Jianhua Ma

Guanqun Sun, Yizhi Pan, Weikun Kong et al.

Accurate medical image segmentation is critical for disease quantification and treatment evaluation. While traditional Unet architectures and their transformer-integrated variants excel in automated segmentation tasks. However, they lack the ability to harness the intrinsic position and channel features of image. Existing models also struggle with parameter efficiency and computational complexity, often due to the extensive use of Transformers. To address these issues, this study proposes a novel deep medical image segmentation framework, called DA-TransUNet, aiming to integrate the Transformer and dual attention block(DA-Block) into the traditional U-shaped architecture. Unlike earlier transformer-based U-net models, DA-TransUNet utilizes Transformers and DA-Block to integrate not only global and local features, but also image-specific positional and channel features, improving the performance of medical image segmentation. By incorporating a DA-Block at the embedding layer and within each skip connection layer, we substantially enhance feature extraction capabilities and improve the efficiency of the encoder-decoder structure. DA-TransUNet demonstrates superior performance in medical image segmentation tasks, consistently outperforming state-of-the-art techniques across multiple datasets. In summary, DA-TransUNet offers a significant advancement in medical image segmentation, providing an effective and powerful alternative to existing techniques. Our architecture stands out for its ability to improve segmentation accuracy, thereby advancing the field of automated medical image diagnostics. The codes and parameters of our model will be publicly available at https://github.com/SUN-1024/DA-TransUnet.

Weiguo Cao, Marc J. Pomeroy, Zhengrong Liang et al.

The elasticity of soft tissues has been widely considered as a characteristic property to differentiate between healthy and vicious tissues and, therefore, motivated several elasticity imaging modalities, such as Ultrasound Elastography, Magnetic Resonance Elastography, and Optical Coherence Elastography. This paper proposes an alternative approach of modeling the elasticity using Computed Tomography (CT) imaging modality for model-based feature extraction machine learning (ML) differentiation of lesions. The model describes a dynamic non-rigid (or elastic) deformation in differential manifold to mimic the soft tissues elasticity under wave fluctuation in vivo. Based on the model, three local deformation invariants are constructed by two tensors defined by the first and second order derivatives from the CT images and used to generate elastic feature maps after normalization via a novel signal suppression method. The model-based elastic image features are extracted from the feature maps and fed to machine learning to perform lesion classifications. Two pathologically proven image datasets of colon polyps (44 malignant and 43 benign) and lung nodules (46 malignant and 20 benign) were used to evaluate the proposed model-based lesion classification. The outcomes of this modeling approach reached the score of area under the curve of the receiver operating characteristics of 94.2 % for the polyps and 87.4 % for the nodules, resulting in an average gain of 5 % to 30 % over ten existing state-of-the-art lesion classification methods. The gains by modeling tissue elasticity for ML differentiation of lesions are striking, indicating the great potential of exploring the modeling strategy to other tissue properties for ML differentiation of lesions.