Shuai Wang

Zipei Yan, Zhile Liang, Zhengji Liu et al.

High myopia significantly increases the risk of irreversible vision loss. Traditional perimetry-based visual field (VF) assessment provides systematic quantification of visual loss but it is subjective and time-consuming. Consequently, machine learning models utilizing fundus photographs to estimate VF have emerged as promising alternatives. However, due to the high variability and the limited availability of VF data, existing VF estimation models fail to generalize well, particularly when facing out-of-distribution data across diverse centers and populations. To tackle this challenge, we propose a novel, parameter-efficient framework to enhance the generalized robustness of VF estimation on both in- and out-of-distribution data. Specifically, we design a Refinement-by-Denoising (RED) module for feature refinement and adaptation from pretrained vision models, aiming to learn high-entropy feature representations and to mitigate the domain gap effectively and efficiently. Through independent validation on two distinct real-world datasets from separate centers, our method significantly outperforms existing approaches in RMSE, MAE and correlation coefficient for both internal and external validation. Our proposed framework benefits both in- and out-of-distribution VF estimation, offering significant clinical implications and potential utility in real-world ophthalmic practices.

Zhenlan Ji, Daoyuan Wu, Wenxuan Wang et al.

Function calling (FC) has emerged as a powerful technique for facilitating large language models (LLMs) to interact with external systems and perform structured tasks. However, the mechanisms through which it influences model behavior remain largely under-explored. Besides, we discover that in addition to the regular usage of FC, this technique can substantially enhance the compliance of LLMs with user instructions. These observations motivate us to leverage causality, a canonical analysis method, to investigate how FC works within LLMs. In particular, we conduct layer-level and token-level causal interventions to dissect FC's impact on the model's internal computational logic when responding to user queries. Our analysis confirms the substantial influence of FC and reveals several in-depth insights into its mechanisms. To further validate our findings, we conduct extensive experiments comparing the effectiveness of FC-based instructions against conventional prompting methods. We focus on enhancing LLM safety robustness, a critical LLM application scenario, and evaluate four mainstream LLMs across two benchmark datasets. The results are striking: FC shows an average performance improvement of around 135% over conventional prompting methods in detecting malicious inputs, demonstrating its promising potential to enhance LLM reliability and capability in practical applications.