Yiping Li

Tim J. M. Jaspers, Ronald L. P. D. de Jong, Yasmina Al Khalil et al.

Over the past decade, computer vision applications in minimally invasive surgery have rapidly increased. Despite this growth, the impact of surgical computer vision remains limited compared to other medical fields like pathology and radiology, primarily due to the scarcity of representative annotated data. Whereas transfer learning from large annotated datasets such as ImageNet has been conventionally the norm to achieve high-performing models, recent advancements in self-supervised learning (SSL) have demonstrated superior performance. In medical image analysis, in-domain SSL pretraining has already been shown to outperform ImageNet-based initialization. Although unlabeled data in the field of surgical computer vision is abundant, the diversity within this data is limited. This study investigates the role of dataset diversity in SSL for surgical computer vision, comparing procedure-specific datasets against a more heterogeneous general surgical dataset across three different downstream surgical applications. The obtained results show that using solely procedure-specific data can lead to substantial improvements of 13.8%, 9.5%, and 36.8% compared to ImageNet pretraining. However, extending this data with more heterogeneous surgical data further increases performance by an additional 5.0%, 5.2%, and 2.5%, suggesting that increasing diversity within SSL data is beneficial for model performance. The code and pretrained model weights are made publicly available at https://github.com/TimJaspers0801/SurgeNet.

Yiping Li, Zhiyu An, Wan Du

Communication in Large Language Model (LLM)-based multi-agent systems is moving beyond discrete tokens to preserve richer context. Recent work such as LatentMAS enables agents to exchange latent messages through full key-value (KV) caches. However, full KV relay incurs high memory and communication cost. We adapt eviction-style KV compression to this setting and introduce Orthogonal Backfill (OBF) to mitigate information loss from hard eviction. OBF injects a low-rank orthogonal residual from discarded KV states into the retained KV states. We evaluate proposed method against full KV relay on nine standard benchmarks spanning mathematical reasoning, coding, and knowledge-intensive QA. It achieves performance comparable to full KV relay while reducing communication cost by 79.8%--89.4%. OBF further improves the performance and achieves the best results on 7 of the 9 benchmarks. This suggests that more information does not necessarily lead to better communication; preserving the most useful information matters more. Our codebase is publicly available on https://github.com/markli404/When-Less-Latent-Leads-to-Better-Relay.

Tim J. M. Jaspers, Ronald L. P. D. de Jong, Yiping Li et al.

Foundation models have revolutionized computer vision by achieving vastly superior performance across diverse tasks through large-scale pretraining on extensive datasets. However, their application in surgical computer vision has been limited. This study addresses this gap by introducing SurgeNetXL, a novel surgical foundation model that sets a new benchmark in surgical computer vision. Trained on the largest reported surgical dataset to date, comprising over 4.7 million video frames, SurgeNetXL achieves consistent top-tier performance across six datasets spanning four surgical procedures and three tasks, including semantic segmentation, phase recognition, and critical view of safety (CVS) classification. Compared with the best-performing surgical foundation models, SurgeNetXL shows mean improvements of 2.4, 9.0, and 12.6 percent for semantic segmentation, phase recognition, and CVS classification, respectively. Additionally, SurgeNetXL outperforms the best-performing ImageNet-based variants by 14.4, 4.0, and 1.6 percent in the respective tasks. In addition to advancing model performance, this study provides key insights into scaling pretraining datasets, extending training durations, and optimizing model architectures specifically for surgical computer vision. These findings pave the way for improved generalizability and robustness in data-scarce scenarios, offering a comprehensive framework for future research in this domain. All models and a subset of the SurgeNetXL dataset, including over 2 million video frames, are publicly available at: https://github.com/TimJaspers0801/SurgeNet.

Zhangjun Zhou, Yiping Li, Chunlin Zhong et al.

