Ziqi Deng

Yusi Fan, Tian Wang, Zhiying Yan et al.

Feature selection is a combinatorial optimization problem that is NP-hard. Conventional approaches often employ heuristic or greedy strategies, which are prone to premature convergence and may fail to capture subtle yet informative features. This limitation becomes especially critical in high-dimensional datasets, where complex and interdependent feature relationships prevail. We introduce the HeFS (Helper-Enhanced Feature Selection) framework to refine feature subsets produced by existing algorithms. HeFS systematically searches the residual feature space to identify a Helper Set - features that complement the original subset and improve classification performance. The approach employs a biased initialization scheme and a ratio-guided mutation mechanism within a genetic algorithm, coupled with Pareto-based multi-objective optimization to jointly maximize predictive accuracy and feature complementarity. Experiments on 18 benchmark datasets demonstrate that HeFS consistently identifies overlooked yet informative features and achieves superior performance over state-of-the-art methods, including in challenging domains such as gastric cancer classification, drug toxicity prediction, and computer science applications. The code and datasets are available at https://healthinformaticslab.org/supp/.

Li Ni, Ziqi Deng, Lin Mu et al.

Hypergraphs, capable of representing high-order interactions via hyperedges, have become a powerful tool for modeling real-world biological and social systems. Inherent relationships within these real-world systems, such as the encoding relationship between genes and their protein products, drive the establishment of interconnections between multiple hypergraphs. Here, we demonstrate how to utilize those interconnections between multiple hypergraphs to synthesize integrated information from multiple higher-order systems, thereby enhancing understanding of underlying structures. We propose a model based on the stochastic block model, which integrates information from multiple hypergraphs to reveal latent high-order structures. Real-world hyperedges exhibit preferential attachment, where certain nodes dominate hyperedge formation. To characterize this phenomenon, our model introduces hyperedge internal degree to quantify nodes' contributions to hyperedge formation. This model is capable of mining communities, predicting missing hyperedges of arbitrary sizes within hypergraphs, and inferring inter-hypergraph edges between hypergraphs. We apply our model to high-order datasets to evaluate its performance. Experimental results demonstrate strong performance of our model in community detection, hyperedge prediction, and inter-hypergraph edge prediction tasks. Moreover, we show that our model enables analysis of multiple hypergraphs of different types and supports the analysis of a single hypergraph in the absence of inter-hypergraph edges. Our work provides a practical and flexible tool for analyzing multiple hypergraphs, greatly advancing the understanding of the organization in real-world high-order systems.

Ruochi Zhang, Qian Yang, Xiaoyang Wang et al.

The rapid accumulation of Electronic Health Records (EHRs) has transformed healthcare by providing valuable data that enhance clinical predictions and diagnoses. While conventional machine learning models have proven effective, they often lack robust representation learning and depend heavily on expert-crafted features. Although deep learning offers powerful solutions, it is often criticized for its lack of interpretability. To address these challenges, we propose DeepSelective, a novel end to end deep learning framework for predicting patient prognosis using EHR data, with a strong emphasis on enhancing model interpretability. DeepSelective combines data compression techniques with an innovative feature selection approach, integrating custom-designed modules that work together to improve both accuracy and interpretability. Our experiments demonstrate that DeepSelective not only enhances predictive accuracy but also significantly improves interpretability, making it a valuable tool for clinical decision-making. The source code is freely available at http://www.healthinformaticslab.org/supp/resources.php .