Dong Yuan

Kacy Zhou, Jiawen Wen, Nan Yang et al.

While deep learning has become a core functional module of most software systems, concerns regarding the fairness of ML predictions have emerged as a significant issue that affects prediction results due to discrimination. Intersectional bias, which disproportionately affects members of subgroups, is a prime example of this. For instance, a machine learning model might exhibit bias against darker-skinned women, while not showing bias against individuals with darker skin or women. This problem calls for effective fairness testing before the deployment of such deep learning models in real-world scenarios. However, research into detecting such bias is currently limited compared to research on individual and group fairness. Existing tools to investigate intersectional bias lack important features such as support for multiple fairness metrics, fast and efficient computation, and user-friendly interpretation. This paper introduces Fairpriori, a novel biased subgroup discovery method, which aims to address these limitations. Fairpriori incorporates the frequent itemset generation algorithm to facilitate effective and efficient investigation of intersectional bias by producing fast fairness metric calculations on subgroups of a dataset. Through comparison with the state-of-the-art methods (e.g., Themis, FairFictPlay, and TestSGD) under similar conditions, Fairpriori demonstrates superior effectiveness and efficiency when identifying intersectional bias. Specifically, Fairpriori is easier to use and interpret, supports a wider range of use cases by accommodating multiple fairness metrics, and exhibits higher efficiency in computing fairness metrics. These findings showcase Fairpriori's potential for effectively uncovering subgroups affected by intersectional bias, supported by its open-source tooling at https://anonymous.4open.science/r/Fairpriori-0320.

Yuchen Ren, Zhiyuan Chen, Lifeng Qiao et al.

RNA plays a pivotal role in translating genetic instructions into functional outcomes, underscoring its importance in biological processes and disease mechanisms. Despite the emergence of numerous deep learning approaches for RNA, particularly universal RNA language models, there remains a significant lack of standardized benchmarks to assess the effectiveness of these methods. In this study, we introduce the first comprehensive RNA benchmark BEACON (\textbf{BE}nchm\textbf{A}rk for \textbf{CO}mprehensive R\textbf{N}A Task and Language Models). First, BEACON comprises 13 distinct tasks derived from extensive previous work covering structural analysis, functional studies, and engineering applications, enabling a comprehensive assessment of the performance of methods on various RNA understanding tasks. Second, we examine a range of models, including traditional approaches like CNNs, as well as advanced RNA foundation models based on language models, offering valuable insights into the task-specific performances of these models. Third, we investigate the vital RNA language model components from the tokenizer and positional encoding aspects. Notably, our findings emphasize the superiority of single nucleotide tokenization and the effectiveness of Attention with Linear Biases (ALiBi) over traditional positional encoding methods. Based on these insights, a simple yet strong baseline called BEACON-B is proposed, which can achieve outstanding performance with limited data and computational resources. The datasets and source code of our benchmark are available at https://github.com/terry-r123/RNABenchmark.

Haonan He, Yuchen Ren, Yining Tang et al.

Large language models (LLMs) have shown remarkable capabilities in general domains, but their application to multi-omics biology remains underexplored. To address this gap, we introduce Biology-Instructions, the first large-scale instruction-tuning dataset for multi-omics biological sequences, including DNA, RNA, proteins, and multi-molecules. This dataset bridges LLMs and complex biological sequence-related tasks, enhancing their versatility and reasoning while maintaining conversational fluency. We also highlight significant limitations of current state-of-the-art LLMs on multi-omics tasks without specialized training. To overcome this, we propose ChatMultiOmics, a strong baseline with a novel three-stage training pipeline, demonstrating superior biological understanding through Biology-Instructions. Both resources are publicly available, paving the way for better integration of LLMs in multi-omics analysis. The Biology-Instructions is publicly available at: https://github.com/hhnqqq/Biology-Instructions.

Dong Yuan, Eti Rastogi, Fen Zhao et al.

