Jiawen Li

Minghao Xu, Yuanfan Guo, Xuanyu Zhu et al.

Learning self-supervised image representations has been broadly studied to boost various visual understanding tasks. Existing methods typically learn a single level of image semantics like pairwise semantic similarity or image clustering patterns. However, these methods can hardly capture multiple levels of semantic information that naturally exists in an image dataset, e.g., the semantic hierarchy of "Persian cat to cat to mammal" encoded in an image database for species. It is thus unknown whether an arbitrary image self-supervised learning (SSL) approach can benefit from learning such hierarchical semantics. To answer this question, we propose a general framework for Hierarchical Image Representation Learning (HIRL). This framework aims to learn multiple semantic representations for each image, and these representations are structured to encode image semantics from fine-grained to coarse-grained. Based on a probabilistic factorization, HIRL learns the most fine-grained semantics by an off-the-shelf image SSL approach and learns multiple coarse-grained semantics by a novel semantic path discrimination scheme. We adopt six representative image SSL methods as baselines and study how they perform under HIRL. By rigorous fair comparison, performance gain is observed on all the six methods for diverse downstream tasks, which, for the first time, verifies the general effectiveness of learning hierarchical image semantics. All source code and model weights are available at https://github.com/hirl-team/HIRL

Shi Jinxin, Zhao Jiabao, Wang Yilei et al.

Benefiting from the powerful capabilities of large language models (LLMs), agents based on LLMs have shown the potential to address domain-specific tasks and emulate human behaviors. However, the content generated by these agents remains somewhat superficial, owing to their limited domain expertise and the absence of an effective cognitive architecture. To address this, we present the Configurable General Multi-Agent Interaction (CGMI) framework, designed to replicate human interactions in real-world scenarios. Specifically, we propose a tree-structured methodology for the assignment, detection, and maintenance of agent personality. Additionally, we designed a cognitive architecture equipped with a skill library based on the ACT* model, which contains memory, reflection, and planning modules. We have also integrated general agents to augment the virtual environment's realism. Using the CGMI framework, we simulated numerous classroom interactions between teacher and students. The experiments indicate that aspects such as the teaching methodology, curriculum, and student performance closely mirror real classroom settings. We will open source our work.

Xinyi Guo, Mingyi He, Haobin Ding et al.

Implicit neural representations (INRs) encode images as neural-network weights, making image classification a problem of weight-space classifiability. A natural geometric hypothesis is that classifier feedback should make image-specific weights cluster by class in the shared-anchor coordinate. We test this hypothesis in the SIREN-based Meta Weight Transformer (MWT) regime, where end-to-end training meta-learns a shared initialization and inner-loop update schedule for fitting image-specific SIRENs. We find that this prediction fails. Exposed weight-space geometry and supervised clustering pressure do not reliably track trained-reader accuracy; clustering can even make local neighborhoods more class-consistent while making the trained reader worse. Crucially, the reader constructs rather than inherits class-aligned geometry: token-flow diagnostics show that class-aligned neighborhoods become strongly predictive of trained-reader accuracy only after late reader interactions, not in the input coordinate. We further identify the native SIREN bias column in the augmented weight token as a low-dimensional, sample-dependent causal readout route for the trained reader; targeted controls rule out generic scalar-column and marginal-distribution artifacts. The diagnosis motivates interventions that strengthen reader routing, add an explicit bias route, or use denser inner-loop fitting; under the lane-specific training conventions used here, route-directed variants often outperform the shared-anchor baseline but interact non-additively. Task-induced INR weights are classifiable not because they form raw geometric clusters, but because their class signal is routed through the reader.

Qiehe Sun, Jiawen Li, Jin Xu et al.

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology diagnosis. However, existing methods tend to focus on advanced aggregators with different structures, often overlooking the intrinsic features of H\&E pathological slides. To address this limitation, we introduced two pathological priors: nuclear heterogeneity of diseased cells and spatial correlation of pathological tiles. Leveraging the former, we proposed a data augmentation method that utilizes stain separation during extractor training via a contrastive learning strategy to obtain instance-level representations. We then described the spatial relationships between the tiles using an adjacency matrix. By integrating these two views, we designed a multi-instance framework for analyzing H\&E-stained tissue images based on pathological inductive bias, encompassing feature extraction, filtering, and aggregation. Extensive experiments on the Camelyon16 breast dataset and TCGA-NSCLC Lung dataset demonstrate that our proposed framework can effectively handle tasks related to cancer detection and differentiation of subtypes, outperforming state-of-the-art medical image classification methods based on MIL. The code will be released later.

Hongbo Chu, Qiehe Sun, Jiawen Li et al.

