Blake Richards

Anthony Zador, Sean Escola, Blake Richards et al. · stanford

Neuroscience has long been an essential driver of progress in artificial intelligence (AI). We propose that to accelerate progress in AI, we must invest in fundamental research in NeuroAI. A core component of this is the embodied Turing test, which challenges AI animal models to interact with the sensorimotor world at skill levels akin to their living counterparts. The embodied Turing test shifts the focus from those capabilities like game playing and language that are especially well-developed or uniquely human to those capabilities, inherited from over 500 million years of evolution, that are shared with all animals. Building models that can pass the embodied Turing test will provide a roadmap for the next generation of AI.

Chen Sun, Wannan Yang, Thomas Jiralerspong et al.

In real life, success is often contingent upon multiple critical steps that are distant in time from each other and from the final reward. These critical steps are challenging to identify with traditional reinforcement learning (RL) methods that rely on the Bellman equation for credit assignment. Here, we present a new RL algorithm that uses offline contrastive learning to hone in on these critical steps. This algorithm, which we call Contrastive Retrospection (ConSpec), can be added to any existing RL algorithm. ConSpec learns a set of prototypes for the critical steps in a task by a novel contrastive loss and delivers an intrinsic reward when the current state matches one of the prototypes. The prototypes in ConSpec provide two key benefits for credit assignment: (i) They enable rapid identification of all the critical steps. (ii) They do so in a readily interpretable manner, enabling out-of-distribution generalization when sensory features are altered. Distinct from other contemporary RL approaches to credit assignment, ConSpec takes advantage of the fact that it is easier to retrospectively identify the small set of steps that success is contingent upon (and ignoring other states) than it is to prospectively predict reward at every taken step. ConSpec greatly improves learning in a diverse set of RL tasks. The code is available at the link: https://github.com/sunchipsster1/ConSpec

Mehdi Azabou, Vinam Arora, Venkataramana Ganesh et al. · gatech

Our ability to use deep learning approaches to decipher neural activity would likely benefit from greater scale, in terms of both model size and datasets. However, the integration of many neural recordings into one unified model is challenging, as each recording contains the activity of different neurons from different individual animals. In this paper, we introduce a training framework and architecture designed to model the population dynamics of neural activity across diverse, large-scale neural recordings. Our method first tokenizes individual spikes within the dataset to build an efficient representation of neural events that captures the fine temporal structure of neural activity. We then employ cross-attention and a PerceiverIO backbone to further construct a latent tokenization of neural population activities. Utilizing this architecture and training framework, we construct a large-scale multi-session model trained on large datasets from seven nonhuman primates, spanning over 158 different sessions of recording from over 27,373 neural units and over 100 hours of recordings. In a number of different tasks, we demonstrate that our pretrained model can be rapidly adapted to new, unseen sessions with unspecified neuron correspondence, enabling few-shot performance with minimal labels. This work presents a powerful new approach for building deep learning tools to analyze neural data and stakes out a clear path to training at scale.

Anthony Zador, Jean-Marc Fellous, Terrence Sejnowski et al. · uw

Neuroscience and Artificial Intelligence (AI) have made impressive progress in recent years but remain only loosely interconnected. Based on a workshop convened by the National Science Foundation in August 2025, we identify three fundamental capability gaps in current AI: the inability to interact with the physical world, inadequate learning that produces brittle systems, and unsustainable energy and data inefficiency. We describe the neuroscience principles that address each: co-design of body and controller, prediction through interaction, multi-scale learning with neuromodulatory control, hierarchical distributed architectures, and sparse event-driven computation. We present a research roadmap organized around these principles at near, mid, and long-term horizons. We argue that realizing this program requires a new generation of researchers trained across the boundary between neuroscience and engineering, and describe the institutional conditions: interdisciplinary training, hardware access, community standards, and ethics, needed to support them. We conclude that NeuroAI, neuroscience-informed artificial intelligence, has the potential to overcome limitations of current AI while deepening our understanding of biological neural computation.

