Xavier F. Cadet

Xavier F. Cadet, Ranya Aloufi, Sara Ahmadi-Abhari et al.

Automating dysarthria assessments offers the opportunity to develop practical, low-cost tools that address the current limitations of manual and subjective assessments. Nonetheless, the small size of most dysarthria datasets makes it challenging to develop automated assessment. Recent research showed that speech representations from models pre-trained on large unlabelled data can enhance Automatic Speech Recognition (ASR) performance for dysarthric speech. We are the first to evaluate the representations from pre-trained state-of-the-art Self-Supervised models across three downstream tasks on dysarthric speech: disease classification, word recognition and intelligibility classification, and under three noise scenarios on the UA-Speech dataset. We show that HuBERT is the most versatile feature extractor across dysarthria classification, word recognition, and intelligibility classification, achieving respectively $+24.7\%, +61\%, \text{and} +7.2\%$ accuracy compared to classical acoustic features.

Xavier F. Cadet, Ranya Aloufi, Alain Miranville et al.

Despite impressive empirical advances of SSL in solving various tasks, the problem of understanding and characterizing SSL representations learned from input data remains relatively under-explored. We provide a comparative analysis of how the representations produced by SSL models differ when masking parts of the input. Specifically, we considered state-of-the-art SSL pretrained models, such as DINOv2, MAE, and SwaV, and analyzed changes at the representation levels across 4 Image Classification datasets. First, we generate variations of the datasets by applying foreground and background segmentation. Then, we conduct statistical analysis using Canonical Correlation Analysis (CCA) and Centered Kernel Alignment (CKA) to evaluate the robustness of the representations learned in SSL models. Empirically, we show that not all models lead to representations that separate foreground, background, and complete images. Furthermore, we test different masking strategies by occluding the center regions of the images to address cases where foreground and background are difficult. For example, the DTD dataset that focuses on texture rather specific objects.

Xavier F. Cadet, Sara Ahmadi-Abhari, Hamed Haddadi

Errors might not have the same consequences depending on the task at hand. Nevertheless, there is limited research investigating the impact of imbalance in the contribution of different features in an error vector. Therefore, we propose the Feature Impact Balance (FIB) score. It measures whether there is a balanced impact of features in the discrepancies between two vectors. We designed the FIB score to lie in [0, 1]. Scores close to 0 indicate that a small number of features contribute to most of the error, and scores close to 1 indicate that most features contribute to the error equally. We experimentally study the FIB on different datasets, using AutoEncoders and Variational AutoEncoders. We show how the feature impact balance varies during training and showcase its usability to support model selection for single output and multi-output tasks.

Wen-ran Li, Xavier F. Cadet, David Medina-Ortiz et al.

Protein design with desirable properties has been a significant challenge for many decades. Generative artificial intelligence is a promising approach and has achieved great success in various protein generation tasks. Notably, diffusion models stand out for their robust mathematical foundations and impressive generative capabilities, offering unique advantages in certain applications such as protein design. In this review, we first give the definition and characteristics of diffusion models and then focus on two strategies: Denoising Diffusion Probabilistic Models and Score-based Generative Models, where DDPM is the discrete form of SGM. Furthermore, we discuss their applications in protein design, peptide generation, drug discovery, and protein-ligand interaction. Finally, we outline the future perspectives of diffusion models to advance autonomous protein design and engineering. The E(3) group consists of all rotations, reflections, and translations in three-dimensions. The equivariance on the E(3) group can keep the physical stability of the frame of each amino acid as much as possible, and we reflect on how to keep the diffusion model E(3) equivariant for protein generation.