class. The existing prototypical work used in natural image scenarios biasedly focus on capturing foreground's discrimination while employing a simplistic representation for background, grounded on the inherent observation separation between foreground and background. However, this paradigm is not applicable to medical images where the foreground and background share numerous visual features, necessitating a more detailed description for background. In this paper, we present a new pluggable Background-fused prototype(Bro)approach for FSS in medical images. Instead of finding a commonality of background subjects in support image, Bro incorporates this background with two pivot designs. Specifically, Feature Similarity Calibration(FeaC)initially reduces noise in the support image by employing feature cross-attention with the query image. Subsequently, Hierarchical Channel Adversarial Attention(HiCA)merges the background into comprehensive prototypes. We achieve this by a channel groups-based attention mechanism, where an adversarial Mean-Offset structure encourages a coarse-to-fine fusion. Extensive experiments show that previous state-of-the-art methods, when paired with Bro, experience significant performance improvements. This demonstrates a more integrated way to represent backgrounds specifically for medical image.

Wenxin Su, Song Tang, Xiaofeng Liu et al.

Domain shift (the difference between source and target domains) poses a significant challenge in clinical applications, e.g., Diabetic Retinopathy (DR) grading. Despite considering certain clinical requirements, like source data privacy, conventional transfer methods are predominantly model-centered and often struggle to prevent model-targeted attacks. In this paper, we address a challenging Online Model-aGnostic Domain Adaptation (OMG-DA) setting, driven by the demands of clinical environments. This setting is characterized by the absence of the model and the flow of target data. To tackle the new challenge, we propose a novel approach, Generative Unadversarial ExampleS (GUES), which enables adaptation from a data-centric perspective. Specifically, we first theoretically reformulate conventional perturbation optimization in a generative way--learning a perturbation generation function with a latent input variable. During model instantiation, we leverage a Variational AutoEncoder to express this function. The encoder with the reparameterization trick predicts the latent input, whilst the decoder is responsible for the generation. Furthermore, the saliency map is selected as pseudo-perturbation labels. Because it not only captures potential lesions but also theoretically provides an upper bound on the function input, enabling the identification of the latent variable. Extensive comparative experiments on DR benchmarks with both frozen pre-trained models and trainable models demonstrate the superiority of GUES, showing robustness even with small batch size.

Zhang Qixiang, Yang Yuxiang, Zu Chen et al.

Semi-supervised learning (SSL) is a popular solution to alleviate the high annotation cost in medical image classification. As a main branch of SSL, consistency regularization engages in imposing consensus between the predictions of a single sample from different views, termed as Absolute Location consistency (AL-c). However, only AL-c may be insufficient. Just like when diagnosing a case in practice, besides the case itself, the doctor usually refers to certain related trustworthy cases to make more reliable decisions.Therefore, we argue that solely relying on AL-c may ignore the relative differences across samples, which we interpret as relative locations, and only exploit limited information from one perspective. To address this issue, we propose a Sample Consistency Mean Teacher (SCMT) which not only incorporates AL c but also additionally enforces consistency between the samples' relative similarities to its related samples, called Relative Location consistency (RL c). AL c and RL c conduct consistency regularization from two different perspectives, jointly extracting more diverse semantic information for classification. On the other hand, due to the highly similar structures in medical images, the sample distribution could be overly dense in feature space, making their relative locations susceptible to noise. To tackle this problem, we further develop a Sample Scatter Mean Teacher (SSMT) by utilizing contrastive learning to sparsify the sample distribution and obtain robust and effective relative locations. Extensive experiments on different datasets demonstrate the superiority of our method.

Yuang Shi, Chen Zu, Mei Hong et al.

With the increasing amounts of high-dimensional heterogeneous data to be processed, multi-modality feature selection has become an important research direction in medical image analysis. Traditional methods usually depict the data structure using fixed and predefined similarity matrix for each modality separately, without considering the potential relationship structure across different modalities. In this paper, we propose a novel multi-modality feature selection method, which performs feature selection and local similarity learning simultaniously. Specially, a similarity matrix is learned by jointly considering different imaging modalities. And at the same time, feature selection is conducted by imposing sparse l_{2, 1} norm constraint. The effectiveness of our proposed joint learning method can be well demonstrated by the experimental results on Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, which outperforms existing the state-of-the-art multi-modality approaches.

Pin Tang, Chen Zu, Mei Hong et al.

Precise and accurate segmentation of the most common head-and-neck tumor, nasopharyngeal carcinoma (NPC), in MRI sheds light on treatment and regulatory decisions making. However, the large variations in the lesion size and shape of NPC, boundary ambiguity, as well as the limited available annotated samples conspire NPC segmentation in MRI towards a challenging task. In this paper, we propose a Dense SegU-net (DSU-net) framework for automatic NPC segmentation in MRI. Our contribution is threefold. First, different from the traditional decoder in U-net using upconvolution for upsamling, we argue that the restoration from low resolution features to high resolution output should be capable of preserving information significant for precise boundary localization. Hence, we use unpooling to unsample and propose SegU-net. Second, to combat the potential vanishing-gradient problem, we introduce dense blocks which can facilitate feature propagation and reuse. Third, using only cross entropy (CE) as loss function may bring about troubles such as miss-prediction, therefore we propose to use a loss function comprised of both CE loss and Dice loss to train the network. Quantitative and qualitative comparisons are carried out extensively on in-house datasets, the experimental results show that our proposed architecture outperforms the existing state-of-the-art segmentation networks.