Michael Keller

Nishad Kulkarni, Alexandra K. Martinson, Nicholas L. Rider et al.

Rare diseases such as inborn errors of immunity (IEI) require early diagnosis to prevent end organ damage and improve quality of life. Hurdles in accessing and curating large scale electronic health record (EHR) data limit routine data driven analyses to remain on the forefront of IEI and other rare disease trends. Development of machine learning (ML) algorithms in IEI for pattern recognition as well as published methodology examining how to systematically process and integrate complex medical data is limited. Our proposed pipeline, including data curation and ML clustering algorithms, is designed to recognize novel rare disease patterns and extract IEI- associated features from a national data registry. Our methodology for EHR data formatting and processing presents the pipeline that transforms raw immunologic lab data into vectors. This is further combined with hyperparameter tuning for diseases pattern recognition via clustering. This study refines IEI feature awareness, develops data tool kits for rare disease populations analysis, and expands on transforming complex medical records in data structures interpretable by unsupervised ML.

Fabien H Wagner, Ricardo Dalagnol, Griffin Carter et al.

Tree canopy height is one of the most important indicators of forest biomass, productivity, and ecosystem structure, but it is challenging to measure accurately from the ground and from space. Here, we used a U-Net model adapted for regression to map the mean tree canopy height in the Amazon forest from Planet NICFI images at ~4.78 m spatial resolution for the period 2020-2024. The U-Net model was trained using canopy height models computed from aerial LiDAR data as a reference, along with their corresponding Planet NICFI images. Predictions of tree heights on the validation sample exhibited a mean error of 3.68 m and showed relatively low systematic bias across the entire range of tree heights present in the Amazon forest. Our model successfully estimated canopy heights up to 40-50 m without much saturation, outperforming existing canopy height products from global models in this region. We determined that the Amazon forest has an average canopy height of ~22 m. Events such as logging or deforestation could be detected from changes in tree height, and encouraging results were obtained to monitor the height of regenerating forests. These findings demonstrate the potential for large-scale mapping and monitoring of tree height for old and regenerating Amazon forests using Planet NICFI imagery.