Megha Thukral

Hao Zhou, Simon A. Lee, Cyrus Tanade et al.

Biosignals acquired from different locations on the body often provide temporally ordered views of the same underlying physiological process. However, most existing self supervised learning methods treat these signals as interchangeable views, overlooking the directional temporal dynamics that link them. A canonical example is the relationship between electrocardiography (ECG), which captures the electrical activation initiating each heartbeat, and photoplethysmography (PPG), which records the resulting peripheral pulse delayed by vascular dynamics. To capture this structured relationship, we introduce xMAE, a biosignal pretraining framework that leverages masked cross modal reconstruction across temporally ordered biosignals as a training time constraint to encourage physiologically meaningful timing structure in the learned representations. We show that pretraining with xMAE yields representations that outperform both unimodal and multimodal baselines on 15 of 19 downstream tasks, including cardiovascular outcome prediction, abnormal laboratory test detection, sleep staging, and demographic inference, while generalizing across devices, body locations, and acquisition settings. Further analysis suggests that the ECG PPG timing structure is reflected in the learned PPG representations. More broadly, xMAE demonstrates the effectiveness of incorporating temporal structure into multimodal pretraining when signals observe different stages of a shared underlying process. Code is available at https://github.com/hzhou3/xMAE.

Megha Thukral, Harish Haresamudram, Thomas Ploetz

The ubiquitous availability of smartphones and smartwatches with integrated inertial measurement units (IMUs) enables straightforward capturing of human activities. For specific applications of sensor based human activity recognition (HAR), however, logistical challenges and burgeoning costs render especially the ground truth annotation of such data a difficult endeavor, resulting in limited scale and diversity of datasets. Transfer learning, i.e., leveraging publicly available labeled datasets to first learn useful representations that can then be fine-tuned using limited amounts of labeled data from a target domain, can alleviate some of the performance issues of contemporary HAR systems. Yet they can fail when the differences between source and target conditions are too large and/ or only few samples from a target application domain are available, each of which are typical challenges in real-world human activity recognition scenarios. In this paper, we present an approach for economic use of publicly available labeled HAR datasets for effective transfer learning. We introduce a novel transfer learning framework, Cross-Domain HAR, which follows the teacher-student self-training paradigm to more effectively recognize activities with very limited label information. It bridges conceptual gaps between source and target domains, including sensor locations and type of activities. Through our extensive experimental evaluation on a range of benchmark datasets, we demonstrate the effectiveness of our approach for practically relevant few shot activity recognition scenarios. We also present a detailed analysis into how the individual components of our framework affect downstream performance.

Zikang Leng, Megha Thukral, Yaqi Liu et al.

A major challenge in developing robust and generalizable Human Activity Recognition (HAR) systems for smart homes is the lack of large and diverse labeled datasets. Variations in home layouts, sensor configurations, and individual behaviors further exacerbate this issue. To address this, we leverage the idea of embodied AI agents -- virtual agents that perceive and act within simulated environments guided by internal world models. We introduce AgentSense, a virtual data generation pipeline in which agents live out daily routines in simulated smart homes, with behavior guided by Large Language Models (LLMs). The LLM generates diverse synthetic personas and realistic routines grounded in the environment, which are then decomposed into fine-grained actions. These actions are executed in an extended version of the VirtualHome simulator, which we augment with virtual ambient sensors that record the agents' activities. Our approach produces rich, privacy-preserving sensor data that reflects real-world diversity. We evaluate AgentSense on five real HAR datasets. Models pretrained on the generated data consistently outperform baselines, especially in low-resource settings. Furthermore, combining the generated virtual sensor data with a small amount of real data achieves performance comparable to training on full real-world datasets. These results highlight the potential of using LLM-guided embodied agents for scalable and cost-effective sensor data generation in HAR. Our code is publicly available at https://github.com/ZikangLeng/AgentSense.

Megha Thukral, Sourish Gunesh Dhekane, Shruthi K. Hiremath et al.

Human activity recognition (HAR) using ambient sensors in smart homes has numerous applications for human healthcare and wellness. However, building general-purpose HAR models that can be deployed to new smart home environments requires a significant amount of annotated sensor data and training overhead. Most smart homes vary significantly in their layouts, i.e., floor plans and the specifics of sensors embedded, resulting in low generalizability of HAR models trained for specific homes. We address this limitation by introducing a novel, layout-agnostic modeling approach for HAR systems in smart homes that utilizes the transferrable representational capacity of natural language descriptions of raw sensor data. To this end, we generate Textual Descriptions Of Sensor Triggers (TDOST) that encapsulate the surrounding trigger conditions and provide cues for underlying activities to the activity recognition models. Leveraging textual embeddings, rather than raw sensor data, we create activity recognition systems that predict standard activities across homes without either (re-)training or adaptation on target homes. Through an extensive evaluation, we demonstrate the effectiveness of TDOST-based models in unseen smart homes through experiments on benchmarked CASAS datasets. Furthermore, we conduct a detailed analysis of how the individual components of our approach affect downstream activity recognition performance.

Megha Thukral, Dong Gyun Kang, Rudra Pratap Singh et al.

Electronic health record foundation models typically treat ICD diagnosis codes as flat tokens, overlooking the clinically meaningful hierarchical structure that captures disease families, subcategories, and fine-grained diagnostic detail. As a result, existing EHR representation learning methods do not explicitly exploit the hierarchical structure already present in the coding system. In this work, we study ICD-10-CM hierarchy as a general inductive bias for clinical representation learning. We investigate two complementary mechanisms for incorporating hierarchy: first, by augmenting diagnosis sequences in a BERT-style transformer with tokens corresponding to different levels of the ICD hierarchy, and second, by injecting hierarchy into graph-based code representations through hierarchy-aware edges combined with diagnosis co-occurrence structure. Across these settings, we evaluate whether explicit hierarchy improves downstream prediction, which levels of the hierarchy are most useful, whether hierarchy encoding improves transfer across datasets, and how hierarchy reshapes embedding similarity structure. We conduct experiments on two large-scale real-world clinical datasets: MIMIC-IV, used for pretraining and in-domain evaluation, and eICU, used to assess cross-dataset transfer via frozen encoder probing. Our findings show that explicitly encoding ICD hierarchy improves over flat code representations in both in-domain and cross-dataset settings, while revealing that the most useful level of hierarchy depends on both the task and the modeling approach. More broadly, we focus on hierarchy-aware EHR representation learning and show that the benefits of encoding hierarchy are generalizable across modeling settings and hierarchy levels.