While the human visual system employs distinct mechanisms to perceive salient and camouflaged objects, existing models struggle to disentangle these tasks. Specifically, salient object detection (SOD) models frequently misclassify camouflaged objects as salient, while camouflaged object detection (COD) models conversely misinterpret salient objects as camouflaged. We hypothesize that this can be attributed to two factors: (i) the specific annotation paradigm of current SOD and COD datasets, and (ii) the lack of explicit attribute relationship modeling in current models. Prevalent SOD/COD datasets enforce a mutual exclusivity constraint, assuming scenes contain either salient or camouflaged objects, which poorly aligns with the real world. Furthermore, current SOD/COD methods are primarily designed for these highly constrained datasets and lack explicit modeling of the relationship between salient and camouflaged objects. In this paper, to promote the development of unconstrained salient and camouflaged object detection, we construct a large-scale dataset, USC12K, which features comprehensive labels and four different scenes that cover all possible logical existence scenarios of both salient and camouflaged objects. To explicitly model the relationship between salient and camouflaged objects, we propose a model called USCNet, which introduces two distinct prompt query mechanisms for modeling inter-sample and intra-sample attribute relationships. Additionally, to assess the model's ability to distinguish between salient and camouflaged objects, we design an evaluation metric called CSCS. The proposed method achieves state-of-the-art performance across all scenes in various metrics. The code and dataset will be available at https://github.com/ssecv/USCNet.

Shuang Hao, Wenfeng Han, Tao Jiang et al.

In the rapidly evolving field of artificial intelligence, the creation and utilization of synthetic datasets have become increasingly significant. This report delves into the multifaceted aspects of synthetic data, particularly emphasizing the challenges and potential biases these datasets may harbor. It explores the methodologies behind synthetic data generation, spanning traditional statistical models to advanced deep learning techniques, and examines their applications across diverse domains. The report also critically addresses the ethical considerations and legal implications associated with synthetic datasets, highlighting the urgent need for mechanisms to ensure fairness, mitigate biases, and uphold ethical standards in AI development.

Yiping Li, Ronald de Jong, Sahar Nasirihaghighi et al.

Accurate surgical phase recognition is crucial for computer-assisted interventions and surgical video analysis. Annotating long surgical videos is labor-intensive, driving research toward leveraging unlabeled data for strong performance with minimal annotations. Although self-supervised learning has gained popularity by enabling large-scale pretraining followed by fine-tuning on small labeled subsets, semi-supervised approaches remain largely underexplored in the surgical domain. In this work, we propose a video transformer-based model with a robust pseudo-labeling framework. Our method incorporates temporal consistency regularization for unlabeled data and contrastive learning with class prototypes, which leverages both labeled data and pseudo-labels to refine the feature space. Through extensive experiments on the private RAMIE (Robot-Assisted Minimally Invasive Esophagectomy) dataset and the public Cholec80 dataset, we demonstrate the effectiveness of our approach. By incorporating unlabeled data, we achieve state-of-the-art performance on RAMIE with a 4.9% accuracy increase and obtain comparable results to full supervision while using only 1/4 of the labeled data on Cholec80. Our findings establish a strong benchmark for semi-supervised surgical phase recognition, paving the way for future research in this domain.

Yiping Li, Romy van Jaarsveld, Ronald de Jong et al.

Robotic-assisted minimally invasive esophagectomy (RAMIE) is a recognized treatment for esophageal cancer, offering better patient outcomes compared to open surgery and traditional minimally invasive surgery. RAMIE is highly complex, spanning multiple anatomical areas and involving repetitive phases and non-sequential phase transitions. Our goal is to leverage deep learning for surgical phase recognition in RAMIE to provide intraoperative support to surgeons. To achieve this, we have developed a new surgical phase recognition dataset comprising 27 videos. Using this dataset, we conducted a comparative analysis of state-of-the-art surgical phase recognition models. To more effectively capture the temporal dynamics of this complex procedure, we developed a novel deep learning model featuring an encoder-decoder structure with causal hierarchical attention, which demonstrates superior performance compared to existing models.

