Yin Wang

Eduardo Conde-Sousa, João Vale, Ming Feng et al.

Breast cancer is the most common malignancy in women, being responsible for more than half a million deaths every year. As such, early and accurate diagnosis is of paramount importance. Human expertise is required to diagnose and correctly classify breast cancer and define appropriate therapy, which depends on the evaluation of the expression of different biomarkers such as the transmembrane protein receptor HER2. This evaluation requires several steps, including special techniques such as immunohistochemistry or in situ hybridization to assess HER2 status. With the goal of reducing the number of steps and human bias in diagnosis, the HEROHE Challenge was organized, as a parallel event of the 16th European Congress on Digital Pathology, aiming to automate the assessment of the HER2 status based only on hematoxylin and eosin stained tissue sample of invasive breast cancer. Methods to assess HER2 status were presented by 21 teams worldwide and the results achieved by some of the proposed methods open potential perspectives to advance the state-of-the-art.

Siwei Yang, Shaozuo Yu, Bingchen Zhao et al.

Visual pattern recognition over agricultural areas is an important application of aerial image processing. In this paper, we consider the multi-modality nature of agricultural aerial images and show that naively combining different modalities together without taking the feature divergence into account can lead to sub-optimal results. Thus, we apply a Switchable Normalization block to our DeepLabV3 segmentation model to alleviate the feature divergence. Using the popular symmetric Kullback Leibler divergence measure, we show that our model can greatly reduce the divergence between RGB and near-infrared channels. Together with a hybrid loss function, our model achieves nearly 10\% improvements in mean IoU over previously published baseline.

Hui Chen, Fangqing Liu, Yin Wang et al.

Learning binary classifiers only from positive and unlabeled (PU) data is an important and challenging task in many real-world applications, including web text classification, disease gene identification and fraud detection, where negative samples are difficult to verify experimentally. Most recent PU learning methods are developed based on the conventional misclassification risk of the supervised learning type, and they require to solve the intractable risk estimation problem by approximating the negative data distribution or the class prior. In this paper, we introduce a variational principle for PU learning that allows us to quantitatively evaluate the modeling error of the Bayesian classifier directly from given data. This leads to a loss function which can be efficiently calculated without any intermediate step or model, and a variational learning method can then be employed to optimize the classifier under general conditions. In addition, the discriminative performance and numerical stability of the variational PU learning method can be further improved by incorporating a margin maximizing loss function. We illustrate the effectiveness of the proposed variational method on a number of benchmark examples.