Due to the exponential growth of information and the need for efficient information consumption the task of summarization has gained paramount importance. Evaluating summarization accurately and objectively presents significant challenges, particularly when dealing with long and unstructured texts rich in content. Existing methods, such as ROUGE (Lin, 2004) and embedding similarities, often yield scores that have low correlation with human judgements and are also not intuitively understandable, making it difficult to gauge the true quality of the summaries. LLMs can mimic human in giving subjective reviews but subjective scores are hard to interpret and justify. They can be easily manipulated by altering the models and the tones of the prompts. In this paper, we introduce a novel evaluation methodology and tooling designed to address these challenges, providing a more comprehensive, accurate and interpretable assessment of summarization outputs. Our method (SumAutoEval) proposes and evaluates metrics at varying granularity levels, giving objective scores on 4 key dimensions such as completeness, correctness, Alignment and readability. We empirically demonstrate, that SumAutoEval enhances the understanding of output quality with better human correlation.

Yuchen Ren, Wenwei Han, Qianyuan Zhang et al.

As key elements within the central dogma, DNA, RNA, and proteins play crucial roles in maintaining life by guaranteeing accurate genetic expression and implementation. Although research on these molecules has profoundly impacted fields like medicine, agriculture, and industry, the diversity of machine learning approaches-from traditional statistical methods to deep learning models and large language models-poses challenges for researchers in choosing the most suitable models for specific tasks, especially for cross-omics and multi-omics tasks due to the lack of comprehensive benchmarks. To address this, we introduce the first comprehensive multi-omics benchmark COMET (Benchmark for Biological COmprehensive Multi-omics Evaluation Tasks and Language Models), designed to evaluate models across single-omics, cross-omics, and multi-omics tasks. First, we curate and develop a diverse collection of downstream tasks and datasets covering key structural and functional aspects in DNA, RNA, and proteins, including tasks that span multiple omics levels. Then, we evaluate existing foundational language models for DNA, RNA, and proteins, as well as the newly proposed multi-omics method, offering valuable insights into their performance in integrating and analyzing data from different biological modalities. This benchmark aims to define critical issues in multi-omics research and guide future directions, ultimately promoting advancements in understanding biological processes through integrated and different omics data analysis.

Yanli Li, Jehad Ibrahim, Huaming Chen et al.

A large number of federated learning (FL) algorithms have been proposed for different applications and from varying perspectives. However, the evaluation of such approaches often relies on a single metric (e.g., accuracy). Such a practice fails to account for the unique demands and diverse requirements of different use cases. Thus, how to comprehensively evaluate an FL algorithm and determine the most suitable candidate for a designated use case remains an open question. To mitigate this research gap, we introduce the Holistic Evaluation Metrics (HEM) for FL in this work. Specifically, we collectively focus on three primary use cases, which are Internet of Things (IoT), smart devices, and institutions. The evaluation metric encompasses various aspects including accuracy, convergence, computational efficiency, fairness, and personalization. We then assign a respective importance vector for each use case, reflecting their distinct performance requirements and priorities. The HEM index is finally generated by integrating these metric components with their respective importance vectors. Through evaluating different FL algorithms in these three prevalent use cases, our experimental results demonstrate that HEM can effectively assess and identify the FL algorithms best suited to particular scenarios. We anticipate this work sheds light on the evaluation process for pragmatic FL algorithms in real-world applications.

Dong Yuan, Eti Rastogi, Gautam Naik et al.

LLMs are revolutionizing NLP tasks. However, the use of the most advanced LLMs, such as GPT-4, is often prohibitively expensive for most specialized fields. We introduce HEAL, the first continuously trained 13B LLaMA2-based LLM that is purpose-built for medical conversations and measured on automated scribing. Our results demonstrate that HEAL outperforms GPT-4 and PMC-LLaMA in PubMedQA, with an accuracy of 78.4\%. It also achieves parity with GPT-4 in generating medical notes. Remarkably, HEAL surpasses GPT-4 and Med-PaLM 2 in identifying more correct medical concepts and exceeds the performance of human scribes and other comparable models in correctness and completeness.