Han Chen

Chen Han, Wenzhen Zheng, Xijin Tang

The proliferation of misinformation in digital platforms reveals the limitations of traditional detection methods, which mostly rely on static classification and fail to capture the intricate process of real-world fact-checking. Despite advancements in Large Language Models (LLMs) that enhance automated reasoning, their application to misinformation detection remains hindered by issues of logical inconsistency and superficial verification. In response, we introduce Debate-to-Detect (D2D), a novel Multi-Agent Debate (MAD) framework that reformulates misinformation detection as a structured adversarial debate. Inspired by fact-checking workflows, D2D assigns domain-specific profiles to each agent and orchestrates a five-stage debate process, including Opening Statement, Rebuttal, Free Debate, Closing Statement, and Judgment. To transcend traditional binary classification, D2D introduces a multi-dimensional evaluation mechanism that assesses each claim across five distinct dimensions: Factuality, Source Reliability, Reasoning Quality, Clarity, and Ethics. Experiments with GPT-4o on two datasets demonstrate significant improvements over baseline methods, and the case study highlight D2D's capability to iteratively refine evidence while improving decision transparency, representing a substantial advancement towards interpretable misinformation detection. The code will be released publicly after the official publication.

Liang Xu, Pengwu Song, Shilu Zhu et al.

Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. To address this issue, a Vessel Connectivity Network (VC-Net) was developed for label-free assessment of vascular connectivity. To validate the VC-Net, microvascular networks (MVNs) were cultured in vitro and their microscopic images were acquired at different culturing conditions as a training dataset. The VC-Net employs a Vessel Queue Contrastive Learning (VQCL) method and a class imbalance algorithm to address the issues of limited sample size, indistinctive class features and imbalanced class distribution in the dataset. The VC-Net successfully evaluated the vascular connectivity with no significant deviation from that by fluorescence imaging. In addition, the proposed VC-Net successfully differentiated the connectivity characteristics between normal and tumor-related MVNs. In comparison with those cultured in the regular microenvironment, the averaged connectivity of MVNs cultured in the tumor-related microenvironment decreased by 30.8%, whereas the non-connected area increased by 37.3%. This study provides a new avenue for label-free and continuous assessment of organoid or tumor vascularization in vitro.