Histopathological whole slide image (WSI) analysis with deep learning has become a research focus in computational pathology. The current paradigm is mainly based on multiple instance learning (MIL), in which approaches with Transformer as the backbone are well discussed. These methods convert WSI tasks into sequence tasks by representing patches as tokens in the WSI sequence. However, the feature complexity brought by high heterogeneity and the ultra-long sequences brought by gigapixel size makes Transformer-based MIL suffer from the challenges of high memory consumption, slow inference speed, and lack of performance. To this end, we propose a retentive MIL method called RetMIL, which processes WSI sequences through hierarchical feature propagation structure. At the local level, the WSI sequence is divided into multiple subsequences. Tokens of each subsequence are updated through a parallel linear retention mechanism and aggregated utilizing an attention layer. At the global level, subsequences are fused into a global sequence, then updated through a serial retention mechanism, and finally the slide-level representation is obtained through a global attention pooling. We conduct experiments on two public CAMELYON and BRACS datasets and an public-internal LUNG dataset, confirming that RetMIL not only achieves state-of-the-art performance but also significantly reduces computational overhead. Our code will be accessed shortly.

Lequan Lin, Dai Shi, Andi Han et al.

Supervised learning relies on high-quality labeled data, but obtaining such data through human annotation is both expensive and time-consuming. Recent work explores using large language models (LLMs) for annotation, but LLM-generated labels still fall short of human-level quality. To address this problem, we propose the Annotation with Critical Thinking (ACT) data pipeline, where LLMs serve not only as annotators but also as judges to critically identify potential errors. Human effort is then directed towards reviewing only the most "suspicious" cases, significantly improving the human annotation efficiency. Our major contributions are as follows: (1) ACT is applicable to a wide range of domains, including natural language processing (NLP), computer vision (CV), and multimodal understanding, by leveraging multimodal-LLMs (MLLMs). (2) Through empirical studies, we derive 7 insights on how to enhance annotation quality while efficiently reducing the human cost, and then translate these findings into user-friendly guidelines. (3) We theoretically analyze how to modify the loss function so that models trained on ACT data achieve similar performance to those trained on fully human-annotated data. Our experiments show that the performance gap can be reduced to less than 2% on most benchmark datasets while saving up to 90% of human costs.

Xitong Ling, Yuanyuan Lei, Jiawen Li et al.

Advances in optical microscopy scanning have significantly contributed to computational pathology (CPath) by converting traditional histopathological slides into whole slide images (WSIs). This development enables comprehensive digital reviews by pathologists and accelerates AI-driven diagnostic support for WSI analysis. Recent advances in foundational pathology models have increased the need for benchmarking tasks. The Camelyon series is one of the most widely used open-source datasets in computational pathology. However, the quality, accessibility, and clinical relevance of the labels have not been comprehensively evaluated. In this study, we reprocessed 1,399 WSIs and labels from the Camelyon-16 and Camelyon-17 datasets, removing low-quality slides, correcting erroneous labels, and providing expert pixel annotations for tumor regions in the previously unreleased test set. Based on the sizes of re-annotated tumor regions, we upgraded the binary cancer screening task to a four-class task: negative, micro-metastasis, macro-metastasis, and Isolated Tumor Cells (ITC). We reevaluated pre-trained pathology feature extractors and multiple instance learning (MIL) methods using the cleaned dataset, providing a benchmark that advances AI development in histopathology.

Yuanfan Guo, Minghao Xu, Jiawen Li et al.

Hierarchical semantic structures naturally exist in an image dataset, in which several semantically relevant image clusters can be further integrated into a larger cluster with coarser-grained semantics. Capturing such structures with image representations can greatly benefit the semantic understanding on various downstream tasks. Existing contrastive representation learning methods lack such an important model capability. In addition, the negative pairs used in these methods are not guaranteed to be semantically distinct, which could further hamper the structural correctness of learned image representations. To tackle these limitations, we propose a novel contrastive learning framework called Hierarchical Contrastive Selective Coding (HCSC). In this framework, a set of hierarchical prototypes are constructed and also dynamically updated to represent the hierarchical semantic structures underlying the data in the latent space. To make image representations better fit such semantic structures, we employ and further improve conventional instance-wise and prototypical contrastive learning via an elaborate pair selection scheme. This scheme seeks to select more diverse positive pairs with similar semantics and more precise negative pairs with truly distinct semantics. On extensive downstream tasks, we verify the superior performance of HCSC over state-of-the-art contrastive methods, and the effectiveness of major model components is proved by plentiful analytical studies. We build a comprehensive model zoo in Sec. D. Our source code and model weights are available at https://github.com/gyfastas/HCSC