Giancarlo Kerg, Sarthak Mittal, David Rolnick et al.

Current deep learning approaches have shown good in-distribution generalization performance, but struggle with out-of-distribution generalization. This is especially true in the case of tasks involving abstract relations like recognizing rules in sequences, as we find in many intelligence tests. Recent work has explored how forcing relational representations to remain distinct from sensory representations, as it seems to be the case in the brain, can help artificial systems. Building on this work, we further explore and formalize the advantages afforded by 'partitioned' representations of relations and sensory details, and how this inductive bias can help recompose learned relational structure in newly encountered settings. We introduce a simple architecture based on similarity scores which we name Compositional Relational Network (CoRelNet). Using this model, we investigate a series of inductive biases that ensure abstract relations are learned and represented distinctly from sensory data, and explore their effects on out-of-distribution generalization for a series of relational psychophysics tasks. We find that simple architectural choices can outperform existing models in out-of-distribution generalization. Together, these results show that partitioning relational representations from other information streams may be a simple way to augment existing network architectures' robustness when performing out-of-distribution relational computations.

Vinam Arora, Divyansha Lachi, Ian J. Knight et al.

Neurons process information in ways that depend on their cell type, connectivity, and the brain region in which they are embedded. However, inferring these factors from neural activity remains a significant challenge. To build general-purpose representations that allow for resolving information about a neuron's identity, we introduce NuCLR, a self-supervised framework that aims to learn representations of neural activity that allow for differentiating one neuron from the rest. NuCLR brings together views of the same neuron observed at different times and across different stimuli and uses a contrastive objective to pull these representations together. To capture population context without assuming any fixed neuron ordering, we build a spatiotemporal transformer that integrates activity in a permutation-equivariant manner. Across multiple electrophysiology and calcium imaging datasets, a linear decoding evaluation on top of NuCLR representations achieves a new state-of-the-art for both cell type and brain region decoding tasks, and demonstrates strong zero-shot generalization to unseen animals. We present the first systematic scaling analysis for neuron-level representation learning, showing that increasing the number of animals used during pretraining consistently improves downstream performance. The learned representations are also label-efficient, requiring only a small fraction of labeled samples to achieve competitive performance. These results highlight how large, diverse neural datasets enable models to recover information about neuron identity that generalize across animals. Code is available at https://github.com/nerdslab/nuclr.

Yizi Zhang, Yanchen Wang, Donato Jimenez-Beneto et al. · gatech

Neuroscience research has made immense progress over the last decade, but our understanding of the brain remains fragmented and piecemeal: the dream of probing an arbitrary brain region and automatically reading out the information encoded in its neural activity remains out of reach. In this work, we build towards a first foundation model for neural spiking data that can solve a diverse set of tasks across multiple brain areas. We introduce a novel self-supervised modeling approach for population activity in which the model alternates between masking out and reconstructing neural activity across different time steps, neurons, and brain regions. To evaluate our approach, we design unsupervised and supervised prediction tasks using the International Brain Laboratory repeated site dataset, which is comprised of Neuropixels recordings targeting the same brain locations across 48 animals and experimental sessions. The prediction tasks include single-neuron and region-level activity prediction, forward prediction, and behavior decoding. We demonstrate that our multi-task-masking (MtM) approach significantly improves the performance of current state-of-the-art population models and enables multi-task learning. We also show that by training on multiple animals, we can improve the generalization ability of the model to unseen animals, paving the way for a foundation model of the brain at single-cell, single-spike resolution.

Karolis Jucys, George Adamopoulos, Mehrab Hamidi et al.

