Lihua Guo

Qi Ye, Lihua Guo

In recent years, "U-shaped" neural networks featuring encoder and decoder structures have gained popularity in the field of medical image segmentation. Various variants of this model have been developed. Nevertheless, the evaluation of these models has received less attention compared to model development. In response, we propose a comprehensive method for evaluating medical image segmentation models for multi-indicator and multi-organ (named MIMO). MIMO allows models to generate independent thresholds which are then combined with multi-indicator evaluation and confidence estimation to screen and measure each organ. As a result, MIMO offers detailed information on the segmentation of each organ in each sample, thereby aiding developers in analyzing and improving the model. Additionally, MIMO can produce concise usability and comprehensiveness scores for different models. Models with higher scores are deemed to be excellent models, which is convenient for clinical evaluation. Our research tests eight different medical image segmentation models on two abdominal multi-organ datasets and evaluates them from four perspectives: correctness, confidence estimation, Usable Region and MIMO. Furthermore, robustness experiments are tested. Experimental results demonstrate that MIMO offers novel insights into multi-indicator and multi-organ medical image evaluation and provides a specific and concise measure for the usability and comprehensiveness of the model. Code: https://github.com/SCUT-ML-GUO/MIMO

Kangjun Liu, Ke Chen, Lihua Guo et al.

Mixup style data augmentation algorithms have been widely adopted in various tasks as implicit network regularization on representation learning to improve model generalization, which can be achieved by a linear interpolation of labeled samples in input or feature space as well as target space. Inspired by good robustness of alternative dropout strategies against over-fitting on limited patterns of training samples, this paper introduces a novel concept of ShuffleMix -- Shuffle of Mixed hidden features, which can be interpreted as a kind of dropout operation in feature space. Specifically, our ShuffleMix method favors a simple linear shuffle of randomly selected feature channels for feature mixup in-between training samples to leverage semantic interpolated supervision signals, which can be extended to a generalized shuffle operation via additionally combining linear interpolations of intra-channel features. Compared to its direct competitor of feature augmentation -- the Manifold Mixup, the proposed ShuffleMix can gain superior generalization, owing to imposing more flexible and smooth constraints on generating samples and achieving regularization effects of channel-wise feature dropout. Experimental results on several public benchmarking datasets of single-label and multi-label visual classification tasks can confirm the effectiveness of our method on consistently improving representations over the state-of-the-art mixup augmentation.

Yu Xiao, Xin Yang, Sijuan Huang et al.

Medical image segmentation is particularly critical as a prerequisite for relevant quantitative analysis in the treatment of clinical diseases. For example, in clinical cervical cancer radiotherapy, after acquiring subabdominal MRI images, a fast and accurate image segmentation of organs and tumors in MRI images can optimize the clinical radiotherapy process, whereas traditional approaches use manual annotation by specialist doctors, which is time-consuming and laborious, therefore, automatic organ segmentation of subabdominal MRI images is a valuable research topic.

Zexi Huang, Lihua Guo, Xin Yang et al.

Nasopharyngeal carcinoma (NPC) is a kind of malignant tumor. Accurate and automatic segmentation of organs at risk (OAR) of computed tomography (CT) images is clinically significant. In recent years, deep learning models represented by U-Net have been widely applied in medical image segmentation tasks, which can help doctors with reduction of workload and get accurate results more quickly. In OAR segmentation of NPC, the sizes of OAR are variable, especially, some of them are small. Traditional deep neural networks underperform during segmentation due to the lack use of global and multi-size information. This paper proposes a new SE-Connection Pyramid Network (SECP-Net). SECP-Net extracts global and multi-size information flow with se connection (SEC) modules and a pyramid structure of network for improving the segmentation performance, especially that of small organs. SECP-Net also designs an auto-context cascaded network to further improve the segmentation performance. Comparative experiments are conducted between SECP-Net and other recently methods on a dataset with CT images of head and neck. Five-fold cross validation is used to evaluate the performance based on two metrics, i.e., Dice and Jaccard similarity. Experimental results show that SECP-Net can achieve SOTA performance in this challenging task.