Ronald L. P. D. de Jong, Yasmina al Khalil, Tim J. M. Jaspers et al.

Esophageal cancer is among the most common types of cancer worldwide. It is traditionally treated using open esophagectomy, but in recent years, robot-assisted minimally invasive esophagectomy (RAMIE) has emerged as a promising alternative. However, robot-assisted surgery can be challenging for novice surgeons, as they often suffer from a loss of spatial orientation. Computer-aided anatomy recognition holds promise for improving surgical navigation, but research in this area remains limited. In this study, we developed a comprehensive dataset for semantic segmentation in RAMIE, featuring the largest collection of vital anatomical structures and surgical instruments to date. Handling this diverse set of classes presents challenges, including class imbalance and the recognition of complex structures such as nerves. This study aims to understand the challenges and limitations of current state-of-the-art algorithms on this novel dataset and problem. Therefore, we benchmarked eight real-time deep learning models using two pretraining datasets. We assessed both traditional and attention-based networks, hypothesizing that attention-based networks better capture global patterns and address challenges such as occlusion caused by blood or other tissues. The benchmark includes our RAMIE dataset and the publicly available CholecSeg8k dataset, enabling a thorough assessment of surgical segmentation tasks. Our findings indicate that pretraining on ADE20k, a dataset for semantic segmentation, is more effective than pretraining on ImageNet. Furthermore, attention-based models outperform traditional convolutional neural networks, with SegNeXt and Mask2Former achieving higher Dice scores, and Mask2Former additionally excelling in average symmetric surface distance.

Prabhant Singh, Yiping Li, Yasmina Al Khalil

Fine-tuning pre-trained models has become a cornerstone of modern machine learning, allowing practitioners to achieve high performance with limited labeled data. In surgical video analysis, where expert annotations are especially time-consuming and costly, identifying the most suitable pre-trained model for a downstream task is both critical and challenging. Source-independent transferability estimation (SITE) offers a solution by predicting how well a model will fine-tune on target data using only its embeddings or outputs, without requiring full retraining. In this work, we formalize SITE for surgical phase recognition and provide the first comprehensive benchmark of three representative metrics, LogME, H-Score, and TransRate, on two diverse datasets (RAMIE and AutoLaparo). Our results show that LogME, particularly when aggregated by the minimum per-subset score, aligns most closely with fine-tuning accuracy; H-Score yields only weak predictive power; and TransRate often inverses true model rankings. Ablation studies show that when candidate models have similar performances, transferability estimates lose discriminative power, emphasizing the importance of maintaining model diversity or using additional validation. We conclude with practical guidelines for model selection and outline future directions toward domain-specific metrics, theoretical foundations, and interactive benchmarking tools.

Haozheng Xu, Alistair Weld, Chi Xu et al.

Accurate instrument pose estimation is a crucial step towards the future of robotic surgery, enabling applications such as autonomous surgical task execution. Vision-based methods for surgical instrument pose estimation provide a practical approach to tool tracking, but they often require markers to be attached to the instruments. Recently, more research has focused on the development of marker-less methods based on deep learning. However, acquiring realistic surgical data, with ground truth instrument poses, required for deep learning training, is challenging. To address the issues in surgical instrument pose estimation, we introduce the Surgical Robot Instrument Pose Estimation (SurgRIPE) challenge, hosted at the 26th International Conference on Medical Image Computing and Computer-Assisted Intervention (MICCAI) in 2023. The objectives of this challenge are: (1) to provide the surgical vision community with realistic surgical video data paired with ground truth instrument poses, and (2) to establish a benchmark for evaluating markerless pose estimation methods. The challenge led to the development of several novel algorithms that showcased improved accuracy and robustness over existing methods. The performance evaluation study on the SurgRIPE dataset highlights the potential of these advanced algorithms to be integrated into robotic surgery systems, paving the way for more precise and autonomous surgical procedures. The SurgRIPE challenge has successfully established a new benchmark for the field, encouraging further research and development in surgical robot instrument pose estimation.