Understanding the mechanisms behind decisions taken by large foundation models in sequential decision making tasks is critical to ensuring that such systems operate transparently and safely. In this work, we perform exploratory analysis on the Video PreTraining (VPT) Minecraft playing agent, one of the largest open-source vision-based agents. We aim to illuminate its reasoning mechanisms by applying various interpretability techniques. First, we analyze the attention mechanism while the agent solves its training task - crafting a diamond pickaxe. The agent pays attention to the last four frames and several key-frames further back in its six-second memory. This is a possible mechanism for maintaining coherence in a task that takes 3-10 minutes, despite the short memory span. Secondly, we perform various interventions, which help us uncover a worrying case of goal misgeneralization: VPT mistakenly identifies a villager wearing brown clothes as a tree trunk when the villager is positioned stationary under green tree leaves, and punches it to death.

Josh Abramson, Arun Ahuja, Federico Carnevale et al.

Creating agents that can interact naturally with humans is a common goal in artificial intelligence (AI) research. However, evaluating these interactions is challenging: collecting online human-agent interactions is slow and expensive, yet faster proxy metrics often do not correlate well with interactive evaluation. In this paper, we assess the merits of these existing evaluation metrics and present a novel approach to evaluation called the Standardised Test Suite (STS). The STS uses behavioural scenarios mined from real human interaction data. Agents see replayed scenario context, receive an instruction, and are then given control to complete the interaction offline. These agent continuations are recorded and sent to human annotators to mark as success or failure, and agents are ranked according to the proportion of continuations in which they succeed. The resulting STS is fast, controlled, interpretable, and representative of naturalistic interactions. Altogether, the STS consolidates much of what is desirable across many of our standard evaluation metrics, allowing us to accelerate research progress towards producing agents that can interact naturally with humans. A video may be found at https://youtu.be/YR1TngGORGQ.

Raymond Chua, Doina Precup, Blake Richards

A hallmark of intelligence is the ability to adapt in non-stationary environments, yet deep Reinforcement Learning (RL) agents often struggle in such settings. Prior studies introduce non-stationarity through abrupt shifts in features or dynamics, whereas real-world environments often evolve gradually through continual drift. This distinction has important implications for the "stability-plasticity dilemma" in RL, as abrupt task changes may demand more plasticity than naturalistic settings. To address this, we modify existing 3D Miniworld and MuJoCo environments to incorporate naturalistic, continual non-stationarity, and use them to examine how stability and adaptation affect performance under continuous environmental change. We find that methods favoring stability, such as synaptic consolidation, outperform approaches focused on plasticity, such as parameters resetting. Motivated by this result, and prior evidence that Successor Features (SFs) reduce interference, we investigate whether SFs are better consolidation targets than Q-values. Across both environments, applying neuro-inspired synaptic consolidation to SFs yields superior performance on continually changing settings. Moreover, consolidation is most effective when SFs are stabilized across multiple timescales, which capture complementary aspects of gradual environmental change. Together, these results suggest that stability is more critical in continual learning when changes are gradual, and that multi-timescale consolidation of predictive representations is an effective approach.

Damjan Kalajdzievski, Ximeng Mao, Pascal Fortier-Poisson et al.

When presented with a data stream of two statistically dependent variables, predicting the future of one of the variables (the target stream) can benefit from information about both its history and the history of the other variable (the source stream). For example, fluctuations in temperature at a weather station can be predicted using both temperatures and barometric readings. However, a challenge when modelling such data is that it is easy for a neural network to rely on the greatest joint correlations within the target stream, which may ignore a crucial but small information transfer from the source to the target stream. As well, there are often situations where the target stream may have previously been modelled independently and it would be useful to use that model to inform a new joint model. Here, we develop an information bottleneck approach for conditional learning on two dependent streams of data. Our method, which we call Transfer Entropy Bottleneck (TEB), allows one to learn a model that bottlenecks the directed information transferred from the source variable to the target variable, while quantifying this information transfer within the model. As such, TEB provides a useful new information bottleneck approach for modelling two statistically dependent streams of data in order to make predictions about one of them.

Roy Henha Eyono, Daniel Levenstein, Arna Ghosh et al.