Jiawen Li, Qiehe Sun, Renao Yan et al. · tsinghua

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level annotation, current research primarily focuses on representation learning with slide-level labels, showing success in various downstream tasks. However, given the diversity of lesion types and the complex relationships between each other, these techniques still deserve further exploration in addressing advanced pathology tasks. To this end, we introduce the concept of hierarchical pathological image classification and propose a representation learning called PathTree. PathTree considers the multi-classification of diseases as a binary tree structure. Each category is represented as a professional pathological text description, which messages information with a tree-like encoder. The interactive text features are then used to guide the aggregation of hierarchical multiple representations. PathTree uses slide-text similarity to obtain probability scores and introduces two extra tree specific losses to further constrain the association between texts and slides. Through extensive experiments on three challenging hierarchical classification datasets: in-house cryosectioned lung tissue lesion identification, public prostate cancer grade assessment, and public breast cancer subtyping, our proposed PathTree is consistently competitive compared to the state-of-the-art methods and provides a new perspective on the deep learning-assisted solution for more complex WSI classification.

Rongjun Chen, Chengsi Yao, Jinchang Ren et al.

Text-image alignment constitutes a foundational challenge in multimedia content understanding, where effective modeling of cross-modal semantic correspondences critically enhances retrieval system performance through joint embedding space optimization. Given the inherent difference in information entropy between texts and images, conventional approaches often show an imbalance in the mutual retrieval of these two modalities. To address this particular challenge, we propose to use the open semantic knowledge of Large Language Model (LLM) to fill for the entropy gap and reproduce the alignment ability of humans in these tasks. Our entropy-enhancing alignment is achieved through a two-step process: 1) a new prompt template that does not rely on explicit knowledge in the task domain is designed to use LLM to enhance the polysemy description of the text modality. By analogy, the information entropy of the text modality relative to the visual modality is increased; 2) A hypergraph adapter is used to construct multilateral connections between the text and image modalities, which can correct the positive and negative matching errors for synonymous semantics in the same fixed embedding space, whilst reducing the noise caused by open semantic entropy by mapping the reduced dimensions back to the original dimensions. Comprehensive evaluations on the Flickr30K and MS-COCO benchmarks validate the superiority of our Open Semantic Hypergraph Adapter (OS-HGAdapter), showcasing 16.8\% (text-to-image) and 40.1\% (image-to-text) cross-modal retrieval gains over existing methods while establishing new state-of-the-art performance in semantic alignment tasks.

Xitong Ling, Yifeng Ping, Jiawen Li et al.

Multiple Instance Learning (MIL) plays a significant role in computational pathology, enabling weakly supervised analysis of Whole Slide Image (WSI) datasets. The field of WSI analysis is confronted with a severe long-tailed distribution problem, which significantly impacts the performance of classifiers. Long-tailed distributions lead to class imbalance, where some classes have sparse samples while others are abundant, making it difficult for classifiers to accurately identify minority class samples. To address this issue, we propose an ensemble learning method based on MIL, which employs expert decoders with shared aggregators and consistency constraints to learn diverse distributions and reduce the impact of class imbalance on classifier performance. Moreover, we introduce a multimodal distillation framework that leverages text encoders pre-trained on pathology-text pairs to distill knowledge and guide the MIL aggregator in capturing stronger semantic features relevant to class information. To ensure flexibility, we use learnable prompts to guide the distillation process of the pre-trained text encoder, avoiding limitations imposed by specific prompts. Our method, MDE-MIL, integrates multiple expert branches focusing on specific data distributions to address long-tailed issues. Consistency control ensures generalization across classes. Multimodal distillation enhances feature extraction. Experiments on Camelyon+-LT and PANDA-LT datasets show it outperforms state-of-the-art methods.

Wenhan Dai, Zhi Zeng, Daowei Dou et al.

The monitoring of Cs-137 in seawater using scintillation detector relies on the spectrum analysis method to extract the Cs-137 concentration. And when in poor statistic situation, the calculation result of the traditional net peak area (NPA) method has a large uncertainty. We present a machine learning based method to better analyze the gamma-ray spectrum with low Cs-137 concentration. We apply multilayer perceptron (MLP) to analyze the 662 keV full energy peak of Cs-137 in the seawater spectrum. And the MLP can be trained with a few measured background spectrums by combining the simulated Cs-137 signal with measured background spectrums. Thus, it can save the time of preparing and measuring the standard samples for generating the training dataset. To validate the MLP-based method, we use Geant4 and background gamma-ray spectrums measured by a seaborne monitoring device to generate an independent test dataset to test the result by our method and the traditional NPA method. We find that the MLP-based method achieves a root mean squared error of 0.159, 2.3 times lower than that of the traditional net peak area method, indicating the MLP-based method improves the precision of Cs-137 concentration calculation