Sahar Nasirihaghighi, Negin Ghamsarian, Yiping Li et al.

Medical image segmentation is clinically important, yet data privacy and the cost of expert annotation limit the availability of labeled data. Federated semi-supervised learning (FSSL) offers a solution but faces two challenges: pseudo-label reliability depends on the strength of local models, and client devices often require compact or heterogeneous architectures due to limited computational resources. These constraints reduce the quality and stability of pseudo-labels, while large models, though more accurate, cannot be trained or used for routine inference on client devices. We propose SAM-Fed, a federated semi-supervised framework that leverages a high-capacity segmentation foundation model to guide lightweight clients during training. SAM-Fed combines dual knowledge distillation with an adaptive agreement mechanism to refine pixel-level supervision. Experiments on skin lesion and polyp segmentation across homogeneous and heterogeneous settings show that SAM-Fed consistently outperforms state-of-the-art FSSL methods.

Tobias Rueckert, David Rauber, Raphaela Maerkl et al.

Reliable recognition and localization of surgical instruments in endoscopic video recordings are foundational for a wide range of applications in computer- and robot-assisted minimally invasive surgery (RAMIS), including surgical training, skill assessment, and autonomous assistance. However, robust performance under real-world conditions remains a significant challenge. Incorporating surgical context - such as the current procedural phase - has emerged as a promising strategy to improve robustness and interpretability. To address these challenges, we organized the Surgical Procedure Phase, Keypoint, and Instrument Recognition (PhaKIR) sub-challenge as part of the Endoscopic Vision (EndoVis) challenge at MICCAI 2024. We introduced a novel, multi-center dataset comprising thirteen full-length laparoscopic cholecystectomy videos collected from three distinct medical institutions, with unified annotations for three interrelated tasks: surgical phase recognition, instrument keypoint estimation, and instrument instance segmentation. Unlike existing datasets, ours enables joint investigation of instrument localization and procedural context within the same data while supporting the integration of temporal information across entire procedures. We report results and findings in accordance with the BIAS guidelines for biomedical image analysis challenges. The PhaKIR sub-challenge advances the field by providing a unique benchmark for developing temporally aware, context-driven methods in RAMIS and offers a high-quality resource to support future research in surgical scene understanding.

Li Wang, Yiping Li, Xiangzheng Fu et al.

Antimicrobial peptides (AMPs) have exhibited unprecedented potential as biomaterials in combating multidrug-resistant bacteria. Despite the increasing adoption of artificial intelligence for novel AMP design, challenges pertaining to conflicting attributes such as activity, hemolysis, and toxicity have significantly impeded the progress of researchers. This paper introduces a paradigm shift by considering multiple attributes in AMP design. Presented herein is a novel approach termed Hypervolume-driven Multi-objective Antimicrobial Peptide Design (HMAMP), which prioritizes the simultaneous optimization of multiple attributes of AMPs. By synergizing reinforcement learning and a gradient descent algorithm rooted in the hypervolume maximization concept, HMAMP effectively expands exploration space and mitigates the issue of pattern collapse. This method generates a wide array of prospective AMP candidates that strike a balance among diverse attributes. Furthermore, we pinpoint knee points along the Pareto front of these candidate AMPs. Empirical results across five benchmark models substantiate that HMAMP-designed AMPs exhibit competitive performance and heightened diversity. A detailed analysis of the helical structures and molecular dynamics simulations for ten potential candidate AMPs validates the superiority of HMAMP in the realm of multi-objective AMP design. The ability of HMAMP to systematically craft AMPs considering multiple attributes marks a pioneering milestone, establishing a universal computational framework for the multi-objective design of AMPs.