Normalization is a critical operation in neural circuits. In the brain, there is evidence that normalization is implemented via inhibitory interneurons and allows neural populations to adjust to changes in the distribution of their inputs. In artificial neural networks (ANNs), normalization is used to improve learning in tasks that involve complex input distributions. However, it is unclear whether inhibition-mediated normalization in biological neural circuits also improves learning. Here, we explore this possibility using ANNs with separate excitatory and inhibitory populations trained on an image recognition task with variable luminosity. We find that inhibition-mediated normalization does not improve learning if normalization is applied only during inference. However, when this normalization is extended to include back-propagated errors, performance improves significantly. These results suggest that if inhibition-mediated normalization improves learning in the brain, it additionally requires the normalization of learning signals.

David Raposo, Sam Ritter, Blake Richards et al.

Transformer-based language models spread FLOPs uniformly across input sequences. In this work we demonstrate that transformers can instead learn to dynamically allocate FLOPs (or compute) to specific positions in a sequence, optimising the allocation along the sequence for different layers across the model depth. Our method enforces a total compute budget by capping the number of tokens ($k$) that can participate in the self-attention and MLP computations at a given layer. The tokens to be processed are determined by the network using a top-$k$ routing mechanism. Since $k$ is defined a priori, this simple procedure uses a static computation graph with known tensor sizes, unlike other conditional computation techniques. Nevertheless, since the identities of the $k$ tokens are fluid, this method can expend FLOPs non-uniformly across the time and model depth dimensions. Thus, compute expenditure is entirely predictable in sum total, but dynamic and context-sensitive at the token-level. Not only do models trained in this way learn to dynamically allocate compute, they do so efficiently. These models match baseline performance for equivalent FLOPS and wall-clock times to train, but require a fraction of the FLOPs per forward pass, and can be upwards of 50\% faster to step during post-training sampling.

Kumar Krishna Agrawal, Arna Ghosh, Shagun Sodhani et al.

Recent progress in self-supervised (SSL) visual representation learning has led to the development of several different proposed frameworks that rely on augmentations of images but use different loss functions. However, there are few theoretically grounded principles to guide practice, so practical implementation of each SSL framework requires several heuristics to achieve competitive performance. In this work, we build on recent analytical results to design practical recommendations for competitive and efficient SSL that are grounded in theory. Specifically, recent theory tells us that existing SSL frameworks are minimizing the same idealized loss, which is to learn features that best match the data similarity kernel defined by the augmentations used. We show how this idealized loss can be reformulated to a functionally equivalent loss that is more efficient to compute. We study the implicit bias of using gradient descent to minimize our reformulated loss function and find that using a stronger orthogonalization constraint with a reduced projector dimensionality should yield good representations. Furthermore, the theory tells us that approximating the reformulated loss should be improved by increasing the number of augmentations, and as such using multiple augmentations should lead to improved convergence. We empirically verify our findings on CIFAR, STL and Imagenet datasets, wherein we demonstrate an improved linear readout performance when training a ResNet-backbone using our theoretically grounded recommendations. Remarkably, we also demonstrate that by leveraging these insights, we can reduce the pretraining dataset size by up to 2$\times$ while maintaining downstream accuracy simply by using more data augmentations. Taken together, our work provides theoretically grounded recommendations that can be used to improve SSL convergence and efficiency.

Alexander Meulemans, Seijin Kobayashi, Johannes von Oswald et al.

Self-interested individuals often fail to cooperate, posing a fundamental challenge for multi-agent learning. How can we achieve cooperation among self-interested, independent learning agents? Promising recent work has shown that in certain tasks cooperation can be established between learning-aware agents who model the learning dynamics of each other. Here, we present the first unbiased, higher-derivative-free policy gradient algorithm for learning-aware reinforcement learning, which takes into account that other agents are themselves learning through trial and error based on multiple noisy trials. We then leverage efficient sequence models to condition behavior on long observation histories that contain traces of the learning dynamics of other agents. Training long-context policies with our algorithm leads to cooperative behavior and high returns on standard social dilemmas, including a challenging environment where temporally-extended action coordination is required. Finally, we derive from the iterated prisoner's dilemma a novel explanation for how and when cooperation arises among self-interested learning-aware agents.

Alexander Meulemans, Rajai Nasser, Maciej Wołczyk et al.

The standard theory of model-free reinforcement learning assumes that the environment dynamics are stationary and that agents are decoupled from their environment, such that policies are treated as being separate from the world they inhabit. This leads to theoretical challenges in the multi-agent setting where the non-stationarity induced by the learning of other agents demands prospective learning based on prediction models. To accurately model other agents, an agent must account for the fact that those other agents are, in turn, forming beliefs about it to predict its future behavior, motivating agents to model themselves as part of the environment. Here, building upon foundational work on universal artificial intelligence (AIXI), we introduce a mathematical framework for prospective learning and embedded agency centered on self-prediction, where Bayesian RL agents predict both future perceptual inputs and their own actions, and must therefore resolve epistemic uncertainty about themselves as part of the universe they inhabit. We show that in multi-agent settings, self-prediction enables agents to reason about others running similar algorithms, leading to new game-theoretic solution concepts and novel forms of cooperation unattainable by classical decoupled agents. Moreover, we extend the theory of AIXI, and study universally intelligent embedded agents which start from a Solomonoff prior. We show that these idealized agents can form consistent mutual predictions and achieve infinite-order theory of mind, potentially setting a gold standard for embedded multi-agent learning.

Sangyoon Bae, Mehdi Azabou, Jiook Cha et al. · gatech

Self-supervised learning (SSL) holds a great deal of promise for applications in neuroscience, due to the lack of large-scale, consistently labeled neural datasets. However, most neural datasets contain heterogeneous populations that mix stable, predictable cells with highly stochastic, stimulus-contingent ones, which has made it hard to identify consistent activity patterns during SSL. As a result, self-supervised pretraining has yet to show clear signs of benefits from scale on neural data. Here, we present a novel approach to self-supervised pretraining, POYO-SSL that exploits the heterogeneity of neural data to improve pre-training and achieve benefits of scale. Specifically, in POYO-SSL we pretrain only on predictable (statistically regular) neurons-identified on the pretraining split via simple higher-order statistics (skewness and kurtosis)-then we fine-tune on the unpredictable population for downstream tasks. On the Allen Brain Observatory dataset, this strategy yields approximately 12-13% relative gains over from-scratch training and exhibits smooth, monotonic scaling with model size. In contrast, existing state-of-the-art baselines plateau or destabilize as model size increases. By making predictability an explicit metric for crafting the data diet, POYO-SSL turns heterogeneity from a liability into an asset, providing a robust, biologically grounded recipe for scalable neural decoding and a path toward foundation models of neural dynamics.

Roman Pogodin, Jonathan Cornford, Arna Ghosh et al.

A growing literature in computational neuroscience leverages gradient descent and learning algorithms that approximate it to study synaptic plasticity in the brain. However, the vast majority of this work ignores a critical underlying assumption: the choice of distance for synaptic changes - i.e. the geometry of synaptic plasticity. Gradient descent assumes that the distance is Euclidean, but many other distances are possible, and there is no reason that biology necessarily uses Euclidean geometry. Here, using the theoretical tools provided by mirror descent, we show that the distribution of synaptic weights will depend on the geometry of synaptic plasticity. We use these results to show that experimentally-observed log-normal weight distributions found in several brain areas are not consistent with standard gradient descent (i.e. a Euclidean geometry), but rather with non-Euclidean distances. Finally, we show that it should be possible to experimentally test for different synaptic geometries by comparing synaptic weight distributions before and after learning. Overall, our work shows that the current paradigm in theoretical work on synaptic plasticity that assumes Euclidean synaptic geometry may be misguided and that it should be possible to experimentally determine the true geometry of synaptic plasticity in the brain.

Arna Ghosh, Arnab Kumar Mondal, Kumar Krishna Agrawal et al.

Representation learning that leverages large-scale labelled datasets, is central to recent progress in machine learning. Access to task relevant labels at scale is often scarce or expensive, motivating the need to learn from unlabelled datasets with self-supervised learning (SSL). Such large unlabelled datasets (with data augmentations) often provide a good coverage of the underlying input distribution. However evaluating the representations learned by SSL algorithms still requires task-specific labelled samples in the training pipeline. Additionally, the generalization of task-specific encoding is often sensitive to potential distribution shift. Inspired by recent advances in theoretical machine learning and vision neuroscience, we observe that the eigenspectrum of the empirical feature covariance matrix often follows a power law. For visual representations, we estimate the coefficient of the power law, $α$, across three key attributes which influence representation learning: learning objective (supervised, SimCLR, Barlow Twins and BYOL), network architecture (VGG, ResNet and Vision Transformer), and tasks (object and scene recognition). We observe that under mild conditions, proximity of $α$ to 1, is strongly correlated to the downstream generalization performance. Furthermore, $α\approx 1$ is a strong indicator of robustness to label noise during fine-tuning. Notably, $α$ is computable from the representations without knowledge of any labels, thereby offering a framework to evaluate the quality of representations in unlabelled datasets.

Maxence Ernoult, Fabrice Normandin, Abhinav Moudgil et al.

The development of biologically-plausible learning algorithms is important for understanding learning in the brain, but most of them fail to scale-up to real-world tasks, limiting their potential as explanations for learning by real brains. As such, it is important to explore learning algorithms that come with strong theoretical guarantees and can match the performance of backpropagation (BP) on complex tasks. One such algorithm is Difference Target Propagation (DTP), a biologically-plausible learning algorithm whose close relation with Gauss-Newton (GN) optimization has been recently established. However, the conditions under which this connection rigorously holds preclude layer-wise training of the feedback pathway synaptic weights (which is more biologically plausible). Moreover, good alignment between DTP weight updates and loss gradients is only loosely guaranteed and under very specific conditions for the architecture being trained. In this paper, we propose a novel feedback weight training scheme that ensures both that DTP approximates BP and that layer-wise feedback weight training can be restored without sacrificing any theoretical guarantees. Our theory is corroborated by experimental results and we report the best performance ever achieved by DTP on CIFAR-10 and ImageNet 32$\times$32

Nicholas Roy, Ingmar Posner, Tim Barfoot et al.

Machine learning has long since become a keystone technology, accelerating science and applications in a broad range of domains. Consequently, the notion of applying learning methods to a particular problem set has become an established and valuable modus operandi to advance a particular field. In this article we argue that such an approach does not straightforwardly extended to robotics -- or to embodied intelligence more generally: systems which engage in a purposeful exchange of energy and information with a physical environment. In particular, the purview of embodied intelligent agents extends significantly beyond the typical considerations of main-stream machine learning approaches, which typically (i) do not consider operation under conditions significantly different from those encountered during training; (ii) do not consider the often substantial, long-lasting and potentially safety-critical nature of interactions during learning and deployment; (iii) do not require ready adaptation to novel tasks while at the same time (iv) effectively and efficiently curating and extending their models of the world through targeted and deliberate actions. In reality, therefore, these limitations result in learning-based systems which suffer from many of the same operational shortcomings as more traditional, engineering-based approaches when deployed on a robot outside a well defined, and often narrow operating envelope. Contrary to viewing embodied intelligence as another application domain for machine learning, here we argue that it is in fact a key driver for the advancement of machine learning technology. In this article our goal is to highlight challenges and opportunities that are specific to embodied intelligence and to propose research directions which may significantly advance the state-of-the-art in robot learning.